Desvenlafaxine Pregnancy and Breastfeeding Warnings
Desvenlafaxine Pregnancy Warnings
Patients should be advised to notify their physician if they become pregnant or intend to become pregnant during therapy. It should be noted that, in some cases, the clinical picture is consistent with serotonin syndrome. When treating a pregnant woman with desvenlafaxine during the third trimester, the physician should carefully consider the potential risks and benefits of treatment.
Desvenlafaxine has been assigned to pregnancy category C by the FDA. There are no controlled data in human pregnancy. Neonates exposed to SNRIs (Serotonin and Norepinephrine Reuptake Inhibitors), or SSRIs (Selective Serotonin Reuptake Inhibitors), late in the third trimester have developed complications requiring prolonged hospitalization, respiratory support, and tube feeding. Such complications can arise immediately upon delivery. Reported clinical findings have included respiratory distress, cyanosis, apnea, seizures, temperature instability, feeding difficulty, vomiting, hypoglycemia, hypotonia, hypertonia, hyperreflexia, tremor, jitteriness, irritability, and constant crying. Desvenlafaxine should be used during pregnancy only if the potential benefits justify the potential risks.
Desvenlafaxine Breastfeeding Warnings
Desvenlafaxine is excreted into human milk. Because of the potential for serious adverse reactions in nursing infants from desvenlafaxine, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug to the mother. Desvenlafaxine should only be administered to breastfeeding women if the expected benefits outweigh any possible risk.
Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and Drugs.com is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.