User Reviews for Modafinil
Also known as: Provigil
The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
Learn more about Modafinil.
Reviews for Modafinil to treat Depression
"I have been working for many years with one combination after another of medications for bi polar disorder. I was recently on oxcarbazapine and lithium which was great for a few months. Depression came back and I had unpleasant side effects with the oxcarbazapine. My doc added modafanil. It reduced the side effects and improved my depression. It also caused irritability. And caffeine made me restless even with a small amount."
upndwn June 27, 2015
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"Since diagnosis I have been on almost every medication that has been introduced. For the last five years I have taken 300mg Bupropion, 300mg Gabapentin 3/day, 200mg Modafinil, and additionally, Xanax, as needed. The Bupropion alone was not helping somatic symptoms and the Gabapentin solved that. The added Modafinil caused no noticeable side effects. It did provide increased energy, a more positive mood, emotional stability, and a feeling of cheerfulness which was foreign to me. It does not prevent a good afternoon nap when needed and has never interfered with sleep at night. As I told my physician, "The bupropion keeps me from wanting to die and the modafinil makes me want to live," Any minor side effects would be worth the benefits"
Depression diagnosed in 1965 (taken for 5 to 10 years) June 24, 2015
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"It was a strong drug. It had the side effect of leaving me tired and very depleted the following day far more than small 5mg of ritalin did. The only caveat is I took valium at bedtime. This may have messed with the Provigil to the degree that it may have messed with my system. I think this entry is valuable. Benzodiazepines do not appear to be useful in combination with Provigil or Modafinil. Days when I did not take Benzodiazepines the following days were pretty normal. The important entry I want to contribute is to say that the days following a Provigil day were the ones that were the most productive. I was far more "on" after the drug wore off. I felt like a younger faster version of myself days even a week later. 100mg dose"
BillZimm (taken for less than 1 month) April 23, 2015
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"I have suffered from major depression for over 20 years. The past 2 1/2 years have been devastating. I have now treatment resistant depression. I have been on all of the "modern" and some "old school" antidepressants including Lithium and MAOIs. I have had 2 rounds of ECT treatments in the past 2 years. They have knocked the suicidal ideation for a little while but this most recent round of 12 required "Maintenance" sessions. I have had 3 maintenance ECTs then my psych doc prescribed me Provigil. I started at 100 mg for 2 weeks then upped it to 200 mg. for the past 2 weeks. I have made it through the holiday season feeling the best I have in years. Now I am back to the way I was before my depression. Don't know why but it works."
downindumps (taken for less than 1 month) December 28, 2014
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"After many hospital stays for trying all the different medications for bi-polar depression Modafinil has been part of my regimen with gabapentin and nortriptyline. Any regular medication for bi-polar disorder has side effects such as deja vu to diarrhea. My wife changed jobs but took the new one on the basis that it was the same insurance carrier and would continue coverage. Now because they say Modafinil is not a bi-polar medicine they refuse to pay for it. I will not be able to afford the $650 a month. Without it I wake with nightmares. It's very sad insurance says they know better than a group of doctors and 10 years of success using a prescription."
Progenitor (taken for 10 years or more) December 16, 2014
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"I was diagnosed with Bipolar disorder back in 2002 and I've tried every medication under the sun with no success. Then in 2006 my doctor tried me on Modafinil as add on to my other medications, I was really surprised at the effectiveness of modafinil. On my depressed cycle it made me get off the sofa and lessened my depression. During my mania cycle I would not have to take Modafinil. It is definitely a medication worth trying as an add to as add on."
casreid1962 (taken for 10 years or more) December 11, 2014
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"I take a 1/4 of a pill Modafinil together with 1/4 paroxetine 5mg in the morning, never felt better. I have tried other options like Wellbutrin, RITALIN but with erratic results, you should try modafinil and you would be surprised."
omchanti (taken for 1 to 2 years) July 27, 2014
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"I selected depression but at this point I believe depression is a side effect to a larger Neurological issue and apnea. I was diagnosed with Depression years ago and after being put on tonnes of different medicines some of which were a nightmare I was upgraded to Bi-Polar. Along the way I gained about 100lbs and eventually ended up on a cocktail that included Seroquel which made me very sleepy all the time. I was initially given Provigil as a way to be awake during the day. It was a very positive improvement. After a while I was adjusted to Seroquel, Lamictal and Provigil, and it seemed to keep me stable but still lethargic. Eventually we tried lessening the Seroquel and eventually eliminated it. I am doing better than ever now for several years."
D.M.N. (taken for 5 to 10 years) June 5, 2014
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"My depression is responsible for a sleeping disorder that makes it very hard for me to stay awake and functional: I have some kind of hypersomnia instead of the regular insomnia complaints patients have. Even though there are people that respond nicely to modafinil, I didn't feel anything while associating 200mg of it to my SSRI. I couldn't notice any improvement to my sleeping cycle or to my concentration. Side effects were absent too. Unfortunately it was not for me."
Fernanda P (taken for 1 to 6 months) October 31, 2013
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"Had this added to my anti-depressant cocktail and I have to admit, it's given me more energy and increased my mood quite a bit. I was really surprised at it's effectiveness for depression and depression related fatigue. The only drawback for me is that I often get headaches when it starts to wear off. But overall a good medicine!"
Suze1227 September 11, 2013
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"I selected "depression" but this medicine has been beneficial for fatigue and hypersomnia as well. Started using this medicine in 2006! Yes, and I have tried almost everything else for depression, and I cannot say the side-effects or results from so-called approved depression medications were ever worth the horror they delivered. So, yes, I would recommend this for depression in the form of modafinil."
Modalert User February 19, 2013
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"Provigil was added to my meds for depression. I love it! Modafinil has made more of a difference than anything I've ever been given. I can concentrate now and actually have more get up and go than I've had in years. I take 100 mg everyday. Tried 200 mg, but feel just fine with 100 mg."
hellogal (taken for 6 months to 1 year) December 14, 2012
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"I read the experiences of people on Provigil before I tried it and as I was in the midst of a very deep depression and has tried so many other anti-depressants. I was suicidal and desperate for help. As most other people found, it is a miracle! I cannot believe that I feel this good. I am back to my old positive self. I am taking 200 mgm in the morning. The last medicine that worked was Adderall which worked initially but wore off after a year. I still had the rapid heart beat, but the depression continued. Thank you to everyone who posted their positive feedback as it gave me hope that the medicine might work. This is an off label use, but it sure works for me!"
sgc46 March 9, 2012
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Provigil (modafinil): "I was initially prescribed this medication to address both a mild sleep apnea problem and persistent depression. Initially, it was indeed like a miracle drug. I felt better immediately and continued so for about a year. However, the drug then quickly became less effective and actually began to make my depression much worse. I very briefly switched to Nuvigil, but I continued with the worsening depression and ended up having to stop the medication. Within a few days of discontinuing the medication, I felt considerably better. I went on to other medications to help with the depression and fatigue. Provigil/Nuvigil has been a blessing for many people. However, as with many medications, their continued use can sometimes backfire."
Anonymous March 3, 2010
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Provigil (modafinil): "Provigil has been a HUGE help for me. I take nortriptyline for my depression. It works better than anything else I've tried but it makes it impossible for me to get up in the morning. When my alarm goes off at 7am I feel like I'm being tortured. I take half a tablet of Provigil at bedtime (11pm). It doesn't keep me from falling asleep but it does help me wake up alert at 7am. Without it, I'll sleep until at least 11:30am. This may be an off-label use but it makes it possible for me to take my antidepressant AND get to school/work on time."
Anonymous January 6, 2010
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Provigil (modafinil): "This turned me from a deep, suicidal depression into a happy, productive person in 2 days. I am also able to sleep without any sleep medicines (first time in years). My problem is that my insurance refuses to pay for it because using Provigil for depression/bipolar is off-label, and it is so expensive that I'm just starting to wean myself off of it, sadly. There is another drug, Nuvigil that is supposed to be even better, and is currently being tested (very positive results so far) for FDA approval in the use of it for depression and bipolar. It's been a long road for me, so I can only pray that the FDA moves quickly on this."
Anonymous June 4, 2009
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Provigil (modafinil): "This is a WONDER DRUG in the use of depression. I have suffered for years with depression and never with any relief from the mainstream anti-depressants. Either the side effects were intolerable, or the medicine just didn't work. Within 3 days of taking Provigil, I was the happiest, most productive I had been in a year. The first 2 days I was still really sleepy, and the 3rd day, a little hyper, but after that day I have felt EXCELLENT. I don't have anxiety attacks anymore and I get a full night of "good" sleep and wake up feeling extremely refreshed and I am happy again. I was on my couch for a straight 6 months sleeping and crying until I started this medicine. It literally saved my life."
jaguiar May 20, 2009
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"I use several antidepressants, and I cannot function without them. Modafinil helped with my chronic fatigue, but it's not an antidepressant in my opinion. I can do a lot of things now. I'm so glad I heard about it. I take 200mg a day."
Anonymous May 17, 2009
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Learn more about Depression
Micromedex® Care Notes:
- Depression After Spinal Cord Injury
- Depression In Children, Ambulatory Care
- Depression, Ambulatory Care
Related encyclopedia articles:
- Adjustment disorder
- Aging changes in sleep
- Chemical dependence - resources
- Depression - older adults
- Depression - overview
- Depression - resources
- Loss of a spouse - resources
- Major depression
- Seasonal affective disorder
- Stress management
Drugs.com Health Center:
More about modafinil
- Other brands: Provigil