Thrombin topical Side Effects

For the Consumer

Applies to thrombin topical: topical application powder for solution

As well as its needed effects, thrombin topical may cause unwanted side effects that require medical attention.

If any of the following side effects occur while taking thrombin topical, check with your doctor or nurse immediately:

• Difficulty breathing
• pain in the chest, groin, or legs, especially the calves
• severe, sudden headache
• slurred speech
• sudden loss of coordination
• sudden, severe weakness or numbness in the arm or leg
• sudden, unexplained shortness of breath
• vision changes

Minor Side Effects

Some thrombin topical side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:

• Burning feeling, redness, swelling, itching, or skin rash at the place of application

For Healthcare Professionals

Applies to thrombin topical: nasal powder for reconstitution, topical kit, topical pad, topical powder for reconstitution, topical solution

Hematologic

Hematologic side effects including increased activated partial thromboplastin time, increased international normalized ratio, decreased lymphocyte count, prolonged prothrombin time, and increased neutrophil count have been reported.^[Ref]

Dermatologic

Dermatologic side effects including pruritus have been reported.^[Ref]

Gastrointestinal

Gastrointestinal side effects including nausea and vomiting have been reported.

Local

Local side effects including incision site complications have been reported.^[Ref]

Immunologic

Immunologic side effects including antibody development have been reported.^[Ref]

Hypersensitivity

Hypersensitivity side effects including hypersensitivity reactions have been reported.^[Ref]

It is possible that some side effects of thrombin topical may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.

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