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Effexor XR (venlafaxine) and Alcohol / Food Interactions

There are 2 alcohol/food/lifestyle interactions with Effexor XR (venlafaxine) which include:

Alcohol (Ethanol) ↔ venlafaxine

Moderate Drug Interaction

Using venlafaxine together with ethanol can increase nervous system side effects such as dizziness, drowsiness, and difficulty concentrating. Some people may also experience impairment in thinking and judgment. You should avoid or limit the use of alcohol while being treated with venlafaxine. Do not use more than the recommended dose of venlafaxine, and avoid activities requiring mental alertness such as driving or operating hazardous machinery until you know how the medication affects you. It is important to tell your doctor about all other medications you use, including vitamins and herbs. Do not stop using any medication without first talking to your doctor.

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High Blood Pressure (Hypertension)

Severe Potential Hazard, High plausibility

venlafaxine - hypertension

The use of venlafaxine is associated with dose-dependent, sustained increases in blood pressure, mostly in the range of 10 to 15 mm Hg for supine diastolic blood pressure. The incidence reported for immediate-release venlafaxine in a premarketing study ranged from 3% for dosages < 100 mg/day to 13% for dosages > 300 mg/day. Therapy with venlafaxine should be administered cautiously in patients with preexisting hypertension. Blood pressure should be monitored regularly, and the dosing reduced or discontinued if necessary.


  1. "Product Information. Effexor (venlafaxine)." Wyeth-Ayerst Laboratories, Philadelphia, PA.
  2. Cunningham LA, Borison RL, Carman JS, Chouinard G, Crowder JE, Diamond BI, Fischer DE, Hearst E "A comparison of venlafaxine, trazodone, and placebo in major depression." J Clin Psychopharmacol 14 (1994): 99-106
  3. Settle EC "Antidepressant drugs: disturbing and potentially dangerous adverse effects." J Clin Psychiatry 59 Suppl 16 (1998): 25-30

You should also know about...

Effexor XR (venlafaxine) drug Interactions

There are 1046 drug interactions with Effexor XR (venlafaxine)

Effexor XR (venlafaxine) disease Interactions

There are 5 disease interactions with Effexor XR (venlafaxine) which include:

Drug Interaction Classification

The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.

Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.

Do not stop taking any medications without consulting your healthcare provider.

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