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Streptomycin

Pronunciation

Generic Name: streptomycin (strep-toe-MY-sin)
Brand Name: Generic only. No brands available.

Severe toxic nerve reactions are possible for patients with kidney problems who use this medication. Kidney function and complete blood counts should be closely monitored by a health care provider while taking this medication. Appropriate medical equipment should be available for patients taking this medication.


Streptomycin is used for:

Treating tuberculosis (TB) and infections caused by certain bacteria.

Streptomycin is an aminoglycoside. It works by killing sensitive bacteria by stopping the production of essential proteins needed by the bacteria to survive.

Do NOT use streptomycin if:

  • you are allergic to any ingredient in streptomycin or other similar medicines
  • you are taking a nondepolarizing muscle relaxant (eg, pancuronium)

Contact your doctor or health care provider right away if any of these apply to you.

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Before using streptomycin:

Some medical conditions may interact with streptomycin. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have diarrhea, eighth cranial nerve impairment, stomach or intestinal infection, or kidney failure
  • if you are dehydrated (excessive diarrhea, nausea, or vomiting causing an electrolyte imbalance)
  • if you have muscle weakness or Parkinson disease

Some MEDICINES MAY INTERACT with streptomycin. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Fludarabine, indomethacin, or polypeptide antibiotics (eg, polymyxin B) because the actions and side effects of streptomycin may be increased
  • Cyclosporine, methoxyflurane, nonsteroidal anti-inflammatory drugs (NSAIDs) (eg, ibuprofen), nitrosoureas (eg, streptozocin), parental cephalosporins (eg, cephalexin), or parenteral vancomycin because toxicities to the kidneys may occur
  • Loop diuretics (eg, furosemide) because eighth cranial nerve damage, causing severe, permanent hearing loss, may occur
  • Nondepolarizing muscle relaxants (eg, pancuronium), polypeptide antibiotics (eg, polymyxin B), or succinylcholine because the actions and side effects of these medicines may be increased

This may not be a complete list of all interactions that may occur. Ask your health care provider if streptomycin may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use streptomycin:

Use streptomycin as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Drinking extra fluids while you are taking streptomycin is recommended. Check with your doctor for instructions.
  • Streptomycin is usually administered as an injection at your doctor's office, hospital, or clinic. If you are using streptomycin at home, carefully follow the injection procedures taught to you by your health care provider.
  • In adults, the preferred place of injection is the upper right portion of the buttock or the middle portion of the thigh. In children, the preferred place of injection is the middle portion of the thigh.
  • The place of injection should be alternated.
  • If streptomycin contains particles or is discolored, or if the vial is cracked or damaged in any way, do not use it.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Dispose of properly after use. Ask your doctor or pharmacist to explain local regulations for proper disposal.
  • To clear up your infection completely, continue using streptomycin for the full course of treatment even if you feel better in a few days.
  • If you miss a dose of streptomycin, contact your doctor immediately.

Ask your health care provider any questions you may have about how to use streptomycin.

Important safety information:

  • Streptomycin may cause dizziness or lightheadedness. Do not drive, operate machinery, or do anything else that could be dangerous until you know how you react to streptomycin. Using streptomycin alone, with certain other medicines, or with alcohol may lessen your ability to drive or perform other potentially dangerous tasks.
  • Streptomycin is effective only against bacteria. It is not effective for treating viral infections (eg, the common cold).
  • It is important to use streptomycin for the full course of treatment. Failure to do so may decrease the effectiveness of streptomycin and increase the risk that the bacteria will no longer be sensitive to streptomycin and will not be able to be treated by this or certain other antibiotics in the future.
  • Long-term or repeated use of streptomycin may cause a second infection. Your doctor may want to change your medicine to treat the second infection. Contact your doctor if signs of a second infection occur.
  • Before you have any medical or dental treatments, emergency care, or surgery, tell the doctor or dentist that you are using streptomycin.
  • LAB TESTS, including kidney function and complete blood cell counts, may be performed to monitor your progress or to check for side effects. Be sure to keep all doctor and lab appointments.
  • Use streptomycin with caution in the ELDERLY because they may be more sensitive to its effects.
  • Use streptomycin with extreme caution in INFANTS. Safety and effectiveness in this age group have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: Streptomycin has been shown to cause harm to the fetus. If you become pregnant, discuss with your doctor the benefits and risks of using streptomycin during pregnancy. Streptomycin is excreted in breast milk. Do not breast-feed while taking streptomycin.

Possible side effects of streptomycin:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Abnormal skin sensation around the face; feeling of whirling motion; fever; swelling.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); decreased urination; dizziness; headache; hearing loss; hives; lightheadedness; loss of balance; muscle weakness; nausea; numbness or tingling; ringing or roaring in the ears; skin rash or itching; vaginal irritation or discharge; vomiting.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include difficulty breathing; dizziness; lightheadedness; ringing in the ears.

Proper storage of streptomycin:

Store streptomycin at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep streptomycin out of the reach of children and away from pets.

General information:

  • If you have any questions about streptomycin, please talk with your doctor, pharmacist, or other health care provider.
  • Streptomycin is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take streptomycin or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about streptomycin. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to streptomycin. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using streptomycin.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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