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Streptomycin Pregnancy and Breastfeeding Warnings

Streptomycin Pregnancy Warnings

Streptomycin has been assigned to pregnancy category D by the FDA. Streptomycin crosses the placenta; reported cord concentrations have been equal to or less than the mother's serum concentration. There are no controlled data from human pregnancy studies; however, there are reports of fetal eighth cranial nerve damage with subsequent bilateral deafness. Most authorities, including the Centers for Disease Control and the American Thoracic Society, discourage the use of streptomycin during pregnancy due to the risk of fetal ototoxicity. Streptomycin should only be given during pregnancy when benefit outweighs risk.

Streptomycin Breastfeeding Warnings

Streptomycin is excreted into human milk. Due to poor oral bioavailability, systemic toxicity in the nursing infant is unlikely. Streptomycin is considered compatible with breast-feeding by the American Academy of Pediatrics.

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