Anakinra use while Breastfeeding

Drugs containing Anakinra: Kineret

Anakinra Levels and Effects while Breastfeeding

Summary of Use during Lactation

Anainra is the pharmaceutical name for recombinant human interleukin-1 receptor antagonist (IL-1Ra). IL-1Ra is a normal component of human milk where it may play a role as an anti-inflammatory agent. No data exist on the excretion of anakinra into breastmilk after exogenous administration. One infant was reportedly breastfed during maternal anakinra therapy with no obvious adverse effects. However, long-term follow-up data on infants breastfed during maternal anakinra use are not available. An alternate drug may be preferred, especially while nursing a newborn or preterm infant.

Drug Levels

Maternal Levels. The concentration of IL-1Ra in colostrum in normal mothers was 672 ng/L, which was higher than the plasma concentration. Mature milk levels were lower than those in colostrum. Samples collected over a period of 2 to 6 months postpartum indicated that mothers continued to excrete IL-1Ra during this time.[1] Mothers with acute mastitis had slightly higher average levels of IL-1Ra than levels after recovery, but the median values were the same. The levels found in these mothers were the same as those of control mothers.[2]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

A woman was receiving anakinra 100 mg daily for adult-onset Still's disease during pregnancy and lactation. Her breastfed (extent not stated) infant gained wight and appeared to have normal psychomotor development during an unspecified follow-up period.[3]

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

References

1. Buescher ES, Malinowska I. Soluble receptors and cytokine antagonists in human milk. Pediatr Res. 1996;40:839-44. PMID: 8947960

2. Buescher ES, Hair PS. Human milk anti-inflammatory component contents during acute mastitis. Cell Immunol. 2001;210:87-95. PMID: 11520075

3. Berger CT, Recher M, Steiner U, Hauser TM. A patient's wish: anakinra in pregnancy. Ann Rheum Dis. 2009;68:1794-5. PMID: 19822718

Anakinra Identification

Substance Name

Anakinra

CAS Registry Number

143090-92-0

Drug Class

  • Antirheumatic Agents\
  • Cytokines

Administrative Information

LactMed Record Number

953

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

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