Generic Name: dorzolamide/timolol (dor-ZOE-la-mide/TIM-oh-lol)
Brand Name: Cosopt PF
Dorzolamide/timolol drops is used for:
Treating increased pressure in the eye (ocular hypertension) and open-angle glaucoma in patients who do not respond to other medicine.
Dorzolamide/timolol drops is a carbonic anhydrase inhibitor and beta-blocker combination. It works by decreasing fluid production and pressure inside the eye.
Do NOT use dorzolamide/timolol drops if:
- you are allergic to any ingredient in dorzolamide/timolol drops
- you have severe chronic obstructive pulmonary disease (COPD) or a history of asthma
- you have moderate to severe heart block, heart failure, or an unusually slow heartbeat
- you are in shock caused by severe heart problems
- you have severe kidney problems
- you are taking an oral carbonic anhydrase inhibitor (eg, acetazolamide)
- you are using another beta-blocker eye drop (eg, betaxolol)
Contact your doctor or health care provider right away if any of these apply to you.
Before using dorzolamide/timolol drops:
Some medical conditions may interact with dorzolamide/timolol drops. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:
- if you are pregnant, planning to become pregnant, or are breast-feeding
- if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
- if you have allergies to medicines, foods, or other substances
- if you have had a severe allergic reaction (eg, severe rash, hives, difficulty breathing, dizziness) to any other sulfonamide medicine such as acetazolamide, celecoxib, certain diuretics (eg, hydrochlorothiazide), glyburide, probenecid, sulfamethoxazole, valdecoxib, or zonisamide
- if you have a history of lung or breathing problems (eg, bronchitis, COPD, emphysema), diabetes, low blood sugar, heart problems, liver or kidney problems, certain muscle problems (eg, myasthenia gravis, muscle weakness), blood vessel problems, or thyroid problems
- if you have had eye surgery, or you have an eye infection or injury, a drooping eyelid, or other eye problems (eg, narrow-angle glaucoma, double vision)
- if you will be having surgery
- if you wear contact lenses
Some MEDICINES MAY INTERACT with dorzolamide/timolol drops. Tell your health care provider if you are taking any other medicines, especially any of the following:
- Certain antiarrhythmics (eg, disopyramide, flecainide, quinidine), calcium channel blockers (eg, diltiazem, verapamil), cimetidine, digoxin, reserpine, or selective serotonin reuptake inhibitors (SSRIs) (eg, fluoxetine) because serious heart problems or low blood pressure may occur
- Clonidine because high blood pressure may occur in some cases, especially if you suddenly stop taking clonidine while taking dorzolamide/timolol drops
- Insulin or oral antidiabetics (eg, glyburide, repaglinide) because the risk of low blood sugar (eg, hunger, shakiness or weakness, dizziness, headache, sweating) or slow heart rate may be increased. Dorzolamide/timolol drops may also hide certain signs of low blood sugar
- Salicylates (eg, aspirin) because the risk of their side effects may be increased or their effectiveness may be decreased by dorzolamide/timolol drops
- Alpha-blockers (eg, alfuzosin, prazosin), oral beta-blockers (eg, propranolol), other beta-blocker eye drops (eg, betaxolol), or oral carbonic anhydrase inhibitors (eg, acetazolamide) because the risk of their side effects may be increased by dorzolamide/timolol drops
- Epinephrine, certain sympathomimetics (eg, albuterol, salmeterol), or theophylline because their effectiveness may be decreased by dorzolamide/timolol drops
This may not be a complete list of all interactions that may occur. Ask your health care provider if dorzolamide/timolol drops may interact with other medicine that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.
How to use dorzolamide/timolol drops:
Use dorzolamide/timolol drops as directed by your doctor. Check the label on the medicine for exact dosing instructions.
- An extra patient leaflet is available with dorzolamide/timolol drops. Talk to your pharmacist if you have questions about this information.
- Dorzolamide/timolol drops is only for the eye. Do not get it in your nose or mouth. Do not swallow dorzolamide/timolol drops.
- Dorzolamide/timolol drops comes in single-use containers. Use your dose immediately after you open the container. Do not store open containers for later use.
- To use dorzolamide/timolol drops in the eye, first, wash your hands. Tilt your head back. If you are unable to tilt your head, lie down. Using your index finger, pull the lower eyelid away from the eye to form a pouch. Look up and drop the medicine into the pouch. Gently close your eyes. If a drop misses your eye, try again. Do not blink. Remove excess medicine around your eye with a clean, dry tissue, being careful not to touch your eye. Wash your hands to remove any medicine that may be on them.
- There is enough medicine in one single-use container for one or both of your eyes. If your doctor has told you to use drops in both eyes, repeat these steps for your other eye.
- After you use dorzolamide/timolol drops, discard any medicine remaining in the single-use container. Do not store for later use.
- If you use other medicines in your eye, wait at least 5 minutes between using dorzolamide/timolol drops and your other eye medicines.
- Use dorzolamide/timolol drops on a regular schedule to get the most benefit from it. Using it at the same time each day will help you remember.
- Continue to use dorzolamide/timolol drops even if your condition improves. Do not miss any doses.
- If you miss a dose of dorzolamide/timolol drops, use it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not use 2 doses at once.
Ask your health care provider any questions you may have about how to use dorzolamide/timolol drops.
Important safety information:
- Dorzolamide/timolol drops may cause drowsiness, dizziness, or blurred vision. These effects may be worse if you take it with alcohol or certain medicines. Use dorzolamide/timolol drops with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
- Tell your doctor or dentist that you take dorzolamide/timolol drops before you receive any medical or dental care, emergency care, or surgery.
- Contact your doctor if you have an eye injury or infection, or if you will be having eye surgery.
- Diabetes patients - Dorzolamide/timolol drops may hide signs of low blood sugar, such as a rapid heartbeat. Be sure to watch for other signs of low blood sugar. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your vision change; give you a headache, chills, or tremors; or make you more hungry. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
- If you have a history of any severe allergic reaction, talk with your doctor. You may be at risk for an even more severe allergic reaction if you come into contact with the substance that caused your allergy. Some medicines used to treat severe allergies may also not work as well while you are using dorzolamide/timolol drops.
- Dorzolamide/timolol drops may cause harm if it is swallowed. If you may have taken it by mouth, contact your poison control center or emergency room right away.
- Lab tests, including eye exams and eye pressure, may be performed while you use dorzolamide/timolol drops. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
- Dorzolamide/timolol drops should be used with extreme caution in CHILDREN younger than 2 years old; safety and effectiveness in these children have not been confirmed.
- PREGNANCY and BREAST-FEEDING: If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using dorzolamide/timolol drops while you are pregnant. Dorzolamide/timolol drops is found in breast milk. Do not breast-feed while taking dorzolamide/timolol drops.
Possible side effects of dorzolamide/timolol drops:
All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:
Seek medical attention right away if any of these SEVERE side effects occur:
Back pain; bloodshot eyes; blurred vision; cough; dizziness; dry eyes; eyelid discomfort; feeling that something is in your eye; headache; increased tear production; minor burning, itching, or stinging of the eye; nausea; sore throat; stomach pain or upset; taste changes (eg, bitter, sour, or unusual taste).
Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, throat, or tongue; unusual hoarseness); chest, jaw, or arm pain; confusion; difficult or painful urination; eye irritation, swelling, pain, or discharge; eyelid pain, redness, scaling, drooping, or swelling; fainting; fast, slow, or irregular heartbeat; fever, chills, or persistent sore throat; mental or mood changes; one-sided weakness; pain, numbness, weakness, or tingling of an arm or leg; red, swollen, blistered, or peeling skin; severe or persistent headache or dizziness; shortness of breath; slurred speech; sudden, unexplained weight gain; sudden, unusual sweating; swelling of the hands, ankles, or feet; symptoms of liver problems (eg, dark urine, loss of appetite, pale stools, severe stomach pain, yellowing of the skin or eyes); unusual tiredness or weakness; very cold or blue fingers and toes; vision changes (eg, double vision, loss of vision); wheezing.
This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088. You may also report side effects at http://www.fda.gov/medwatch .
If OVERDOSE is suspected:
Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include chest pain; difficulty breathing or shortness of breath; severe or persistent dizziness, light-headedness, or headache; slow or irregular heartbeat.Proper storage of dorzolamide/timolol drops:
Store dorzolamide/timolol drops at room temperature, between 68 and 77 degrees F (20 and 25 degrees C). Do not freeze. Store in the original pouch. After the pouch is opened, store the remaining single-use containers in the foil pouch. Store away from heat, moisture, and light. Write down the date you open the foil pouch in the space provided on the pouch. Discard any unused containers 15 days after first opening the pouch. Keep dorzolamide/timolol drops out of the reach of children and away from pets.
- If you have any questions about dorzolamide/timolol drops, please talk with your doctor, pharmacist, or other health care provider.
- Dorzolamide/timolol drops is to be used only by the patient for whom it is prescribed. Do not share it with other people.
- If your symptoms do not improve or if they become worse, check with your doctor.
- Check with your pharmacist about how to dispose of unused medicine.
This information should not be used to decide whether or not to take dorzolamide/timolol drops or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about dorzolamide/timolol drops. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to dorzolamide/timolol drops. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using dorzolamide/timolol drops.
Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.
More about dorzolamide/timolol ophthalmic
- Dorzolamide and Timolol Ophthalmic Solution (FDA)
- Dorzolamide Hydrochloride/Timolol Maleate (Wolters Kluwer)