Generic Name: efavirenz, emtricitabine, and tenofovir (ef AV ir enz, em trye SYE ta been, and ten OF oh vir)
Brand Names: Atripla
What is Atripla?
Atripla (efavirenz, emtricitabine, and tenofovir) is an antiviral medication that prevents human immunodeficiency virus (HIV) from reproducing in your body.
Atripla treats HIV in adults and children who are at least 12 years old. HIV causes acquired immunodeficiency syndrome (AIDS). This medication is not a cure for HIV or AIDS.
Atripla may also be used for purposes not listed in this medication guide.
Important information about Atripla
Do not use Atripla if you are pregnant. It could harm the unborn baby.
There are many other drugs that can cause serious or life-threatening medical problems if you take them together with Atripla. Tell your doctor about all medications you use.
Some people develop lactic acidosis while taking Atripla. Early symptoms may get worse over time and this condition can be fatal. Get emergency medical help if you have even mild symptoms such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, fast or uneven heart rate, dizziness, or feeling very weak or tired. Atripla can cause severe or fatal liver problems. Call your doctor at once if you have symptoms such as nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes).
Before taking Atripla
You should not take Atripla if you are allergic to efavirenz (Sustiva), emtricitabine (Emtriva), or tenofovir (Viread), or if you are taking any of the following drugs:
midazolam (Versed) or triazolam (Halcion);
St. John's wort;
an ergot medicine such as dihydroergotamine (D.H.E. 45, Migranal), ergonovine (Ergotrate), ergotamine (Ergomar), or methylergonovine (Methergine);
lamivudine (Combivir, Epivir, Epzicom, or Trizivir); or
any other medicines that also contain efavirenz, emtricitabine, or tenofovir (such as Complera, Emtriva, Truvada, or Viread).
Atripla should not be used in children weighing less than 88 pounds.
To make sure you can safely take this medication, tell your doctor if you have any of these other conditions:
- liver or kidney disease;
a history of mental illness, use of antipsychotic medication, or injection drug use;
epilepsy or other seizure disorder;
osteopenia (low bone mineral density); or
hepatitis B or C infection.
Some people develop a life-threatening condition called lactic acidosis while taking Atripla. You may be more likely to develop lactic acidosis if you are overweight or have liver disease, if you are a woman, or if you have taken HIV or AIDS medications for a long time. Talk with your doctor about your individual risk.
FDA pregnancy category D. Do not use Atripla if you are pregnant. It could harm the unborn baby. Use two forms of birth control, including a barrier form (such as a condom or diaphragm with spermicide) while you are using Atripla and for at least 12 weeks after your treatment ends. HIV can be passed to your baby if you are not properly treated during pregnancy. Take all of your HIV medicines as directed to control your infection. Women with HIV or AIDS should not breast-feed a baby. Even if your baby is born without HIV, the virus may be passed to the baby in your breast milk.
See also: Atripla pregnancy and breastfeeding warnings (in more detail)
How should I take Atripla?
Take Atripla exactly as prescribed by your doctor. Do not take in larger or smaller amounts or for longer than recommended. Follow the directions on your prescription label. Use this medication regularly to get the most benefit. Get your prescription refilled before you run out of medicine completely.
Take Atripla on an empty stomach at bedtime.
To be sure this medicine is helping your condition, your blood will need to be tested often. Your liver function may also need to be tested. Visit your doctor regularly.
If you have hepatitis B you may develop liver symptoms after you stop taking Atripla, even months after stopping. Your doctor may want to check your liver function for several months after you stop using the medication.
Atripla can cause you to have a false positive drug screening test. If you provide a urine sample for drug screening, tell the laboratory staff that you are taking Atripla.
Store Atripla in the original container at room temperature, away from moisture, heat, and light. Keep the bottle tightly closed when not in use.
What happens if I miss a dose?
Take the missed dose as soon as you remember. Skip the missed dose if it is almost time for your next scheduled dose. Do not take extra medicine to make up the missed dose.
What happens if I overdose?
Seek emergency medical attention or call the Poison Help line at 1-800-222-1222. Overdose can cause uncontrolled muscle movements.
What should I avoid while taking Atripla?
Atripla may impair your thinking or reactions. Be careful if you drive or do anything that requires you to be alert. Taking this medication will not prevent you from passing HIV to other people. Do not have unprotected sex or share razors or toothbrushes. Talk with your doctor about safe ways to prevent HIV transmission during sex. Sharing drug or medicine needles is never safe, even for a healthy person.
Atripla side effects
Get emergency medical help if you have any of these signs of an allergic reaction to Atripla: hives; difficulty breathing; swelling of your face, lips, tongue, or throat. This medication may cause lactic acidosis (a build-up of lactic acid in the body, which can be fatal). Lactic acidosis can start slowly and get worse over time. Get emergency medical help if you have even mild symptoms of lactic acidosis, such as: muscle pain or weakness, numb or cold feeling in your arms and legs, trouble breathing, stomach pain, nausea with vomiting, fast or uneven heart rate, dizziness, or feeling very weak or tired.
Stop using Atripla and call your doctor at once if you have any other serious side effects such as:
signs of liver damage - nausea, upper stomach pain, itching, loss of appetite, dark urine, clay-colored stools, jaundice (yellowing of the skin or eyes);
urinating less than usual or not at all;
fever, chills, body aches, flu symptoms;
pale skin, feeling light-headed or short of breath, trouble concentrating;
rapid heart rate, increased sweating, tremors in your hands, anxiety, feeling irritable, sleep problems (insomnia);
diarrhea, unexplained weight loss, menstrual changes, impotence, loss of interest in sex;
swelling in your neck or throat (enlarged thyroid);
weakness or prickly feeling in your fingers or toes;
problems with walking, breathing, speech, swallowing, or eye movement;
severe lower back pain, loss of bladder or bowel control;
unusual thoughts or behavior, anger, severe depression, thoughts of hurting yourself or others, hallucinations;
severe blistering, peeling, and red skin rash; or
Less serious Atripla side effects may include:
mild nausea, vomiting, gas, upset stomach;
headache, dizziness, drowsiness, strange dreams;
darkened skin on the palms of your hands or the soles of your feet; or
changes in the shape or location of body fat (especially in your arms, legs, face, neck, breasts, and waist).
This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects. You may report side effects to FDA at 1-800-FDA-1088.
See also: Atripla side effects (in more detail)
What other drugs will affect Atripla?
Many drugs can interact with Atripla. Below is just a partial list. Tell your doctor if you are using:
a blood thinner such as warfarin (Coumadin, Jantoven);
an antibiotic, antiviral, or antifungal medication;
heart or blood pressure medication;
medicines used to prevent organ transplant rejection;
seizure medication; or
any other HIV medicines.
This list is not complete and there are many other drugs that can interact with Atripla. Tell your doctor about all medications you use. This includes prescription, over-the-counter, vitamin, and herbal products. Do not start a new medication without telling your doctor. Keep a list of all your medicines and show it to any healthcare provider who treats you.
More Atripla resources
Compare Atripla with other medications
Where can I get more information?
- Your pharmacist can provide more information about Atripla.
- Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use Atripla only for the indication prescribed.
- p>Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date, and complete, but no guarantee is made to that effect. Drug information contained herein may be time sensitive. Multum's drug information is an informational resource designed to assist licensed healthcare practitioners in caring for their patients and/or to serve consumers viewing this service as a supplement to, and not a substitute for, the expertise, skill, knowledge and judgment of healthcare practitioners. The absence of a warning for a given drug or drug combination in no way should be construed to indicate that the drug or drug combination is safe, effective or appropriate for any given patient. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects.
Copyright 1996-2012 Cerner Multum, Inc. Version: 8.01. Revision Date: 2012-07-12, 2:25:11 PM.