Thrombin topical Side Effects

For the Consumer

Applies to thrombin topical: topical application powder for solution

Along with its needed effects, thrombin topical may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking thrombin topical:

• Difficulty breathing
• pain in the chest, groin, or legs, especially the calves
• severe, sudden headache
• slurred speech
• sudden loss of coordination
• sudden, severe weakness or numbness in the arm or leg
• sudden, unexplained shortness of breath
• vision changes

Some side effects of thrombin topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

• Burning feeling, redness, swelling, itching, or skin rash at the place of application

For Healthcare Professionals

Applies to thrombin topical: nasal powder for reconstitution, topical kit, topical pad, topical powder for reconstitution, topical solution

Hematologic

Hematologic side effects including increased activated partial thromboplastin time, increased international normalized ratio, decreased lymphocyte count, prolonged prothrombin time, and increased neutrophil count have been reported.^[Ref]

Dermatologic

Dermatologic side effects including pruritus have been reported.^[Ref]

Gastrointestinal

Gastrointestinal side effects including nausea and vomiting have been reported.

Local

Local side effects including incision site complications have been reported.^[Ref]

Immunologic

Immunologic side effects including antibody development have been reported.^[Ref]

Hypersensitivity

Hypersensitivity side effects including hypersensitivity reactions have been reported.^[Ref]

Some side effects of thrombin topical may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

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