Terbinafine Dosage

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Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Onychomycosis - Fingernail

Tablets: 250 mg orally once a day for 6 weeks

Comments:
-Optimal clinical effect observed some months after mycological cure and end of therapy; related to time required for outgrowth of healthy nail.

Approved indication: Treatment of onychomycosis of the fingernail due to dermatophytes (tinea unguium)

Usual Adult Dose for Onychomycosis - Toenail

Tablets: 250 mg orally once a day for 12 weeks

Comments:
-Optimal clinical effect observed some months after mycological cure and end of therapy; related to time required for outgrowth of healthy nail.

Approved indication: Treatment of onychomycosis of the toenail due to dermatophytes (tinea unguium)

Usual Adult Dose for Tinea Capitis

Oral granules: 250 mg orally once a day for 6 weeks

Comments:
-Some evidence suggests that a longer duration of therapy (e.g., 6 to 8 weeks) or higher dosage may be necessary when tinea capitis is caused by Microsporum canis.

Usual Adult Dose for Cutaneous Candidiasis

(Not approved by FDA)

Tablets: 250 mg orally once a day for 2 to 4 weeks

Usual Adult Dose for Tinea Corporis

(Not approved by FDA)

Tablets: 250 mg orally once a day for 2 to 4 weeks

Usual Adult Dose for Tinea Cruris

(Not approved by FDA)

Tablets: 250 mg orally once a day for 2 to 4 weeks

Usual Adult Dose for Tinea Pedis

(Not approved by FDA)

Tablets: 250 mg orally once a day for 2 to 6 weeks

Usual Pediatric Dose for Tinea Capitis

Oral granules:
4 years or older:
Less than 25 kg: 125 mg orally once a day
25 to 35 kg: 187.5 mg orally once a day
Greater than 35 kg: 250 mg orally once a day

Duration of therapy: 6 weeks

Comments:
-Some evidence suggests that a longer duration of therapy (e.g., 6 to 8 weeks) or higher dosage may be necessary when tinea capitis is caused by Microsporum canis.

Renal Dose Adjustments

CrCl 50 mL/min or less: Data not available

Liver Dose Adjustments

Chronic or active liver disease: Not recommended.

Precautions

Consult WARNINGS section for dosing related precautions.

Dialysis

Data not available

Other Comments

Administration advice:
-Oral granules: Take with food. Sprinkle the contents of each packet on a spoonful of pudding or other soft, nonacidic food (e.g., mashed potatoes) and swallow the entire spoonful without chewing; do not use applesauce or fruit-based foods.

General:
-Before starting therapy with terbinafine tablets, appropriate nail specimens for laboratory testing (potassium hydroxide preparation, fungal culture, or nail biopsy) should be obtained to confirm the diagnosis of onychomycosis.
-Clinical resolution may not be observed until several weeks after mycological cure.

Monitoring:
-Hematologic: Complete blood counts in patients with immunodeficiency (known or suspected) using terbinafine for more than 6 weeks or if clinical signs/symptoms suggestive of secondary infection develop
-Hepatic: Serum transaminases (ALT and AST) in all patients before starting therapy
-Psychiatric: Depressive symptoms

Patient advice:
-Minimize exposure to natural and artificial sunlight (tanning beds or UVA/B treatment) during therapy.

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