Melatonin-time-release Patient Tips

Medically reviewed by Carmen Pope, BPharm. Last updated on Aug 11, 2025.

1. How it works

• Melatonin time release is a supplement that is used to treat insomnia, sleep disorders in the blind, and decrease jet lag. It may also be effective for other health conditions.
• Melatonin is a natural hormone produced mainly by the pineal gland that our body secretes in response to darkness to help maintain our sleep-wake cycle. Environmental light inhibits the secretion of melatonin and darkness stimulates the secretion of melatonin. Secretion of melatonin in humans starts around 9 PM and peaks between 2 and 4 AM; with the duration of melatonin production varying from season to season.
• Natural melatonin is synthesized from the amino acid tryptophan and released into the blood and cerebrospinal fluid where it works by acting on receptors in the brain and other areas of the body. Most melatonin that is available as a supplement is a synthetic version of naturally occurring melatonin.
• Melatonin time release taken as a supplement, mimics the effects of naturally occurring melatonin. It may be called a hormone, a supplement, a miscellaneous hypnotic, or a nutraceutical.

2. Upsides

• Melatonin time-release is used to treat insomnia (trouble falling asleep or staying asleep), sleep disorders in the blind, and may be effective at treating jet lag, high blood pressure, anxiety, and other health conditions. Note that short-acting melatonin may be more effective at treating sleep disorders than melatonin time release.
• Melatonin time release may improve sleep duration and help people who awaken too early.
• Classified as a supplement which means it is available without a prescription from pharmacies, nutrition stores, and other retail outlets, but is not subject to the same regulations as FDA-approved medicines.
• Occasional short-term use appears safe.

3. Downsides

If you are between the ages of 18 and 60, take no other medication or have no other medical conditions, side effects you are more likely to experience include:

• Dizziness, drowsiness, bed-wetting, headache, nausea, and excessive daytime sedation are the most common side effects.
• Melatonin time release may cause drowsiness that persists and may affect a person's ability to drive or operate machinery the next day.
• Not FDA-approved which means it is not subject to the same regulations required by FDA approved medicines to adhere to.
• May not be suitable for some people including those with epilepsy or autoimmune diseases, or taking warfarin. Caffeine and fluvoxamine may elevate plasma concentrations of melatonin time release. Melatonin time release may decrease plasma concentrations of nifedipine.
• If melatonin time release is not taken at the right time of day it may cause drowsiness and delay adaption to local time.
• Some melatonin supplements use naturally occurring melatonin derived from animal pineal tissue. Their use is to be discouraged because of the risk of contamination or viral transmission.
• High doses of melatonin may affect ovulation, making it difficult for a woman to get pregnant.
• Melatonin may not work for everyone.
• Should not be given to children without medical advice.
• Dosages over 5mg appear no more effective than lower dosages and are associated with more side effects such as headache, next-day dizziness, or vivid dreams. Side effects may be worse in older adults.
• Should not be used by women who are pregnant and medical advice should be sought before using it while breastfeeding.

Note: In general, seniors or children, people with certain medical conditions (such as liver or kidney problems, heart disease, diabetes, seizures) or people who take other medications are more at risk of developing a wider range of side effects. View complete list of side effects

4. Bottom Line

Melatonin time-release is an extended-release supplement used to treat insomnia (trouble falling asleep or staying asleep), sleep disorders in the blind, and may be effective at treating jet lag, high blood pressure, anxiety, and other health conditions. Note that short-acting melatonin may be more effective at treating sleep disorders than melatonin time release. Dizziness, drowsiness, bed-wetting, headache, nausea, and excessive daytime sedation are the most common side effects reported.

5. Tips

• Use the lowest dose of melatonin time release when starting this product.
• Do not crush break or chew the extended-release tablet. Swallow whole.
• Melatonin time release may take up to an hour to be effective. Take half to one hour before going to bed at your destination (10 pm to midnight). For jet lag, one dose is usually taken each night for four nights.
• If melatonin time release appears ineffective, take short-acting melatonin. Do not take melatonin time release and short-acting melatonin together.
• Buy melatonin time release from a reputable brand with good quality control measures.
• Do not drive or operate machinery if you feel sleepy with melatonin time release the next day or within 4 hours of taking it.
• For sleep disorders, melatonin 5mg should be taken three to four hours before a defined, set, bedtime. Controlled-release melatonin may be better for maintaining sleep.
• Buy melatonin from a reputable brand with good quality control measures.
• Caffeine (contained in coffee and cola) may increase the effects of melatonin, causing increased or prolonged sedation.
• Talk to your doctor if you experience any unusual reactions after taking melatonin.
• Melatonin time release should only be used short-term unless a doctor has advised you to take it long-term.
• Do not take melatonin time release if you are pregnant and do not use it if you are breastfeeding unless on a doctor's advice.

6. Response and effectiveness

• Drowsiness may be experienced within an hour of taking melatonin time release and generally persists for several hours.
• Plasma levels of melatonin return to normal within 24 hours of a single dose of melatonin time release.

7. Interactions

Medicines that interact with melatonin time release may either decrease its effect, affect how long it works, increase side effects, or have less of an effect when taken with melatonin time release. An interaction between two medications does not always mean that you must stop taking one of the medications; however, sometimes it does. Speak to your doctor about how drug interactions should be managed.

Common medications that may interact with melatonin time release include:

• echinacea
• fluvoxamine
• hormones, such as estrogens or hydroxyprogesterone
• hydroxyprogesterone
• ifosfamide
• medications that also cause sedation, such as alprazolam, clobazam, diazepam, midazolam, temazepam, zaleplon, or zolpidem
• PARP inhibitors, such as olaparib
• some quinolone antibiotics, such as moxifloxacin
• warfarin.

Note that this list is not all-inclusive and includes only common medications that may interact with melatonin time release. You should refer to the prescribing information for melatonin time release for a complete list of interactions.

Related/similar drugs

Frequently asked questions

• What are the strongest sleeping pills?
• What is the maximum safe dosage for melatonin?
• Does Melatonin interact with any drugs?
• How to Sleep Better: Tips for Insomnia Relief
• Can you take melatonin while pregnant?
• How long does melatonin keep you asleep?
• How long does melatonin stay in your system?
• Is melatonin safe for kids to take?

Further information

Remember, keep this and all other medicines out of the reach of children, never share your medicines with others, and use melatonin-time-release only for the indication prescribed.

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Copyright 1996-2025 Drugs.com. Revision date: August 11, 2025.

Medical Disclaimer