Bisoprolol Dosage

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Usual Adult Dose for Hypertension

Initial dose: 5 mg orally once a day.
Maintenance dose: 5 to 20 mg orally once a day.

Usual Adult Dose for Congestive Heart Failure

Initial dose: 1.25 mg orally once a day.
Maintenance dose: This dosage may be increased by 1.25 mg after 48 hours, then weekly as needed and tolerated to a maximum recommended daily dose of 5 mg.

Usual Adult Dose for Angina Pectoris Prophylaxis

Initial dose: 5 mg orally once a day.
Maintenance dose: This dosage may be increased as needed and tolerated to prevent this patient's angina pectoris. If necessary, this dosage may be increased approximately every three days to 10 mg, then 20 mg once a day.

Usual Adult Dose for Premature Ventricular Depolarizations

Initial dose: 5 mg orally once a day.
Maintenance dose: This dosage may be increased as needed and tolerated to eradicate this patient's premature ventricular depolarizations. If necessary, this dosage may be increased approximately every three days to 10 mg, then 20 mg once a day.

Usual Adult Dose for Supraventricular Tachycardia

Initial dose: 5 mg orally once a day.
Maintenance dose: This dosage may be increased as needed and tolerated to achieve control of this patient's supraventricular tachycardia. If necessary, this dosage may be increased approximately every three days to 10 mg, then 20 mg once a day.

Renal Dose Adjustments

CrCl less than 40 mL/min: Initial dose: 2.5 mg orally once a day.
Maintenance dose: 2.5 to 20 mg orally once a day.

Liver Dose Adjustments

Initial dose: 2.5 mg orally once a day.
Maintenance dose: 2.5 to 20 mg orally once a day.

Dose Adjustments

The dose may be increased to 10 mg and then to 20 mg if needed.

Precautions

Safety and effectiveness have not been established in pediatric patients (less than 18 years of age).

Dialysis

Bisoprolol is not dialyzable by hemo- or peritoneal dialysis.

Other Comments

Compared with Caucasian patients, Black patients have a reduced blood pressure response to monotherapy with beta-blockers; however, the reduced response is largely eliminated if combination therapy that includes an adequate dose of a diuretic is instituted.

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