The following information is NOT intended to endorse drugs or recommend therapy. While these reviews might be helpful, they are not a substitute for the expertise, skill, knowledge and judgement of healthcare practitioners in patient care.
I have tried dozens of antidepressants in the past. None of them really worked for me. In 2009 I saw a new doctor who prescribed Pristiq. The beginning side effects weren't great, I had increased anxiety, night sweats, and trouble sleeping. The side effects only lasted the first week. I recently changed insurance and my copay was quite high, so my doctor decided to try something cheaper, which was Wellbutrin. I was on that for 8 weeks and I never felt worse in my life! I cried all the time, constantly feeling the fight or flight response. The anxiety was unbearable. Recently had my doctor put me back on the Pristiq and all is well. Worth the copay!
46 users found this comment helpful.
20 yo female. I had my first dose at 50mg this morning. After battling depression and anxiety for about 3 years, I made the choice to start meds when it became too much to bear. What I can tell you about my day is that it's been an experience! Feeling foggy, dizzy, slightly nauseous. The strangest side effects were the extreme hour long high, fidgeting, and a huge compulsion to clench my jaw/grind my teeth. Regardless of the side effects (remembering it is only day one) I have felt not only happiness, but joy, comfort, and decreased anxiety. Before today I can't remember the last time I had a good laugh.
71 users found this comment helpful.
Review by Monkenbak (taken for less than 1 month):
Been on this for about a week. So far the pros are: I am much calmer. I have a very stressful job that used to have me yelling and wanting to pull my hair out. Now I'm calmly discussing issues with a reasonable mind. Also I noticed I have more energy and much more positive outlook on life. I've even lost a few pounds because my appetite is somewhat suppressed. The cons are: very vivid dreams. Just about every night I have a very lucid and lengthy dream about something in my life. Another con is the first few days I felt a little "out of it" as others have said, but that stopped after about 3-4 days. The last con is that it's expensive. I have two insurances and still had a copayment. But I like it so much, it's worth the price.
65 users found this comment helpful.
This medication is amazing! After 3 days of being extremely sick, I started to feel amazing, I am now 1 month into it and am so happy all the time and have no depressive thoughts at all. It kind of blocks out any sad thoughts. Works perfectly for me.
78 users found this comment helpful.
I was on Prozac and it wasn't working anymore. I tried Pristiq and for the first couple of weeks I didn't feel "right". Then, I started feeling much better. I also take a prescribed supplement called Deplin because my body doesn't absorb folic acid- a source of my depression. I don't know if it's the Deplin, the Pristiq or both, but I don't get depressed anymore. I do get kind of "mean" when I drink coffee with it. My sex drive is loooooow and achieving orgasm is difficult. I also suffer from dry mouth at night. But, I'm here to rate the medication on how well it helped my depression and it helped so very much. It's expensive, even with insurance.
41 users found this comment helpful.
I love this. I used to have major mood swings. I feel so much happier. I'm a recovering meth addict. I started this medicine in rehab. 6 months at 50mg and life couldn't be better. All of the anxiety and nerves, tics and repetitive thoughts I no longer have. Pristiq and AA saved my life.
86 users found this comment helpful.
Best medication EVER! After 2 years of feeling angry and upset and constantly fighting with my husband (over stupid things) and having suicidal and self harm thoughts purely from severe depression, I am now feeling 100% absolutely fantastic ALL the time thanks to Pristiq! Before I could barely get out of bed now I have heaps of energy to last all day and am constantly on the go. I LOVE how this medication makes me feel. I'd highly recommend trying this antidepressant.
87 users found this comment helpful.
I have suffered from anxiety and mood swings most of my life. But since my divorce and living alone the depression was becoming debilitating..... Feeling paralyzed by fear and barely functioning by taking Xanax. Friends and family were very concerned that I was going to drop off the edge. I am highly sensitive to medication. And having tried over 1/2 dozen antidepressants with side effects, I thought I was doomed to a life of torment. A friend was taking it and liked it, So, I tried it. I did have side effects in the beginning. Nausea, loss appetite, racing heart but most are now gone. I still clench some and my jaw gets sore. But I am so much better! 4 months was a big turning point for me. So don't lose hope!
67 users found this comment helpful.
My doctor prescribed Pristiq to help me deal with overwhelming grief after death of my son. I never took any antidepressants before, so I have nothing to compare it with. It worked very well for me, after taking it for just 3 days,without major side effects. I don't cry everyday like I used to, but also feel somewhat emotionally numb. I am calmer, happier and able to go on with my life.
55 users found this comment helpful.
20, female. I've been taking 100mg for 18 months I feel a lot better than what I did in regards to my depression but I feel nauseous 70% of the time and if I accidentally forget a pill I feel absolutely awful. Bizarre dreams, incredibly tired, diarrhea and paresthesia. I'm afraid to stop taking it for good because of what it does to me, something I'll be discussing with my doctor.
30 users found this comment helpful.
I have been off and on meds for many years, I thought 120mg of Cymbalta a day was working, then I went to see another DR about racing thoughts and ways that I could end my life. So the DR and I went over my protocol with a fine tooth comb and he moved some things around. He put me on Pristiq (oh great another one to try) but this was different. I started with 50 mg and then to 100 mg within 48 hours. He also added Valium 10 mg 4 times a day and I feel great. Everything is changing for the good and I hope that you talk with your DR about this. The only thing bad I can say about this medicine is that I wished that I had found it sooner.
62 users found this comment helpful.
I'm 22, and my doctor changed me from Effexor to Pristiq for my OCD and OCPD. Most noticeable side effect is definitely the appetite loss, but I don't seem to be losing much weight thankfully. If I'm busy and don't think about it, I go all day without food- it's nuts. Also I am having a lot of headaches, but I cannot be sure its the medicine. I sweat A LOT on this, and if I take it too late in the day I cannot sleep. My OCD seems to be in check- much better than Effexor. I've been taking 50 mg for 5 months now.
33 users found this comment helpful.
I switched from Effexor when Pristiq became available at the suggestion of my psychiatrist. Effexor was an improvement on my previous medication but I still suffered some anxiety and I experienced increased sweating. Pristiq seems to have reduced my anxiety levels and the sweating may have eased slightly and also, my mood improved. More recently I have also been prescribed dextroamphetamine (for ADHD), which improved my mood further, enabling me to halve my daily dose of Pristiq to 100 mg. I did this with the aim of reducing my sweating coming into summer (I am a resident of Sydney, Australia where the summers are typically hot and humid).
21 users found this comment helpful.
I was suffering severe depression from a total inability to cope with a traumatic situation I had been through. Pristiq worked wonders the first couple of weeks. I was enjoying life again. Silly me, I didn't pay any attention to the side effect information. It all started with significant weight loss 25 lbs. I originally weighed 120lbs, then I stopped sleeping. I became panicked, one pupil became very dilated. Terrible situation.
32 users found this comment helpful.
After suffering from mild depression and anxiety, I was much anticipated to use this medicine to help me. I have to date been on this medicine for close to 5 weeks, and I can say the first two-three weeks may have been hard to get through, but I managed, and I can happily say; this may be the best medicine on the market for fighting/ combating depression! I can't remember the last I have felt like this! Thank you Pristiq for bringing me back to what I used to be!
69 users found this comment helpful.
I have been on many medication for depression with associated panic attacks. Nothing has worked but since my doctor prescribed me Pristiq CR 50 mg and I can now officially say it's changed my life! I'm a survivor of many tragic events and feel like I'm not a victim anymore. I do clench my teeth more often but so what this side effect is nothing to compare to my unwillingness to live! Give it time, three months or more you'll feel better I promise!
58 users found this comment helpful.
I took one 50mg tab of Pristiq. 12 hours later, I ended up in the ER with heart rate of 140, BP of 198/102. ER admitted me to the hospital. I then had 3 episodes of my heart pounding in my chest and reaching a peak of 150 beats in a matter of seconds and then going back down. For many this medicine is a good thing, for me it was a nightmare.
20 users found this comment helpful.
I am a 48 yr old woman diagnosed with depression & chronic fatigue. Took Pristiq for 4 months. My entire system was taxed! I became very angry, argumentative over-reacting to mostly everything, communicating ineffectively, raging, I never relaxed - insomnia! Major increase in pain, muscle spasm, migraines!,involuntary muscle movement, etc.! Getting off of it was a nightmare! More than a week of constant 24 hr. sickening withdrawal- vomiting, dizziness, confusion, severe pain muscle spasm migraines depression thoughts that I would never make it through! The only thing that helped was Prozac-20mg Vicodin-5-300 & Tramadol-50mg as needed to Break Pain Cycle!
24 users found this comment helpful.
I've been on Pristiq for 18 months 100mg. It took 4 to 5 weeks to help me have a relaxed outlook on life. I still have a lot of the side effects you are all talking about. If I forget to take the pills for a day or two I fall straight back to the place I was.
23 users found this comment helpful.
I was treated for depression with Pristiq for a little over a year. I had previously tried multiple other antidepressants, to no avail. Once I started taking Pristiq I felt like a whole new person. I was energetic when I woke up, I had increased motivation, and I was finally happy. The side effects were minimal. When I first began taking it, I slept a lot more than usual, which almost made me quit taking it. I lost about 20 pounds in the first few months. The one negative that I experienced was the clenching of my jaw. In the mornings I could barely open my mouth because my jaw was so tight from clenching it shut all night. I eventually was at a point in my life where I felt that I no longer needed medication, and went off of Pristiq.
48 users found this comment helpful.
I tried many other medications without help. I was so depressed and anxious I could not live my life. Pristiq is the the only thing that has helped. I am living life now with out being in a deep depression and without anxiety. The only problem is I have gained 30 pounds since starting Pristiq a year ago. I do work out, but I still gain weight. I hate the weight gain, but like living my life now.
27 users found this comment helpful.
Drugs.com provides accurate and independent information on more than 24,000 prescription drugs, over-the-counter medicines and natural products. This material is provided for educational purposes only and is not intended for medical advice, diagnosis or treatment.
Data sources include Micromedex™ (updated Mar 13th, 2014), Cerner Multum™ (updated Apr 15th, 2014), Wolters Kluwer™ (updated Apr 3rd, 2014) and others. To view content sources and attributions, refer to our editorial policy.