Hyaluronidase Dosage

This dosage information may not include all the information needed to use Hyaluronidase safely and effectively. See additional information for Hyaluronidase.

The information at Drugs.com is not a substitute for medical advice. ALWAYS consult your doctor or pharmacist.

Usual Adult Dose for:

Usual Pediatric Dose for:

Additional dosage information:

Usual Adult Dose for Extravasation

Stop infusion and make five 0.2 mL injections of a 15 unit/mL solution subcutaneously or intradermally around the extravasation area, using a new 25 to 26 gauge needle for each injection. Administer within 1 hour of extravasation for best results.

Other nonpharmacologic measures (i.e., aspiration of remaining drug from IV catheter, applying warm or cold compresses, elevation of affected site) appropriate for the drug should also be employed to treat the extravasation and minimize tissue exposure.

Usual Adult Dose for Hypodermoclysis

After inserting the needle, begin clysis with tip of needle lying free and movable between the skin and muscle. The fluid should start in readily without pain or lump. Then hyaluronidase should be injected into the rubber tubing close to the needle.

Alternate method: Inject hyaluronidase under skin before clysis. 150 to 200 units will facilitate absorption of 1000 mL or more of solution.

The dose, rate of injection, and type of solution should be individualized. Hypovolemia may occur if electrolyte-free solutions are given. Adding adequate quantities of electrolytes and/or controlling the volume and rate of administration will prevent hypovolemia.

Usual Adult Dose for Subcutaneous Urography

Inject 75 units over each scapula, followed by injection of the contrast medium at the same sites.

Usual Pediatric Dose for Extravasation

Stop infusion and make five 0.2 mL injections of a 15 unit/mL solution subcutaneously or intradermally around the extravasation area, using a new 25 to 26 gauge needle for each injection. Administer within 1 hour of extravasation for best results.

Some centers utilize a 150 units/mL hyaluronidase solution and, without further dilution, administer 0.2 mL injections subcutaneously or intradermally into the extravasation site at the leading edge as soon as possible (within 1 hour) after extravasation is recognized.

Other nonpharmacologic measures (i.e., aspiration of remaining drug from IV catheter, applying warm or cold compresses, elevation of affected site) appropriate for the drug and patient should also be employed to treat the extravasation and minimize tissue exposure.

Usual Pediatric Dose for Hypodermoclysis

Premature infants or neonates: The daily clysis dosage should not exceed 25 mL/kg and rate of administration should not exceed 2 mL per minute.

Less than 3 years: Volume of clysis should not exceed 200 mL.

Infants and children: 15 units are added to each 100 mL of replacement fluid to be administered or 150 units is injected under skin, followed by subcutaneous isotonic fluid administration at a rate appropriate for age, weight, and clinical condition of the patient; 150 units facilitates absorption of more than 1000 mL of solution.

The dose, rate of injection, and type of solution should be individualized. The rate and volume of clysis should be controlled to avoid overhydration. Hypovolemia may occur if electrolyte-free solutions are given. Adding adequate quantities of electrolytes and/or controlling the volume and rate of administration will prevent hypovolemia.

Usual Pediatric Dose for Subcutaneous Urography

Inject 75 units over each scapula, followed by injection of the contrast medium at the same sites.

Renal Dose Adjustments

Data not available

Liver Dose Adjustments

Data not available

Precautions

Hyaluronidase should be discontinued if sensitization occurs.

It should not be used to enhance absorption and dispersion or to treat extravasation of alpha agonists or dopamine.

Due to the risk of spreading a localized infection, hyaluronidase should not be injected into or around an acutely inflamed or infected area.

Hyaluronidase should not be used to decrease swelling due to bites or stings, be applied to the cornea, or administered intravenously.

Benzodiazepines, furosemide, and phenytoin are incompatible with hyaluronidase.

The potential for physical or chemical incompatibilities with other drugs should be kept in mind. Appropriate references should be consulted before adding hyaluronidase to other drugs.

Larger dosages of hyaluronidase may be required when large doses of salicylates, cortisone, ACTH, antihistamines, and estrogens are coadministered.

Dialysis

Data not available

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