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Hyaluronidase

Generic Name: hyaluronidase (HYE-a-loo-RON-i-dase)
Brand Name: Hylenex

Hyaluronidase is used for:

Increasing the absorption of other injected medicines or fluids. It may also be used for other conditions as determined by your doctor.

Hyaluronidase is a protein enzyme. It works by causing rapid spreading of injected fluid into the body, which increases the absorption of injected fluids.

Do NOT use hyaluronidase if:

  • you are allergic to any ingredient in hyaluronidase
  • you are using it with alpha agonists (eg, clonidine), benzodiazepines (eg, alprazolam), dopamine, furosemide, or phenytoin

Contact your doctor or health care provider right away if any of these apply to you.

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Before using hyaluronidase:

Some medical conditions may interact with hyaluronidase. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have a skin infection or skin cancer

Some MEDICINES MAY INTERACT with hyaluronidase. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Local anesthetics (eg, lidocaine) because the risk of their side effects may be increased by hyaluronidase
  • Antihistamines (eg, diphenhydramine), certain hormones (eg, corticotropin, estrogens), cortisone, or salicylates (eg, aspirin) because they may decrease hyaluronidase's effectiveness
  • Benzodiazepines (eg, alprazolam), furosemide, or phenytoin because their effectiveness may be decreased by hyaluronidase

This may not be a complete list of all interactions that may occur. Ask your health care provider if hyaluronidase may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use hyaluronidase:

Use hyaluronidase as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Hyaluronidase is given as an injection at your doctor's office, hospital, or clinic.
  • Do not use hyaluronidase if it contains particles, is cloudy or discolored, or if the vial is cracked or damaged.
  • Keep this product, as well as syringes and needles, out of the reach of children and away from pets. Do not reuse needles, syringes, or other materials. Ask your health care provider how to dispose of these materials after use. Follow all local rules for disposal.
  • Hyaluronidase should not be applied directly in the eye, injected into a vein, or injected into skin that is infected, red, swollen, or irritated.
  • If you miss a dose of hyaluronidase, contact your doctor right away.

Ask your health care provider any questions you may have about how to use hyaluronidase.

Important safety information:

  • Hyaluronidase should not be used to enhance absorption of dopamine or alpha agonist medicines (eg, clonidine) or to reduce the swelling of bites or stings.
  • Caution is advised when using hyaluronidase in CHILDREN; they may be more sensitive to its effects.
  • PREGNANCY and BREAST-FEEDING: It is not known if hyaluronidase can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using hyaluronidase while you are pregnant. It is not known if hyaluronidase is found in breast milk. If you are or will be breast-feeding while you use hyaluronidase, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of hyaluronidase:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Redness or pain at the injection site.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue; unusual hoarseness); severe or persistent redness, pain, itching, or swelling at the injection site.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately.

Proper storage of hyaluronidase:

Hyaluronidase is usually handled and stored by a health care provider. If you are using hyaluronidase at home, store hyaluronidase as directed by your pharmacist or health care provider. Keep hyaluronidase out of the reach of children and away from pets.

General information:

  • If you have any questions about hyaluronidase, please talk with your doctor, pharmacist, or other health care provider.
  • Hyaluronidase is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take hyaluronidase or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about hyaluronidase. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to hyaluronidase. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using hyaluronidase.

Issue Date: April 2, 2014
Database Edition 14.2.1.001
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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