Pantoprazole use while Breastfeeding

Drugs containing Pantoprazole: Protonix, Protonix IV

Pantoprazole Levels and Effects while Breastfeeding

Summary of Use during Lactation

Limited information indicates that maternal pantoprazole doses of 40 mg daily produce low levels in milk and would not be expected to cause any adverse effects in breastfed infants.

Drug Levels

Maternal Levels. A mother who was 10 months postpartum and partially nursing her infant was given a single 40 mg dose of oral pantoprazole. Pantoprazole was detectable in milk only 2 and 4 hours after the dose with milk levels of 36 mcg/L and 24 mcg/L, respectively, at those times. It was not detectable (<10 mcg/L) in milk at 6, 8 and 24 hours after the dose. The authors estimated that a fully breastfed infant would receive 0.14% of the maternal weight-adjusted dosage.[1]

Infant Levels. Relevant published information was not found as of the revision date.

Effects in Breastfed Infants

Relevant published information was not found as of the revision date.

Possible Effects on Lactation

Relevant published information was not found as of the revision date.

Alternate Drugs to Consider

Cimetidine, Famotidine, Nizatidine, Omeprazole, Ranitidine, Sucralfate

References

1. Plante L, Ferron GM, Unruh M et al. Excretion of pantoprazole in human breast. J Reprod Med. 2004;49:825-7. PMID: 15568407

Pantoprazole Identification

Substance Name

Pantoprazole

CAS Registry Number

102625-70-7

Drug Class

  • Anti-Ulcer Agents

Administrative Information

LactMed Record Number

409

Information from the National Library of Medicine's LactMed Database.

Last Revision Date

2013-09-07

Disclaimer

Information presented in this database is not meant as a substitute for professional judgment. You should consult your healthcare provider for breastfeeding advice related to your particular situation. The U.S. government does not warrant or assume any liability or responsibility for the accuracy or completeness of the information on this Site.

See Also...

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