Generic Name: pantoprazole (pan-TOE-pra-zole)
Brand Name: Protonix I.V.
Pantoprazole is used for:
Short-term treatment (7 to 10 days) of patients with gastroesophageal reflux disease (GERD) who have a history of irritation of the esophagus. It may be used for conditions that cause your body to make too much stomach acid (eg, Zollinger-Ellison syndrome). It may also be used for other conditions as determined by your doctor.
Pantoprazole is a proton pump inhibitor (PPI). It works by decreasing the amount of acid produced in the stomach.
Do NOT use pantoprazole if:
- you are allergic to any ingredient in pantoprazole or to another PPI (eg, omeprazole)
- you are taking atazanavir, dasatinib, nelfinavir, or rilpivirine
Contact your doctor or health care provider right away if any of these apply to you.
Before using pantoprazole:
Some medical conditions may interact with pantoprazole. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have low blood potassium or magnesium levels, low blood vitamin B12 levels or vitamin B12 deficiency, liver problems, or stomach or bowel cancer
- if you have low blood zinc levels
- if you have osteoporosis (weak bones), a family history of osteoporosis, or other risk factors of osteoporosis (eg, smoking, poor nutrition)
Some MEDICINES MAY INTERACT with pantoprazole. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Diuretics (eg, furosemide, hydrochlorothiazide) because the risk of low blood magnesium levels may be increased
- Anticoagulants (eg, warfarin), digoxin, methotrexate, or saquinavir because the risk of their side effects may be increased by pantoprazole
- Ampicillins, atazanavir, bosutinib, clopidogrel, dasatinib, erlotinib, indinavir, iron, itraconazole, ketoconazole, mycophenolate, nelfinavir, nilotinib, posaconazole, rilpivirine, or sorafenib because their effectiveness may be decreased by pantoprazole
This may not be a complete list of all interactions that may occur. Ask your health care provider if pantoprazole may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use pantoprazole:
Use pantoprazole as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- Pantoprazole is usually given as an injection at your doctor's office, hospital, or clinic. If you will be using pantoprazole at home, a health care provider will teach you how to use it. Be sure you understand how to use pantoprazole. Follow the procedures you are taught when you use a dose. Contact your health care provider if you have any questions.
- Do not use pantoprazole if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
- Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
- Pantoprazole should only be used for a short time (7 to 10 days) until you are able to take medicine by mouth. Discuss any questions or concerns with your doctor.
- If you miss a dose of pantoprazole, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use pantoprazole.
Important safety information:
- Pantoprazole may cause drowsiness or dizziness. These effects may be worse if you take it with alcohol or certain medicines. Use pantoprazole with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Do NOT change your dose, stop taking pantoprazole, or take pantoprazole for longer than prescribed without checking with your doctor.
- Contact your doctor if you have any symptoms of a bleeding ulcer, such as black, tarry stools or vomit that looks like coffee grounds; or if you experience throat pain, chest pain, severe stomach pain, or trouble swallowing.
- Pantoprazole may increase the risk of a serious form of diarrhea. Contact your doctor right away if stomach pain or cramps, severe or persistent diarrhea, or bloody or watery stools occur. Discuss any questions or concerns with your doctor.
- Pantoprazole may increase the risk of hip, wrist, and spine fractures in patients with weak bones (osteoporosis). The risk may be greater if you use pantoprazole in high doses or for long periods of time, or if you are older than 50 years old. Contact your doctor if you have any questions about this information.
- Low blood magnesium levels have been reported rarely in patients taking PPIs for at least 3 months. In most cases, this effect was seen after a year of treatment. If you will be taking pantoprazole for a long time, or if you take certain other medicines (eg, digoxin, diuretics), your doctor may perform lab tests to check for low blood magnesium levels. Seek medical attention right away if you experience symptoms of low blood magnesium levels (eg, dizziness; fast or irregular heartbeat; involuntary muscle movements; jitteriness or tremors; muscle aches, cramps, pain, spasms, or weakness; seizures).
- Long-term treatment (eg, longer than 3 years) with medicines like this one has rarely caused low vitamin B12 levels. Discuss any questions or concerns with your doctor.
- Check with your doctor to see whether you should take a calcium and vitamin D supplement while you use pantoprazole.
- Pantoprazole may interfere with certain lab tests. Be sure your doctor and lab personnel know you are taking pantoprazole.
- Pantoprazole should be used with caution in Asian patients; the risk of side effects may be increased in these patients.
- Use pantoprazole with caution in the ELDERLY; they may be more sensitive to its effects, especially hip, wrist, and spine fractures.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using pantoprazole while you are pregnant. Pantoprazole is found in breast milk. Do not breast-feed while taking pantoprazole.
Possible side effects of pantoprazole:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Gas; headache; joint pain; mild diarrhea or stomach pain; nausea; vomiting.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); bloody or watery stools; bone pain; chest pain; fast or irregular heartbeat; fever, chills, or sore throat; pain, redness, swelling, tenderness, or warmth at the injection site; red, swollen, blistered, or peeling skin; severe or persistent diarrhea or stomach pain; severe or persistent nausea or vomiting; stomach cramps; symptoms of kidney problems (eg, not able to pass urine, change in the amount of urine produced, blood in the urine, a big weight gain); symptoms of liver problems (eg, yellowing of the skin or eyes, dark urine, pale stools, nausea, loss of appetite, unusual tiredness); unexplained weight loss; unusual bruising or bleeding; vision changes.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.Proper storage of pantoprazole:
Pantoprazole is usually handled and stored by a health care provider. If you are using pantoprazole at home, store it as directed by your pharmacist or health care provider. Keep pantoprazole, as well as syringes and needles, out of the reach of children and away from pets.
- If you have any questions about pantoprazole, please talk with your doctor, pharmacist, or other health care provider.
- Pantoprazole is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take pantoprazole or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about pantoprazole. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to pantoprazole. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using pantoprazole.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
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