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Streptomycin Pregnancy and Breastfeeding Warnings

Streptomycin Pregnancy Warnings

Streptomycin has been assigned to pregnancy category D by the FDA. Streptomycin crosses the placenta; reported cord concentrations have been equal to or less than the mother's serum concentration. There are no controlled data from human pregnancy studies; however, there are reports of fetal eighth cranial nerve damage with subsequent bilateral deafness. Most authorities, including the Centers for Disease Control and the American Thoracic Society, discourage the use of streptomycin during pregnancy due to the risk of fetal ototoxicity. Streptomycin should only be given during pregnancy when benefit outweighs risk.

See references

Streptomycin Breastfeeding Warnings

Streptomycin is excreted into human milk. Due to poor oral bioavailability, systemic toxicity in the nursing infant is unlikely. Streptomycin is considered compatible with breast-feeding by the American Academy of Pediatrics.

See references

References for pregnancy information

  1. Donald PR, Sellars SL "Streptomycin ototoxicity in the unborn child." S Afr Med J 60 (1981): 316-8
  2. CDC "Initial therapy for tuberculosis in the era of multidrug resistance. Recommendations of the advisory council for the elimintion of tuberculosis." MMWR Morb Mortal Wkly Rep 42 (1993): 1-8
  3. Woltz JH, Wiley M "Transmission of streptomycin from maternal blood to the fetal circulation and the amniotic fluid." Proc Soc Exp Biol Med 60 (1945): 106-7
  4. American Thoracic Society, Centers for Disease Control "Treatment of tuberculosis and tuberculosis infection in adults and children." Am Rev Respir Dis 134 (1986): 355-63
  5. Heilman DH, Heilman FR, Hinshaw HC, Nichols DR, Herell WE "Streptomycin: absorption, diffusion, excretion and toxicity." Am J Med Sci 210 (1945): 576-84
  6. Holdiness MR "Transplacental pharmacokinetics of the antituberculosis drugs." Clin Pharmacokinet 13 (1987): 125-9
  7. "Product Information. Streptomycin (streptomycin)." Pfizer US Pharmaceuticals, New York, NY.
  8. Mann JM, Moskowitz R "Plague and pregnancy." JAMA 237 (1977): 1854-5

References for breastfeeding information

  1. Briggs GG, Freeman RK, Yaffe SJ.. "Drugs in Pregnancy and Lactation. 5th ed." Baltimore, MD: Williams & Wilkins (1998):
  2. Committee on Drugs, 1992 to 1993 "The transfer of drugs and other chemicals into human milk." Pediatrics 93 (1994): 137-50
  3. "Product Information. Streptomycin (streptomycin)." Pfizer US Pharmaceuticals, New York, NY.
  4. Snider DE, Powell KE "Should women taking antituberculosis drugs breast-feed?" Arch Intern Med 144 (1984): 589-90

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