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Pristiq for Depression User Reviews (Page 3)

Pristiq has an average rating of 6.9 out of 10 from a total of 743 reviews for the treatment of Depression. 59% of reviewers reported a positive experience, while 22% reported a negative experience.

Reviews for Pristiq

  • Anonymous
  • August 28, 2008

"I have been on Pristiq for about 2 months. I've tried probably 10-12 other anti-depressents with lots of side effects that made me want to quit them. I feel better emotionally today. I have no side effects and I am able to complete tasks in a reasonable amount of time, without feeling overwhelmed. I have no anxiety issues and I am finally enjoying my life. I only wish the insurance industry would cover this medication."

10 / 10
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198 Report
  • Ga girl
  • Taken for less than 1 month
  • May 27, 2014

"Been off/on antidepressants for 20 years. Been on 100 mg of Zoloft for about 5 years now and was having some adverse effects- gained a lot of weight for starters. Started Pristiq about 3 weeks ago. I feel a lot clearer in the mind- guess I didn't realize the Fog I was in on the Zoloft. I'm not hungry- lost seven pounds in the first two weeks. Had some headaches while switching over. Sleep hasn't been a problem- but I have found that I need to take the meds at the same time in the mornings or I have headaches. So far, so good. Hopefully it will continue long term. I will probably be on meds the rest of my life- I've come to terms with that. Hoping this will be the last one I'm on!"

9 / 10
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140 Report
  • Anonj
  • April 11, 2016

"Absolutely no side effects. I lost weight on this medication, however if you do not want to lose weight, talk to your psychiatrist and they can prescribe medications that can help you gain weight if you are underweight. This medication worked perfectly on my depression and I have not relapsed since I was weaned off it. No sexual side effects, it actually helped my sex life I am so happy I tried it."

10 / 10
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115 Report

Frequently asked questions

  • Amand...
  • December 3, 2014

"Finally I see hope. After being diagnosed with severe depression (took me 4 years to seek treatment), I tried 5 different medications (plus therapy). They all failed miserably and I lost the hope I didn't even know I had, then tried suicide twice. Finally I was prescribed Pristiq and let me just say... what a difference! It got easier to wake up and get through the day, my self-esteem got better, my anxiety doesn't come as often, and I can even make plans for the future. For the first time I see change is possible. Just don't ever forget to take your pills, you can't really function without them. I got no side effects except for increased hunger/libido, and a bit of difficulty falling asleep. I'm taking 150mg now."

8 / 10
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129 Report
  • MAB
  • Taken for 1 to 6 months
  • February 17, 2020

"Initially Pristiq kept me on an even keel. Then it didn’t seem to make a difference. I don’t feel interested in anything. I have gained 20 lbs in six months. I told my doctor and she said to stop taking it. Easier said than done. It made me extremely sick. Headache and nervousness were unbearable"

3 / 10
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70 Report

Are you taking this medicine?

  • Kevin
  • January 23, 2014

"Went to the doctor complaining of anxiety. Was waking up and not falling back asleep or even worse could not fall asleep. Was also having anxiety attacks. The last time this happened I was prescribed effexor which was a nightmare and Celexa which did nothing for me. Ended up quitting my job and with time off I returned to normal. Quitting my job this time is not a option so the doctor put me on Pristiq. Noticed a positive effect within 7 days and I have been on it for a month now. This drug has worked absolute wonders for me. I have had no side effects at all (and no sexual impotency)."

10 / 10
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136 Report
  • Jo Girl
  • November 22, 2013

"Have been taking Pristiq for just on a month -- relief from anxiety and depression after 3 days and able to concentrate and focus again to full capacity -- no side effects and sleeping well. I was on Efexor on and off for 10 years, with not a lot of relief from anxiety symptoms. Have lost some weight as well, and am starting to feel very positive."

9 / 10
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137 Report
  • Pristiq...
  • March 21, 2009

"I've been on Pristiq for 8 weeks and believe me, I have never felt better in my life. It works, no side effects. I'm a happy person now. The only thing I wouldn't do is to take Pristiq at night time. I take it at 8:00am, so I don't have sleeping problems. Try it this way. This medicine is wonderful. GOOD LUCK EVERYBODY."

10 / 10
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180 Report
  • Johnny
  • Taken for 1 to 6 months
  • August 4, 2018

"Depression is like being dead while you're alive. It the most scary illness in the world. After doing a genetic test while on effexor (that made my depression worst) pristiq was the best result. I have no side effects, life is good again. Don't loose hope. This medication works, the side effects is due to interaction in the body chemistry, while you do a genetic test you'll find a drug that will balance your brain. I wish you all the best"

9 / 10
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87 Report
  • WCano
  • Taken for 1 to 6 months
  • February 25, 2013

"Best medication EVER! After 2 years of feeling angry and upset and constantly fighting with my husband (over stupid things) and having suicidal and self harm thoughts purely from severe depression, I am now feeling 100% absolutely fantastic ALL the time thanks to Pristiq! Before I could barely get out of bed now I have heaps of energy to last all day and am constantly on the go. I LOVE how this medication makes me feel. I'd highly recommend trying this antidepressant."

10 / 10
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143 Report
  • beebl...
  • April 14, 2015

"hello, I am a 24 year old male who has been dealing with depression, anxiety, and lack of focus in my life four a couple years now. After a recommendation from a friend i decided to make a change and start on 50mg of prestiq. Im a relatively small person 5'5 130 pounds and immediately felt the effects of the medication. I had a huge surge of energy that was a little overwhelming. I was much more sociable and confident, also my curiosity was dramatically increased and i managed to blaze through several books in a weeks time. This was a huge shift in my normal behavior which was generally lazy and unfocused. Now I've been on the drug for about 3 months and the effects aren't as noticeable but I'd say my life has changed for the better."

10 / 10
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122 Report
  • Coope...
  • June 7, 2015

"My Doctor put me one 100 mgs once in the morning and I could tell a huge difference in the way I felt, for the first time I felt like I could breathe, I could see colors again, the tree's, the flower's everything changed from grey to vivid brightness, however this effect was not immediate. I was taking 120 mg's of Cymbalta, 2 60 mg caps. a day, when this was the medicine I was one for years, I fought a good fight with doctor's over years and years. They were telling me I was Bi-Polor and I believed them. It took one great doctor 15 minutes to change my life. I have been on Pristiq 100 mg's for going on 3 years know and I love life again, I can't wait to wake up early in the morning and watch the sunrise and I found out that I wasn't bipolor"

10 / 10
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119 Report
  • ccsk
  • Taken for 1 to 2 years
  • December 9, 2014

"I have had depression for a long time, sometimes more serious, sometimes less serious. In the past 7 years, I think I experience a "re-entry shock" going back to the teaching profession in HK. I need to take it once per day. I did not experience any side effect like sleepiness, dizziness. I can perform my normally heavy duties in my workplace. At first my doctor ask me to take it after evening, but since it will not affect my work and need not be taken after meals, I prefer to take it right after I get up, and I can establish a routine for it easily. Soon after I have taken Pristig, all my negative thoughts and feelings disappear like miracle and many people around me commented that I am happier than before."

10 / 10
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121 Report
  • MKate
  • Taken for 1 to 6 months
  • February 8, 2020

"Pristiq has been a life changer for me. I know it gets a lot of bad reviews on here, because I looked at them before I started it lol. But it may be the med that works for you. I have not felt this good in years. My energy is good, I laugh way more now, I am able to recognize and replace old negative thoughts with more positive ones. I have gained a few lbs but it’s nothing compared to living in depression. I am so thankful for this medication after trying 3 other meds that weren’t very helpful. I hope the good effects continue. Only side effects are sweating and sometimes I’ll wake up in the night and be unable to fall back asleep for an hour or two."

9 / 10
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66 Report
  • trixi...
  • December 18, 2014

"I have been on Pristiq for about 3 months. I had insane anxiety and depression as well as insomnia that got so bad I ended up in the ER. I don't care if I ever come off of Pristiq because it works. I am normal again. I sleep, and for about 2 months I almost forgot what it was like to feel so anxious I could hardly function at work or life. I hesitated to start this medicine because my psychiatrist told me absolutely no drinking. I do have a few drinks on weekends and have no side effects from it. "

10 / 10
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119 Report
  • NYC...
  • Taken for 2 to 5 years
  • June 26, 2013

"My experience with Pristiq 50 mg works wonderfully. I've been on it for more than 2 years and don't prefer any other. It's low on side effects and it makes me feel like my true natural self, no zombie feeling at all. For the women in their 40's...Pristiq is a miracle medicine to lessen hot flashes and allows you to sleep well. No worry with sex problems, you will not have any problem."

10 / 10
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132 Report
  • Tim
  • February 28, 2014

"I had been on Pristiq for about 1 year at 50mg. While on it, the feelings of depression and anxiety pretty much disappeared. However, after changing my lifestyle for the better and going off Pristiq I have been dealing with withdrawal side effects. It has been 4 weeks now and I still have the brain zaps which make me feel unsteady. These zaps have been continuous and extremely upsetting. Add to this the deep states of sadness (mention the least sad thing and I would start crying) and the nightmares....it has been a very rough 4 weeks. For the last week I have had blood pressure swings from 110/60 to 218/111 and weakness in the large muscles of my legs and arms. For those going on or off, be careful!"

5 / 10
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125 Report
  • ERNYC
  • Taken for 1 to 2 years
  • April 29, 2015

"Pristiq has been a miracle for me. I had depression, anxiety disorder and panic attack disorder. I had tried many other medications, gained 50lbs, and was still mentally a mess. I had to take over a year off of school because I couldnt handle the stress. I started Pristiq and within a week i noticed I was no longer crying at the drop of a hat, was better able to concentrate and was actually feeling so much better in my mood. Ive been taking it for over a year now, ive lost 40 of the 50lbs i gained on my previous medication, and im back at school and doing great. I credit Pristiq with all of my recovery. For the first 2 weeks of Prestiq i had a side effect of insomnia, but that went away after 2 weeks, it was no big deal."

10 / 10
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114 Report
  • Zyut
  • Taken for 5 to 10 years
  • January 26, 2014

"After a severe injury in the workplace, I hit rock bottom, depressed, suicidal, hopeless, really sad. I didn't understand what was going on, like someone else was at the wheel and I had to go along on this scary ride. I needed help so went to a psychiatrist who diagnosed clinical Depression, this was a relief to hear and separated me from the weirdo driving! Took 2 years of counseling and different medicines to find the right one, for me it is Pristiq. I have been on it for 8 years and now work full time. I think it takes a while for the user to live with an anti-depressant medication, I read and hear of many who want out after 2-4 years, but I found that just hanging in there is the way to go. I see myself as complete now, no side effects."

8 / 10
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125 Report
  • Fer
  • Taken for 2 to 5 years
  • April 4, 2022

"Don't suffer! I started with a severe depression & anxiety, I used to have terrible panic attacks & anxiety episodes, going through the day was tremendously hard and couldn't wait to be back home to sleep at 6pm.... I was having a terrible time and getting used to calm my anxiety with alcohol, I was afraid of starting on meds but when I discovered that I was coping with anxiety through alcohol I got very scared as there is alcoholism at my family so I started with Pristiq. I had what expected, dry mouth and a lot of thirst (the good side is that you get super hydrated), Lost appetite so I needed to force myself to eat and avoid sugar lows specially when working out, by the third month I started to feel alive again, I started to enjoy other people's company, I know sounds cliché but I started to see bright colors again... don't suffer!"

10 / 10
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38 Report
  • My...
  • Taken for 10 years or more
  • February 17, 2024

"After 40 years of therapy and various drug protocols, my PCP insisted we try this med. I would have to check with Dr., but am now 69 years old and since the start of Pristiq at age 44, it has allowed me to live a normal and balanced life, with no negative side effects. We are celebrating 44 years of marriage and are more in love every year thanks to eliminating a family plague."

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  • Feeling...
  • Taken for 1 to 2 years
  • November 23, 2019

"Ive been on Pristiq for over a year now. I understand it doesn't work for everyone, but I fully think it saved my life. I used to be between so many medications, and I fully think that this will be the one for me. The biggest thing it helped me do was remove the obsessive side of my depression and removing the CONSTANT invasive terrible thoughts. The side effects have just been kind of annoying. You definitely HAVE to be on top of taking it though. That's what keeps it from getting a 10/10 in my opinion. Overall its definitely worth trying."

8 / 10
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65 Report
  • vmart
  • Taken for 1 to 6 months
  • March 12, 2014

"I rated Pristiq a 9 for the simple fact that although it was really helped me get out of depression, I have been having crazy vivid dreams. The dreams are not pleasant, or bad, just weird. I have flashbacks about them all through the day, and I can recall almost every little detail. Some might argue that this is not a bad side effect, however, because of this, I've been having poor sleep. All this said, it wouldn't be a reason for me to get off the medication. It has really given me back my life!"

9 / 10
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119 Report
  • Miss-...
  • Taken for 1 to 6 months
  • February 8, 2015

"Pristiq is awesome so far.Don't reject it bcs it is nearly identical to Effexor. Effexor caused extreme sweating.I would stand in front of a forceful fan while dressing, and still be drenched!My doc told me I might not have that with pristiq and I don't! I am just over 6 weeks, and it took a full 4 weeks to kick in.The first couple of days I felt great, calm and happy, and got hopeful, but then slid back into the dark place.But I kept going and at 4 wks I suddenly one day woke up and started planning fun outings for my teen, after months of sofa lounging. 100mg, F, 56, 135lbs.Tried prozac (allergic), paxil (weight gain), effex (sweating), lexapro (out of dark place, but flat).I hear it's hell to stop, but I'm not going to stop. Why wld I?"

10 / 10
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111 Report
  • Sadno...
  • December 30, 2009

"I've been dealing with depression for a few years recently it had gotten so bad that suicidal thoughts and social withdrawal were really concerning me. I tried to fight it naturally by taking Super B Complex but to no avail. Within the last month and a half I've tried Lexapro which did not work for me and now Pristiq which I must say is really helping me. I'm finally having sex again with my husband. I didn't know that it was depression that was hindering me and having an orgasm is not a problem at all. In fact I've become quite frisky. A lot more talkative and beginning to get together with friends again without as much anxiety. Anxiety is not completely gone yet but it's only been two weeks. Loving it!"

7 / 10
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148 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.