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Lioresal Intrathecal Disease Interactions

There are 4 disease interactions with Lioresal Intrathecal (baclofen).

Major

Baclofen (applies to Lioresal Intrathecal) renal dysfunction

Major Potential Hazard, High plausibility.

Baclofen is primarily eliminated by the kidney. Patients with impaired renal function may be at greater risk for adverse effects from baclofen due to decreased drug clearance. Therapy with baclofen should be administered cautiously in such patients. Dosage adjustments may be necessary.

References

  1. Himmelsbach FA, Kohler E, Zanker B (1992) "Toxic effect of baclofen in chronic haemodialysis and renal transplantation." Dtsch Med Wochenschr, 117, p. 733-7
  2. Krahn A, Penner SB (1994) "Use of baclofen for intractable hiccups in uremia." Am J Med, 96, p. 391
  3. (2001) "Product Information. Lioresal (baclofen)." Medtronic Neurological
Moderate

Baclofen (applies to Lioresal Intrathecal) autonomic dysreflexia

Moderate Potential Hazard, Moderate plausibility.

Therapy with intrathecal baclofen should be administered cautiously in patients with a history of autonomic dysreflexia, since the presence of nociceptive stimuli or abrupt withdrawal of the medication may trigger an episode of dysreflexia.

References

  1. (2001) "Product Information. Lioresal Intrathecal (baclofen)." Medtronic Neurological
Moderate

Baclofen (applies to Lioresal Intrathecal) psychoses

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Psychosis, History - Psychiatric Disorder

Baclofen may precipitate or exacerbate psychotic symptoms, both during therapy and following abrupt withdrawal of the drug. Therapy with baclofen should be administered cautiously in patients with a history of psychiatric disorders.

References

  1. Kirubakaran V, Mayfield D, Rengachary S (1984) "Dyskinesia and psychosis in a patient following baclofen withdrawal." Am J Psychiatry, 141, p. 692-3
  2. Arnold ES, Rudd SM, Kirshner H (1980) "Manic psychosis following rapid withdrawal from baclofen." Am J Psychiatry, 137, p. 1466-7
  3. Siegfried RN, Jacobson L, Chabal C (1992) "Development of an acute withdrawal syndrome following the cessation of intrathecal baclofen in a patient with spasticity." Anesthesiology, 77, p. 1048-50
  4. Terrence CF, Fromm GH (1981) "Complications of baclofen withdrawal." Arch Neurol, 38, p. 588-9
  5. Sommer BR, Petrides G (1992) "A case of baclofen-induced psychotic depression." J Clin Psychiatry, 53, p. 211-2
  6. Yassa RY, Iskandar HL (1988) "Baclofen-induced psychosis: two cases and a review." J Clin Psychiatry, 49, p. 318-20
  7. Penn RD (1992) "Intrathecal baclofen for spasticity of spinal origin: seven years of experience." J Neurosurg, 77, p. 236-40
  8. Rivas DA, Chancellor MB, Hill K, Freedman MK (1993) "Neurological manifestations of baclofen withdrawal." J Urol, 150, p. 1903-5
  9. Lees AJ, Clarke CR, Harrison MJ (1977) "Hallucinations after sudden withdrawal of baclofen." Lancet, 2, p. 44-5
  10. Wolf ME, Almy G, Toll M, Mosnaim AD (1982) "Mania associated with the use of baclofen." Biol Psychiatry, 17, p. 757-9
  11. Sandyk R, Gillman MA (1985) "Baclofen-induced memory impairment." Clin Neuropharmacol, 8, p. 294-5
  12. Garabedian-Ruffalo SM, Ruffalo RL (1985) "Adverse effects secondary to baclofen withdrawal." Drug Intell Clin Pharm, 19, p. 304-6
  13. Stewart JT (1992) "A case of mania associated with high-dose baclofen therapy." J Clin Psychopharmacol, 12, p. 215-7
  14. Jamous A, Kennedy P, Psychol C, Grey N (1994) "Psychological and emotional effects of the use of oral baclofen - a preliminary study." Paraplegia, 32, p. 349-53
  15. (2001) "Product Information. Lioresal (baclofen)." Medtronic Neurological
View all 15 references
Moderate

Baclofen (applies to Lioresal Intrathecal) seizure disorders

Moderate Potential Hazard, Moderate plausibility. Applicable conditions: Seizures

Deterioration in seizure control and electroencephalographic (EEG) changes have been reported occasionally in epileptic patients treated with baclofen. Therapy with baclofen should be administered cautiously in patients with a history of seizures. Clinical status and EEG should be monitored at regular intervals during treatment. Except in cases of overdose or severe adverse reactions, cessation of baclofen therapy, whenever necessary, should occur gradually with incrementally reduced dosages. Abrupt withdrawal has been associated with central nervous system effects including seizures, hallucinations, and psychosis.

References

  1. Kirubakaran V, Mayfield D, Rengachary S (1984) "Dyskinesia and psychosis in a patient following baclofen withdrawal." Am J Psychiatry, 141, p. 692-3
  2. Arnold ES, Rudd SM, Kirshner H (1980) "Manic psychosis following rapid withdrawal from baclofen." Am J Psychiatry, 137, p. 1466-7
  3. Siegfried RN, Jacobson L, Chabal C (1992) "Development of an acute withdrawal syndrome following the cessation of intrathecal baclofen in a patient with spasticity." Anesthesiology, 77, p. 1048-50
  4. Abarbanel J, Herishanu Y, Frisher S (1985) "Encephalopathy associated with baclofen." Ann Neurol, 17, p. 617-8
  5. Terrence CF, Fromm GH (1981) "Complications of baclofen withdrawal." Arch Neurol, 38, p. 588-9
  6. Hormes JT, Benarroch EE, Rodriguez M, Klass DW (1988) "Periodic sharp waves in baclofen-induced encephalopathy." Arch Neurol, 45, p. 814-5
  7. Penn RD (1992) "Intrathecal baclofen for spasticity of spinal origin: seven years of experience." J Neurosurg, 77, p. 236-40
  8. Rush JM, Gibberd FB (1990) "Baclofen-induced epilepsy." J R Soc Med, 83, p. 115-6
  9. Rivas DA, Chancellor MB, Hill K, Freedman MK (1993) "Neurological manifestations of baclofen withdrawal." J Urol, 150, p. 1903-5
  10. Barker I, Grant IS (1982) "Convulsions after abrupt withdrawal of baclofen." Lancet, 2, p. 556-7
  11. Lees AJ, Clarke CR, Harrison MJ (1977) "Hallucinations after sudden withdrawal of baclofen." Lancet, 2, p. 44-5
  12. Kofler M, Arturo Leis A (1992) "Prolonged seizure activity after baclofen withdrawal." Neurology, 42, p. 697-8
  13. Garabedian-Ruffalo SM, Ruffalo RL (1985) "Adverse effects secondary to baclofen withdrawal." Drug Intell Clin Pharm, 19, p. 304-6
  14. (2001) "Product Information. Lioresal (baclofen)." Medtronic Neurological
  15. Zak R, Solomon G, Petito F, Labar D (1994) "Baclofen-induced generalized nonconvulsive status epilepticus." Ann Neurol, 36, p. 113-4
View all 15 references

Lioresal Intrathecal drug interactions

There are 365 drug interactions with Lioresal Intrathecal (baclofen).

Lioresal Intrathecal alcohol/food interactions

There is 1 alcohol/food interaction with Lioresal Intrathecal (baclofen).

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Drug Interaction Classification

These classifications are only a guideline. The relevance of a particular drug interaction to a specific individual is difficult to determine. Always consult your healthcare provider before starting or stopping any medication.
Major Highly clinically significant. Avoid combinations; the risk of the interaction outweighs the benefit.
Moderate Moderately clinically significant. Usually avoid combinations; use it only under special circumstances.
Minor Minimally clinically significant. Minimize risk; assess risk and consider an alternative drug, take steps to circumvent the interaction risk and/or institute a monitoring plan.
Unknown No interaction information available.

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