Vitrase

Generic Name: hyaluronidase (injectable) (HYE al ure ON i dase)
Brand Names: Amphadase, Hylenex, Vitrase

What is Vitrase?

Vitrase is a preparation of highly purified ovine testicular hyaluronidase, a protein enzyme. The exact chemical structure of this enzyme is unknown.

Vitrase (hyaluronidase) is used as an aid to increase the absorption and distribution of other injected medications in the body.

Vitrase is also used to help contrast dyes in your body show more clearly on certain types of x-rays or scans.

Important information

Your doctor may perform a skin test to see if you are allergic to hyaluronidase before you receive Vitrase.

Before receiving Vitrase, tell your doctor if you are using any of the following drugs: furosemide (Lasix); phenytoin (Dilantin); a sedative or anxiety medication (such as Valium, Xanax, Tranxene); aspirin or salicylates; cortisone or ACTH (Corticotropin); estrogens; or an antihistamine (such as a cold or allergy medicine).

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Before receiving Vitrase

You should not receive Vitrase if you are allergic to hyaluronidase.

Your doctor may perform a skin test to see if you are allergic to hyaluronidase before you receive Vitrase.

FDA pregnancy category C. It is not known whether Vitrase will harm an unborn baby. Tell your doctor if you are pregnant or plan to become pregnant while using this medication. It is not known whether hyaluronidase passes into breast milk or if it could harm a nursing baby. Do not use Vitrase without telling your doctor if you are breast-feeding a baby.

See also: Pregnancy and breastfeeding warnings (in more detail)

How should I use Vitrase?

Vitrase is injected under the skin.

A healthcare provider will give you this injection.

What happens if I miss a dose?

Call your doctor for instructions if you miss an appointment for your Vitrase injection.

What happens if I overdose?

Seek emergency medical attention or call the Poison Help line at 1-800-222-1222.

What should I avoid?

Follow your doctor's instructions about any restrictions on food, beverages, or activity while you are using Vitrase.

Vitrase side effects

Get emergency medical help if you have any of these signs of an allergic reaction to Vitrase: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Less serious Vitrase side effects may include pain, itching, redness, or swelling where the medication was injected.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.

See also: Side effects (in more detail)

What other drugs will affect Vitrase?

Before receiving Vitrase, tell your doctor if you are using any of the following drugs:

  • furosemide (Lasix);

  • phenytoin (Dilantin);

  • a sedative or anxiety medication (such as Valium, Xanax, Tranxene);

  • aspirin or salicylates;

  • cortisone or ACTH (Corticotropin);

  • estrogens; or

  • an antihistamine (such as a cold or allergy medicine).

This list is not complete and other drugs may interact with Vitrase. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor.

Where can I get more information?

  • Your pharmacist can provide more information about Vitrase injection.
  • Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Inc. ('Multum') is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum information has been compiled for use by healthcare practitioners and consumers in the United States and therefore Multum does not warrant that uses outside of the United States are appropriate, unless specifically indicated otherwise. Multum's drug information does not endorse drugs, diagnose patients or recommend therapy. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. Multum does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse or pharmacist.

Copyright 1996-2014 Cerner Multum, Inc. Version: 4.01. Revision Date: 09/14/2010 9:27:22 AM.

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