Skip to main content

Azithromycin for Sinusitis User Reviews (Page 2)

Brand names: Zithromax, Azithromycin Dose Pack, Z-Pak

Azithromycin has an average rating of 6.7 out of 10 from a total of 139 reviews for the treatment of Sinusitis. 56% of reviewers reported a positive experience, while 24% reported a negative experience.

Reviews for Azithromycin

  • Kelsey...
  • June 19, 2015

"I was prescribed azrithromycin by my Dr for sinusitis. I have suffered from year-long allergies since I was a kid & this year has definitely been a bad one for me. I was a little worried about taking this medication because I read that some people got bad stomach upset with it. Luckily enough, the worst thing that happened to me was minor lower abdominal cramps, no worse than menstrual cramps. By the time I woke up the next day I was able to breathe clear for the first time literally in months. I did not feel congested, although I did have a very minor sore throat that I believe was caused by my sinuses finally draining. I definitely recommend taking this drug with food --it helps avoid stomach upset or cramps. Otherwise this helped me"

8 / 10
Was this helpful?YesNo
31 Report
  • Anonymous
  • August 27, 2009

Zithromax (azithromycin) "I was prescribed Zithromax for an upper respiratory infection and I did not have such a good experience. The first day I had really bad diarrhea. I couldn't even leave the house. The 2nd day I was overwhelmed with nausea. I took the pill with food and still felt sick to my stomach the entire day and night. Today I have decided the terrible side effects are not worth it, and I'm not going to take the rest of my prescription."

5 / 10
Was this helpful?YesNo
44 Report
  • Anonymous
  • June 17, 2011

Azithromycin Dose Pack (azithromycin) "Although there should be no negative drug interaction with this antibiotic and other medication I take daily, I had a severe allergic reaction: swelling of throat and tongue, vertigo and dizziness, bad taste in my mouth (even days after) and vomiting. I'm on my third day of the medication now and still feel sick and "weird". My throat and tongue are no longer swollen, but all my muscles hurt and my skin feels painful, also major headache and very sleepy. "

6 / 10
Was this helpful?YesNo
37 Report

Frequently asked questions

  • Ocean...
  • Taken for less than 1 month
  • February 11, 2019

Azithromycin Dose Pack (azithromycin) "I've taken this for every URI I've ever had and feel better after first dose. No side effects. I love it. My new doctor won't prescribe it for me for some reason. Well, she's either a PA or a NP. That may have something to do with it. I know what works and is easy to take and doesn't RIP my guts out and keeps working long after the last dose is taken. I highly recommend this"

10 / 10
Was this helpful?YesNo
18 Report
  • Anonymous
  • August 12, 2011

Zithromax (azithromycin) "Z-Pak was given to me during a walk-in-care visit. 7 days after starting, my condition has not improved. I experienced several side effects, including nausea, diarrhea, fever, sweating, and more. The worst of all is the loss of appetite caused by the medication. I have only had about 2 days worth of meals in the last five and still cannot stomach a full meal."

1 / 10
Was this helpful?YesNo
35 Report

Are you taking this medicine?

  • Hezbutt
  • December 28, 2016

Zithromax (azithromycin) "I'm 35 and have had sinus infections as long as I can remember. Prior to my allergy shots I was getting them 3-4x a year. Z-PAC is my favorite and it cures it quickly. Once in a blue Moon I'll need another round though. But lately my doctors have said the bacteria has been resistant to it and I've used another medication and though it works it takes so much longer. I'm happy to say that I'm Told The bacteria this year isn't supposed to be as resistant to it. For all the ladies, you may want to ask for yeast infection meds before you leave the doctors office. For me It never fails."

8 / 10
Was this helpful?YesNo
23 Report
  • NC Re...
  • Taken for less than 1 month
  • April 15, 2015

"Did great job of treating a sinus infection, where I had pounding headaches all day for 48 hours prior to use. By day 2, I was significantly better. One issue is that two pills on day 1 did wipe out bacteria in the gut. I wish pharmacist gave me a heads up. In hindsight, I would have spaced first 2 pills out by at least 12 hours. Took one pill at 4pm and another at 8pm. By day 2 was fine, but I did need a probiotic and immodium to get through the first night."

9 / 10
Was this helpful?YesNo
26 Report

More FAQ

  • Anonymous
  • September 9, 2011

Zithromax (azithromycin) "I have had this sinus infection for 5 days. Went to the doctors yesterday the doctor prescribed me Zithromax. The side effects with me are stomach cramps, diarrhea, bloody nose and dizziness. But it seems to be working so far. Lets hope that by time the bottle is finished I feel like myself again."

10 / 10
Was this helpful?YesNo
32 Report
  • Kimmi...
  • January 1, 2017

"I get a very bad sinus infection every year. This year as soon I as I felt in coming on (day 4) thats early for me, I went to an urgent care. Doctor confirmed it was a sinus infection and have me the Z Pack. First day is 2 pills with 1 pill for next 4 days. After 12 hours of taking first 2 pills I felt so much better. I will continue to take the remaining pills and from now on I will get to a doctor early on and request Z Pack. I highly recommend it."

8 / 10
Was this helpful?YesNo
21 Report
  • marym...
  • Taken for less than 1 month
  • March 8, 2016

"I went to see doctor finally after 100+ days of sinusitis...just thought it was a persistent cold. No bad side effects, at all, but not as effective as I had hoped. First day (2 doses) I felt improvement after 4 hours. Day 2 unfortunately, all symptoms worsened (congestion, headache, ear pressure, postnasal drip, coughing). Day 3, symptoms became worse still. Day 4 was nearly unbearble with the worst headache I have had in my 66 years. Ears felt as if filled with fluid. Not able to sleep at all at night, even with head in elevated position. Today is Day 5, and I've taken the final dose. There is some improvement today, and the package asserts that the antibiotic will keep working for Days 6-10, even though no more doses will be taken."

6 / 10
Was this helpful?YesNo
20 Report
  • Ericf...
  • Taken for less than 1 month
  • November 13, 2015

Zithromax (azithromycin) "The day one two pills does tend to wipe out the bacteria in my gut. After having stomach issues on the first night of the first time, I do take a probiotic and one immodium at night. First time I took this it wiped the infection in 48 hours. Second time 11 months later it did not work quite so well. Infection greatly decreased but did come back 5 days later. I think part of the problem was that I still had a virus and mold allergy problems from rain as well as an infection so had trouble eliminating congestion. I took a 5 day dosage and did have symptoms reoccur in a week. I do think it would have worked better if I had not had these additional issues related to a virus and allergies."

8 / 10
Was this helpful?YesNo
20 Report
  • BobRB
  • Taken for less than 1 month
  • November 14, 2015

"On my 2nd package of 5 day Z pack, it is working but slow to act. This is a bad infection, it had been on and off for past 6 months. I will need another refill today or my Dr. may try another option. I can not take any cyllin drugs. This sinusitis is a chronic problem. I was experiencing this problem almost yearly every fall/winter then stopped for past 5 years. Now it is back with vengeance..."

8 / 10
Was this helpful?YesNo
20 Report
  • Chris
  • Taken for less than 1 month
  • December 11, 2023

"I guess this is the issue I was having. My lymph nodes in my neck would swell. I was on another Z-Pak before this one. It worked, finished it, then within a week it was back! My daughter and I both went to the doctor yesterday and we were prescribed Azithromycin. Let me tell you, I feel so much better – first night of sleep in 4 months. Lymph nodes are not swollen after the initial dose! Woke up today with a running nose and sneezing, so it's working! I will definitely keep this medication in mind if this issue comes back! My daughter still feels horrible, but she had more symptoms than I did. I will say her cough has slowed and her fever is staying on the low side of 100.8, instead of 103! Lots of fluids with this medication or you will have a dry throat. But I'm overall very happy with this medication!"

10 / 10
Was this helpful?YesNo
2 Report
  • Anonymous
  • Taken for less than 1 month
  • October 16, 2017

"I usually get 2-3 sinus infections a year, usually starts with a cold then comes the sinus infection. Azithromycin is a miracle drug for me. I was seen by Dr today and the pain was so intense it caused my blood pressure to be high, she prescribed me zpack and within hours after taking the initial dose the pain is 50% less. I do not have any side effects from the medicine and it is the only prescription drug that works this well on my sinus infection"

10 / 10
Was this helpful?YesNo
16 Report
  • Anonymous
  • January 19, 2010

"My 10 year old had a right ear infection and was prescribed Azithromycin. He took the first 2 pills which totaled 500 mg and within 30 minutes he was vomiting, having diarrhea and chest pains. We took him to the ER where we were told there was at least a 5 hour wait and decided to take him back home and give him a lot of liquids to try and flush this out of his system. My advice, don't give a child 15 and under more than 250 mg."

Was this helpful?YesNo
28 Report
  • Roger
  • Taken for 10 years or more
  • September 22, 2020

Azithromycin Dose Pack (azithromycin) "I’ve taken this Azithromycin Dose Pack twice a year for about fourteen years for sinusitis and never had a problem with it, always worked great without any side effects. When I started taking it this time around the headaches were so bad and the diarrhea and loose stool is unbelievable so after four days I’ve stopped and won’t take the last pill that’s how bad the side effects are this time. I know one day more for the last pill would be silly to stop but I just can’t handle the side effects any longer. The brand that the pharmacy gave me this time is a different brand so that may have something to do with it, the pharmacy I used for years has closed down so the other one has different pills or brands for the same meds. I’ve always said a pill is just a pill and it doesn’t matter what brand it is but after this I changed my mind completely on that."

1 / 10
Was this helpful?YesNo
10 Report
  • CTsuf...
  • April 6, 2016

"I was prescribed the 500mg pill 1x a day for 3 days (for my sinus infection). I took pill #1 at 2pm with my lunch. By 5pm, my stomach started to gurgle and groan. By 6pm, the diarrhea started. It was awful! I say it's a nightmare second only to the colonoscopy prep kit I had six months ago! I must've been on the toilet 6x in an hour and a half. I was cold, shivering, nauseated, and exhausted. I'm absolutely not continuing this treatment. :("

1 / 10
Was this helpful?YesNo
18 Report
  • Tfs...
  • Taken for less than 1 month
  • March 29, 2023

Zithromax (azithromycin) "Works very quickly, just don’t try to fart.!!! Cause it isn’t a fart! Diarrhea kicked in after first double dose. I have IBS and ptsd so my gut is a roller coaster most times so I recommend probiotics two hours after taking. Good luck everyone."

Was this helpful?YesNo
4 Report
  • south...
  • Taken for 5 to 10 years
  • April 17, 2019

"I'd be lost without this medication. I get a few real bad sinus infections per year, and they put me down and out 100%. Azithromycin is the only thing that will get rid of them. My doctor knows this, and we don't even try alternatives. Within 1 day after the first dose, I feel relief. Generally, no side effects, other than some stomach upset, a sometimes slight nausea. Understanding, antibiotics kill all the good bacteria in your GI system, I don't think there is an antibiotic that won't give you GI symptoms. Without a doubt, take this with food, and the side effects are not as bad. Affordable, easy, effective."

10 / 10
Was this helpful?YesNo
12 Report
  • Anonymous
  • April 30, 2009

Zithromax (azithromycin) "I started the pack on Sunday and experienced diarrhea and mild itchiness. I'm on my last day and I'm feeling really good. This medicine seemed to work very well. I was hesitant at first, but it seems to clear things up very well."

10 / 10
Was this helpful?YesNo
27 Report
  • Rjff
  • November 16, 2015

"I have taken this medicine many many times before and it has alway worked with no problems.I have had serious stomach issues this time around..slightly since day one..tonight is day 4 and I just experienced severe abdominal cramping and pain....loose stools (tmi)..so severe I though I would have to go to ER..started about 10 minutes after taking athe pill. .not on a empty stomach Iate about 1 hour prior...maybe just a freak think but very scary..a few hours went by and I'm starting to feel better...not sure if I will take last pill l tomorrow"

10 / 10
Was this helpful?YesNo
17 Report
  • No Ni...
  • December 14, 2016

"I have chronic sinusitis, so I usually treat it with nasal/sinus rinses (saline) and good basic hygiene. But occasionally it gets bad and stays bad for 7 or more days, in which case a run of antibiotics always helps. I use the one-pill-a-day-for-three-days Azithromycin, as it always works and is most convenient. No side effects, and I usually start feeling better after the second day. I try to avoid doing this too often, as I'm aware of bacterial resistance issues. I've learned over the years to know the difference between allergies, colds and bacterial infection, so I don't overuse or abuse the antibiotic. I've never had the diarrhea or stomach cramping described by some."

10 / 10
Was this helpful?YesNo
15 Report
  • Elclw
  • February 14, 2017

"Sinus pressure and infection, got Zpack for the first time ever. One week later and my sinuses are still clogged, headache lasted 5 days and feels like it will reoccur. Diarrhea every day. Tried every single homeopathic way to beat this feeling. Still can't sleep well and nose runs. This sucks."

4 / 10
Was this helpful?YesNo
15 Report
  • tigge...
  • Taken for less than 1 month
  • June 25, 2015

Azithromycin Dose Pack (azithromycin) "re: side effects, I forgot to add to the comments I just submitted that while my stomach felt a little weird the morning after my first dose (this being 12 hours later) I was prepared to eat plenty of probiotics, which I have been doing. I have not had any problems; I am really pushing the yogurt and kefir. I did feel extraordinarily tired but not debilitated, and I was extremely fatigued from nearly 5 weeks of being sick, so the trade-off is meaningless, and it's improved after the first mega-dose anyway."

10 / 10
Was this helpful?YesNo
17 Report
  • sinus...
  • November 5, 2009

Zithromax (azithromycin) "I get sinusitis several times a year. The old-fashioned 5-day Z-packs used to work really well for me. They still do "knock down" the worst of it (I carry a filled prescription from my doctor when I'm traveling on business) ... but in the past several years I've noticed that sometimes the sinusitis will rebound in a couple of weeks and I end up having to take a different type of antibiotic. Unfortunately, those secondary antibiotics tend to get to me -- queasy stomach, the "taste" of the medicine even hours later. None of that with Zithromax. The only time I had a bad experience with Zithromax side effects was the three-day pack."

8 / 10
Was this helpful?YesNo
23 Report

Reviews may be edited to correct grammar/spelling or to remove inappropriate language and content. Reviews that appear to be created by parties with a vested interest are not published. This information is not intended to endorse any particular medication. While these reviews may be helpful, they are not a substitute for the expertise, knowledge, and judgement of healthcare professionals.

Learn more about Sinusitis

Care guides

Symptoms and treatments

Medicine.com guides (external)