Methoxsalen Levels and Effects while Breastfeeding
Summary of Use during Lactation
No information is available on the use of methoxsalen during breastfeeding. Expert opinion indicates that due to the photosensitizing effects of methoxsalen, breastfeeding should be withheld for 24 hours after an oral dose to allow for 95% of the drug to be eliminated in the mother's urine.[1,2] The same precaution probably applies to patients receiving methoxsalen as a part of therapy for cutaneous T-cell lymphoma. Use of topical methoxsalen is not contraindicated during breastfeeding, but avoid direct contact of the treated skin with the skin of the infant.[3,4]
Drug Levels
Maternal Levels. Relevant published information was not found as of the revision date.
Infant Levels. Relevant published information was not found as of the revision date.
Effects in Breastfed Infants
Relevant published information was not found as of the revision date.
Effects on Lactation and Breastmilk
Relevant published information was not found as of the revision date.
Menter A, Korman NJ, Elmets CA, et al. Guidelines of care for the management of psoriasis and psoriatic arthritis: Section 5. Guidelines of care for the treatment of psoriasis with phototherapy and photochemotherapy. J Am Acad Dermatol 2010;62:114-35. [PubMed: 19811850]
2.
Butler DC, Heller MM, Murase JE. Safety of dermatologic medications in pregnancy and lactation: Part II. Lactation. J Am Acad Dermatol 2014;70:417.e1-10. [PubMed: 24528912]
3.
Reed BR. Dermatologic drug use during pregnancy and lactation. Dermatol Clin 1997;15:197-206. [PubMed: 9001872]
4.
Reed BR. Dermatologic drugs, pregnancy, and lactation. A conservative guide. Arch Dermatol 1997;133:894-8. [PubMed: 9236528]
Substance Identification
Substance Name
Methoxsalen
CAS Registry Number
298-81-7
Drug Class
Breast Feeding
Lactation
Milk, Human
Dermatologic Agents
Photosensitizing Agents
Coumarins
Furocoumarins
Psoralens
PUVA Therapy
Disclaimer: Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.
