Lioresal (baclofen) Disease Interactions
There are 4 disease interactions with Lioresal (baclofen):
Baclofen (Includes Lioresal) ↔ Renal Dysfunction
Severe Potential Hazard, High plausibility
Applies to: Renal Dysfunction
Baclofen is primarily eliminated by the kidney. Patients with impaired renal function may be at greater risk for adverse effects from baclofen due to decreased drug clearance. Therapy with baclofen should be administered cautiously in such patients. Dosage adjustments may be necessary.
Baclofen (Includes Lioresal) ↔ Autonomic Dysreflexia
Moderate Potential Hazard, Moderate plausibility
Applies to: Autonomic Dysreflexia
Therapy with intrathecal baclofen should be administered cautiously in patients with a history of autonomic dysreflexia, since the presence of nociceptive stimuli or abrupt withdrawal of the medication may trigger an episode of dysreflexia.
Baclofen (Includes Lioresal) ↔ Psychoses
Moderate Potential Hazard, Moderate plausibility
Applies to: Psychosis, History - Psychiatric Disorder
Baclofen may precipitate or exacerbate psychotic symptoms, both during therapy and following abrupt withdrawal of the drug. Therapy with baclofen should be administered cautiously in patients with a history of psychiatric disorders.
Baclofen (Includes Lioresal) ↔ Seizure Disorders
Moderate Potential Hazard, Moderate plausibility
Applies to: Seizures
Deterioration in seizure control and electroencephalographic (EEG) changes have been reported occasionally in epileptic patients treated with baclofen. Therapy with baclofen should be administered cautiously in patients with a history of seizures. Clinical status and EEG should be monitored at regular intervals during treatment. Except in cases of overdose or severe adverse reactions, cessation of baclofen therapy, whenever necessary, should occur gradually with incrementally reduced dosages. Abrupt withdrawal has been associated with central nervous system effects including seizures, hallucinations, and psychosis.
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Lioresal (baclofen) drug Interactions
There are 651 drug interactions with Lioresal (baclofen)
Lioresal (baclofen) alcohol/food Interactions
There is 1 alcohol/food interaction with Lioresal (baclofen)
See also...
Drug Interaction Classification
The classifications below are a general guideline only. It is difficult to determine the relevance of a particular drug interaction to any individual given the large number of variables.
| Major | Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit. |
| Moderate | Moderately clinically significant. Usually avoid combinations; use it only under special circumstances. |
| Minor | Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan. |
Do not stop taking any medications without consulting your healthcare provider.
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