Generic name: methoxsalen
Dosage form: injection, solution
This dosage information does not include all the information needed to use Uvadex safely and effectively. See full prescribing information for Uvadex.
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Each UVADEX™ treatment involves collection of leukocytes, photoactivation, and reinfusion of photoactivated cells. UVADEX™ (methoxsalen) Sterile Solution is supplied in 10 mL vials containing 200 mcg of methoxsalen (concentration of 20 mcg/mL). The UVAR™ XTS™ or THERAKOS™ CELLEX™ Photopheresis System Operator's Manual should be consulted before using this product.
During treatment with the UVAR™ XTS™ or THERAKOS™ CELLEX™ Photopheresis System, the dosage of UVADEX™ for each treatment will be calculated according to the treatment volume.
- The prescribed amount of UVADEX™ should be injected into the recirculation bag prior to the Photactivation Phase using the formula:
- TREATMENT VOLUME X 0.017 = mL of UVADEX™ for each treatment
- Example: Treatment volume of 240 mL X 0.017 = 4.1 mL of UVADEX™
Frequency/Schedule of Treatment
Normal Treatment Schedule
Treatment is given on two consecutive days every four weeks for a minimum of seven treatment cycles (six months).
Accelerated Treatment Schedule
If the assessment of the patient during the fourth treatment cycle (approximately three months) reveals an increased skin score from the baseline score, the frequency of treatment may be increased to two consecutive treatments every two weeks. If a 25% improvement in the skin score is attained after four consecutive weeks, the regular treatment schedule may resume. Patients who are maintained in the accelerated treatment schedule may receive a maximum of 20 cycles. There is no clinical evidence to show that treatment with UVADEX™ beyond six months or using a different schedule provides additional benefit. In study CTCL 3, 15 of the 17 responses were seen within six months of treatment and only two patients responded to treatment after six months.