Hyaluronidase Side Effects
Brand Names: Amphadase, Hylenex, Vitrase
Please note - some side effects for Hyaluronidase may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.
Side Effects of Hyaluronidase - for the Consumer
Hyaluronidase
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome when using Hyaluronidase:
Seek medical attention right away if any of these SEVERE side effects occur when using Hyaluronidase:Redness or pain at the injection site.
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); swelling at the injection site.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.
TopSide Effects by Body System - for Healthcare Professionals
Local
Local reactions are the most common side effects. The most common side effect during hypodermoclysis is edema.
Other
Hyaluronidase increases the side effects of coadministered drugs.
Hypersensitivity
Hypersensitivity reactions have included urticaria and angioedema in less than 0.1% of patients. Anaphylactic-like reactions have rarely been reported after intravenous or retrobulbar injection.
One clinic has reported a possible increase in cases of angioedema related to the use of pharmacy-compounded hyaluronidase in cataract surgery as opposed to that seen with the use of manufactured products.
Ocular
Ocular side effects have included case reports of hypersensitivity reactions after retrobulbar injections, which manifested as increased intraorbital pressure and swelling, periorbital edema, and localized pruritus.
TopMore Hyaluronidase resources
- hyaluronidase Subcutaneous, Injection Advanced Consumer (Micromedex) - Includes Dosage Information
- Hyaluronidase MedFacts Consumer Leaflet (Wolters Kluwer)
- Hyaluronidase Professional Patient Advice (Wolters Kluwer)
- Amphadase Consumer Overview
- Amphadase Prescribing Information (FDA)
- Hylenex MedFacts Consumer Leaflet (Wolters Kluwer)
- Hylenex Consumer Overview
- Vitrase Prescribing Information (FDA)
- Vitrase Consumer Overview
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