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Bisoprolol

Pronunciation

Generic Name: bisoprolol (BIS-oh-PROE-lol)
Brand Name: Zebeta

Bisoprolol is used for:

Treating high blood pressure. It may be used alone or with other medicines. It may also be used for other conditions as determined by your doctor.

Bisoprolol is a beta-blocker. It works by interfering with certain body chemicals, which cause the heart to beat with less force and pump out less blood. This allows the heart to beat more slowly and regularly. By blocking these chemicals, blood vessels are relaxed and widened, allowing blood pressure to decrease.

Do NOT use bisoprolol if:

  • you are allergic to any ingredient in bisoprolol
  • you are taking mibefradil or cocaine
  • you have a very slow heartbeat, heart block, very low blood pressure, or uncontrolled heart failure

Contact your doctor or health care provider right away if any of these apply to you.

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Before using bisoprolol:

Some medical conditions may interact with bisoprolol. Tell your doctor or pharmacist if you have any medical conditions, especially if any of the following apply to you:

  • if you are pregnant, planning to become pregnant, or are breast-feeding
  • if you are taking any prescription or nonprescription medicine, herbal preparation, or dietary supplement
  • if you have allergies to medicines, foods, or other substances
  • if you have or have ever had an adrenal gland tumor; severe allergic reaction; asthma; chronic bronchitis; chronic obstructive pulmonary disease, emphysema, or other lung disease; congestive heart failure; narrowing of blood vessels of the legs, arms, stomach, or kidneys; an unusually slow heartbeat; diabetes; kidney problems; or an overactive thyroid

Some MEDICINES MAY INTERACT with bisoprolol. Tell your health care provider if you are taking any other medicines, especially any of the following:

  • Bupivacaine, catecholamine-depleting agents (eg, reserpine, guanethidine), certain antiarrhythmics (eg, disopyramide, flecainide), certain calcium channel blockers (eg, diltiazem, verapamil, mibefradil), cimetidine, digoxin, ketanserin, or mefloquine because potentially life-threatening side effects on the heart may occur, including very slow heart rate, abnormal heartbeat, lightheadedness especially upon standing, difficulty breathing especially when lying down, loss of function in the heart and lungs, and swelling of ankles
  • Clonidine because excessive increases in blood pressure may occur, especially upon stopping clonidine
  • Insulin because it may make the low blood sugar last longer and the symptoms of low blood sugar, such as a rapid heartbeat, may be masked by bisoprolol

This may not be a complete list of all interactions that may occur. Ask your health care provider if bisoprolol may interact with other medicines that you take. Check with your health care provider before you start, stop, or change the dose of any medicine.

How to use bisoprolol:

Use bisoprolol as directed by your doctor. Check the label on the medicine for exact dosing instructions.

  • Take bisoprolol by mouth with or without food.
  • Taking bisoprolol at the same time each day will help you remember to take it.
  • Continue to take bisoprolol even if you feel well. Do not miss any doses.
  • If you miss a dose of bisoprolol, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not take 2 doses at once.

Ask your health care provider any questions you may have about how to use bisoprolol.

Important safety information:

  • Bisoprolol may cause drowsiness, dizziness, or lightheadedness. These effects may be worse if you take it with alcohol or certain medicines. Use bisoprolol with caution. Do not drive or perform other possibly unsafe tasks until you know how you react to it.
  • Bisoprolol may cause dizziness, lightheadedness, or fainting; alcohol, hot weather, exercise, or fever may increase these effects. To prevent them, sit up or stand slowly, especially in the morning. Sit or lie down at the first sign of any of these effects.
  • Patients who take medicine for high blood pressure often feel tired or run down for a few weeks after starting treatment. Be sure to take your medicine even if you may not feel "normal." Tell your doctor if you develop any new symptoms.
  • Diabetes patients-Bisoprolol may hide signs of low blood sugar, such as a rapid heartbeat. Be sure to watch for other signs of low blood sugar. Low blood sugar may make you anxious, sweaty, weak, dizzy, drowsy, or faint. It may also make your vision change; give you a headache, chills, or tremors; or make you more hungry. Check blood sugar levels closely. Ask your doctor before you change the dose of your diabetes medicine.
  • Tell your doctor or dentist that you take bisoprolol before you receive any medical or dental care, emergency care, or surgery.
  • Do not stop taking bisoprolol without talking to your doctor first. If you stop taking bisoprolol suddenly, you may have WITHDRAWAL symptoms. These may include chest pain, heart attack, and fast or irregular heartbeat.
  • Lab tests, including blood pressure measurements, may be performed while you use bisoprolol. These tests may be used to monitor your condition or check for side effects. Be sure to keep all doctor and lab appointments.
  • Use bisoprolol with caution in the ELDERLY; they may be more sensitive to its effects, especially mental problems.
  • Bisoprolol should not be used in CHILDREN; safety and effectiveness in children have not been confirmed.
  • PREGNANCY and BREAST-FEEDING: It is not known if bisoprolol can cause harm to the fetus. If you become pregnant, contact your doctor. You will need to discuss the benefits and risks of using bisoprolol while you are pregnant. It is not known if bisoprolol is found in breast milk. If you are or will be breast-feeding while you use bisoprolol, check with your doctor. Discuss any possible risks to your baby.

Possible side effects of bisoprolol:

All medicines may cause side effects, but many people have no, or minor, side effects. Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Diarrhea; dizziness; drowsiness; fatigue; headache; lightheadedness; nausea; sleeplessness; unusual tiredness; weakness.

Seek medical attention right away if any of these SEVERE side effects occur:

Severe allergic reactions (rash; hives; itching, difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); chest pain; difficulty breathing; lightheadedness or dizziness when rising from a lying or sitting position; very slow heartbeat.

This is not a complete list of all side effects that may occur. If you have questions about side effects, contact your health care provider. Call your doctor for medical advice about side effects. To report side effects to the appropriate agency, please read the Guide to Reporting Problems to FDA.

If OVERDOSE is suspected:

Contact 1-800-222-1222 (the American Association of Poison Control Centers), your local poison control center, or emergency room immediately. Symptoms may include difficulty breathing, especially when lying down; lightheadedness, especially upon standing; seizures (convulsions); shortness of breath; swelling of ankles; very slow heart rate; wheezing.

Proper storage of bisoprolol:

Store bisoprolol at room temperature, between 59 and 86 degrees F (15 and 30 degrees C). Store away from heat, moisture, and light. Do not store in the bathroom. Keep bisoprolol out of the reach of children and away from pets.

General information:

  • If you have any questions about bisoprolol, please talk with your doctor, pharmacist, or other health care provider.
  • Bisoprolol is to be used only by the patient for whom it is prescribed. Do not share it with other people.
  • If your symptoms do not improve or if they become worse, check with your doctor.
  • Check with your pharmacist about how to dispose of unused medicine.

This information should not be used to decide whether or not to take bisoprolol or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about bisoprolol. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to bisoprolol. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using bisoprolol.

Issue Date: September 3, 2014
Database Edition 14.3.1.003
Copyright © 2014 Wolters Kluwer Health, Inc.

Disclaimer: This information should not be used to decide whether or not to take this medicine or any other medicine. Only your health care provider has the knowledge and training to decide which medicines are right for you. This information does not endorse any medicine as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this medicine. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this medicine. This information is not specific medical advice and does not replace information you receive from your health care provider. You must talk with your healthcare provider for complete information about the risks and benefits of using this medicine.

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