Skip to main content

Effexor

Generic name: venlafaxineVEN-la-fax-een ]
Drug class: Serotonin-norepinephrine reuptake inhibitors

Medically reviewed by Melisa Puckey, BPharm. Last updated on Feb 29, 2024.

What is Effexor?

Effexor (venlafaxine) is used in adults to treat major depressive disorder. Effexor XR extended-release (long-acting) capsules are also used to treat generalized anxiety disorder (GAD; excessive worrying that is difficult to control), social anxiety disorder (extreme fear of interacting with others or performing in front of others that interferes with normal life), and panic disorder (sudden, unexpected attacks of extreme fear and worry about these attacks).

Effexor belongs to in a class of medications called selective serotonin and norepinephrine reuptake inhibitors (SNRIs). Venlafaxine works by increasing the amounts of serotonin and norepinephrine, natural substances in the brain that help maintain mental balance.

Warnings

You should not take Effexor if you have uncontrolled narrow-angle glaucoma.

Do not use Effexor within 7 days before or 14 days after you have used an MAO inhibitor, such as isocarboxazid, linezolid, methylene blue injection, phenelzine, or tranylcypromine.

Some young people have thoughts about suicide when first taking an antidepressant. Stay alert to changes in your mood or symptoms. Report any new or worsening symptoms to your doctor, such as: mood or behavioral changes, anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, hyperactive (mentally or physically), more depressed, or have thoughts about suicide or hurting yourself.

Do not stop using Effexor without first talking to your doctor.

Do not give Effexor to anyone younger than 18 years old without the advice of a doctor. Effexor is not FDA approved for use in children.

Before taking this medicine

You should not take Effexor if you are allergic to venlafaxine or desvenlafaxine (Pristiq).

Do not use Effexor if you have used an MAO inhibitor in the past 14 days. A dangerous drug interaction could occur. MAO inhibitors include isocarboxazid, linezolid, methylene blue injection, phenelzine, and tranylcypromine.

Tell your doctor if you also use stimulant medicine, opioid medicine, herbal products, or medicine for depression, mental illness, Parkinson's disease, migraine headaches, serious infections, or prevention of nausea and vomiting. An interaction with venlafaxine could cause a serious condition called serotonin syndrome.

To make sure Effexor is safe for you, tell your doctor if you have ever had:

Some young people may have increased suicidal thoughts when first starting a medicine to treat depression. Stay alert to changes in your mood or symptoms. Your family or caregivers should also watch for sudden changes in your behavior.

Taking Effexor during pregnancy could harm the baby, but stopping the medicine may not be safe for you. Do not start or stop Effexor without asking your doctor.

If you are pregnant, your name may be listed on a pregnancy registry to track the effects of venlafaxine on the baby.

Ask a doctor if it is safe to breastfeed while using Effexor.

How should I take Effexor?

Take Effexor as prescribed by your doctor. Follow all directions on your prescription label and read all medication guides or instruction sheets. Your doctor may occasionally change your dose.

Take with food at the same time each day.

Swallow the extended-release capsule whole and do not crush or chew.

If you cannot swallow a capsule whole, open it and mix the medicine with applesauce. Swallow the mixture right away without chewing.

Tell your doctor if you have any changes in sexual function, such as loss of interest in sex, trouble having an orgasm, or (in men) problems with erections or ejaculation. Some sexual problems can be treated.

Your symptoms may not improve for up to several weeks. Do not stop using Effexor suddenly, or you could have unpleasant symptoms (such as agitation, confusion, tingling or electric shock feelings). Ask your doctor before stopping the medicine.

Your blood pressure will need to be checked often.

Effexor may cause false results on a drug-screening urine test. Tell the laboratory staff that you use Effexor.

Store at room temperature away from moisture and heat.

Dosing Information

Usual Adult Dose for Depression:

Immediate release:
-Initial dose: 37.5 mg orally twice a day OR 25 mg orally 3 times a day
-Maintenance dose: 75 to 150 mg orally per day, given in divided doses
-Maximum dose:
---Moderately depressed outpatients: 225 mg/day
---Severely depressed inpatients: 375 mg/day

Extended release:
-Initial dose: 75 mg orally once a day
-Maintenance dose: 75 to 225 mg orally once a day
-Maximum dose:
---Moderately depressed outpatients: 225 mg/day
---Severely depressed inpatients: 375 mg/day

Comments:
-The daily dosage of immediate-release formulations may be divided into 2 or 3 doses/day.
-Healthcare providers should consider initial extended release doses of 37.5 mg orally once a day for 4 to 7 days (before increasing the dose to 75 mg/day) in patients who may require additional time to adjust to the drug.
-Doses may be increased in daily increments of up to 75 mg orally at intervals of no less than 4 days.
-Patients should be periodically reassessed for the continued need of maintenance treatment and for the appropriate dose of treatment.
-Use of doses exceeding 225 mg/day is limited.

Usual Adult Dose for Generalized Anxiety Disorder:

Extended release:
-Initial dose: 75 mg orally once a day
-Maintenance dose: 75 to 225 mg orally once a day
-Maximum dose: 225 mg/day

Comments:
-Healthcare providers should consider initial extended release doses of 37.5 mg orally once a day for 4 to 7 days (before increasing the dose to 75 mg/day) in patients who may require additional time to adjust to the drug.
-Doses may be increased in daily increments of up to 75 mg orally at intervals of no less than 4 days.

Usual Adult Dose for Social Anxiety Disorder:

Extended release: 75 mg orally once a day

Comment: There is no evidence that doses greater than 75 mg/day confer additional benefit.

Usual Adult Dose for Panic Disorder:

Extended release:
-Initial dose: 37.5 mg orally once a day for 7 days, then 75 mg orally once a day thereafter
-Maintenance dose: 75 to 225 mg orally once a day
-Maximum dose: 225 mg/day

Comment: Doses may be increased in daily increments of 75 mg orally at intervals of no less than 7 days.

What happens if I miss a dose?

Take the medicine as soon as you can, but skip the missed dose if it is almost time for your next dose. Do not take two doses at one time.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid while taking Effexor?

Do not drink alcohol.

Ask your doctor before taking a nonsteroidal anti-inflammatory drug (NSAID) such as aspirin, ibuprofen, naproxen, Advil, Aleve, Motrin, and others. Using an NSAID with Effexor may cause you to bruise or bleed easily.

Avoid driving or hazardous activity until you know how Effexor will affect you. Your reactions could be impaired.

Effexor side effects

Get emergency medical help if you have signs of an allergic reaction to Effexor: hives; difficult breathing; swelling of your face, lips, tongue, or throat.

Tell your doctor right away if you have new or sudden changes in mood or behavior, including new or worse depression or anxiety, panic attacks, trouble sleeping, or if you feel impulsive, irritable, agitated, hostile, aggressive, restless, more active or talkative, or have thoughts about suicide or hurting yourself.

Venlafaxine may cause serious side effects. Call your doctor at once if you have:

Seek medical attention right away if you have symptoms of serotonin syndrome, such as: agitation, hallucinations, fever, sweating, shivering, fast heart rate, muscle stiffness, twitching, loss of coordination, nausea, vomiting, or diarrhea.

Common Effexor side effects include:

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

What other drugs will affect Effexor?

Using Effexor with other drugs that make you drowsy can worsen this effect. Ask your doctor before using opioid medication, a sleeping pill, a muscle relaxer, or medicine for anxiety or seizures.

Tell your doctor about all your current medicines. Many drugs can interact with venlafaxine, especially:

This list is not complete and many other drugs may interact with venlafaxine. This includes prescription and over-the-counter medicines, vitamins, and herbal products. Not all possible drug interactions are listed here.

Ingredients

Active ingredient: venlafaxine.
Inactive ingredients: Effexor XR extended-release capsules; cellulose, ethylcellulose, gelatin, hypromellose, iron oxides, and titanium dioxide.

Manufacturer

Viatris Inc.: Canonsburg, PA 15317

Popular FAQ

Common antidepressants used for orthopedic pain relief may include SSRIs like fluoxetine (Prozac), paroxetine (Paxil), and sertraline (Zoloft), SNRIs such as duloxetine (Cymbalta), or tricyclic antidepressants (TCAs) like amitriptyline (Elavil) or nortriptyline (Pamelor). Continue reading

Venlafaxine withdrawal symptoms typically last up to 3 to 4 weeks, but may persist even longer. You should avoid abruptly stopping venlafaxine treatment unless otherwise directed by your healthcare provider. Gradually reducing the dose over 4 weeks can help to prevent severe withdrawal symptoms in most people. Continue reading

More FAQ

View more FAQ

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Effexor only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.