Caffeine Dosage

This dosage information may not include all the information needed to use Caffeine safely and effectively. See additional information for Caffeine.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Drowsiness

100 to 200 mg orally not more often than every 3 to 4 hours.

For occasional use only.

Not intended for use as a substitute for sleep.

Limit the use of caffeine containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and occasionally, rapid heartbeat.

Usual Pediatric Dose for Drowsiness

>= 12 years: 100 to 200 mg not more often than every 3 to 4 hours.

For occasional use only.

Not intended for use as a substitute for sleep.

Limit the use of caffeine containing medications, foods, or beverages while taking this product because too much caffeine may cause nervousness, irritability, sleeplessness, and occasionally, rapid heartbeat.

Usual Pediatric Dose for Apnea of Prematurity

For short term treatment of apnea of prematurity in infants between 28 and <33 weeks gestational age.

Prior to initiation of caffeine citrate, baseline serum levels of caffeine should be measured in infants previously treated with theophylline, since preterm infants metabolize theophylline to caffeine. Likewise, baseline serum levels of caffeine should be measured in infants born to mothers who consumed caffeine prior to delivery, since caffeine readily crosses the placenta.

Loading Dose: 20 mg/kg caffeine citrate intravenous (over 30 minutes) once

Maintenance Dose: 5 mg/kg caffeine citrate intravenous (over 10 minutes) or orally every 24 hours.

Note: The dose of caffeine base is one-half the dose when expressed as caffeine citrate (e.g., 20 mg of caffeine citrate is equivalent to 10 mg of caffeine base).

Serum concentrations of caffeine may need to be monitored periodically throughout treatment to avoid toxicity. Serious toxicity has been associated with serum levels greater than 50 mg/L.

Apnea of prematurity is a diagnosis of exclusion. Other causes of apnea (e.g., central nervous system disorders, primary lung disease, anemia, sepsis, metabolic disturbances, cardiovascular abnormalities, or obstructive apnea) should be ruled out or properly treated prior to initiation of caffeine citrate.

Caffeine citrate should be used with caution in infants with seizure disorders or cardiovascular disease.

The duration of treatment of apnea of prematurity in the placebo-controlled trial was limited to 10 to 12 days. The safety and efficacy of caffeine citrate for longer periods of treatment have not been established.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Caffeine citrate should be administered with caution in infants with impaired renal or hepatic function.

Caffeine is a central nervous system stimulant and in cases of caffeine overdose, seizures have been reported.

Dialysis

Data not available

Other Comments

If a timed released oral caffeine preparation is used, the dose should not be taken less than 6 hours before bedtime.

One study has reported that while favorable subjective and performance- enhancing stimulant effects occur at low to intermediate caffeine doses, the unfavorable subjective and somatic effects, as well as performance disruption from high doses of caffeine may intrinsically limit the doses of caffeine used in the general population.

In preterm neonates receiving recommended standard doses of caffeine for apnea, the majority of neonates achieve plasma concentrations of 5 to 20 mg/L. Routine monitoring of plasma caffeine levels during treatment of apnea of prematurity does not appear to be necessary.

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