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Targretin Gel Side Effects

Generic Name: bexarotene topical

Note: This document contains side effect information about bexarotene topical. Some of the dosage forms listed on this page may not apply to the brand name Targretin Gel.

In Summary

Common side effects of Targretin Gel include: contact dermatitis, disorder of integument, pruritus, and skin rash. Other side effects include: exfoliative dermatitis, and maculopapular rash. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to bexarotene topical: topical gel/jelly

Along with its needed effects, bexarotene topical (the active ingredient contained in Targretin Gel) may cause some unwanted effects. Some side effects will have signs or symptoms that you can see or feel. Your doctor may watch for others by doing certain tests. Since the medication is applied externally to the skin, in general, these side effect are less common. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking bexarotene topical:

More common
  • Bloating or swelling of face, hands, lower legs and/or feet
  • chills, fever, or general feeling of discomfort or illness
  • decreased urination
  • lack or loss of strength
  • rapid or unusual weight gain
  • skin rash, blisters, redness, or irritation
  • sticky or tacky sensation
  • thickened, scaly skin
  • tingling or “pins and needles” sensation
  • sore throat
  • swollen, painful or tender lymph glands in neck, armpit, or groin
  • unusual bruising
  • unusual tiredness or weakness.

Some side effects of bexarotene topical may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common
  • Abnormal or excessive sweating
  • blistering, burning, crusting, dryness, flaking, itching, scaling, severe redness, soreness, or swelling of skin or lesion
  • headache
  • increased cough
  • lower back or side pain
  • painful or difficult urination

For Healthcare Professionals

Applies to bexarotene topical: topical gel


Dermatologic side effects have included rash (56% to 72%), pruritus (18% to 36%), skin disorder (18% to 26%), contact dermatitis (8% to 14%), exfoliative dermatitis (6%), maculopapular rash (6%), and sweating (6%).[Ref]


General side effects have included headache (14%), asthenia (6%), infection (18%), and pain (30%).[Ref]


Metabolic side effects have included hyperlipidemia in 10% of patients.[Ref]


Cardiovascular side effects have included edema (10%) and peripheral edema (6%).[Ref]


Hematologic side effects have included leukopenia and abnormal WBC each reported in 6% of patients.[Ref]


Lymphatic side effects have included lymphadenopathy (6%).[Ref]

Nervous system

Nervous system side effects have included paresthesia (6%).[Ref]


Respiratory side effects have included increased cough and pharyngitis in 6% of patients.[Ref]


1. Leoung GS, Aboulafla D, Millikan L, Duvic M, MacGregor RR, Gill G, Truglia J, Yocum R "Treatment of Kaposi's sarcoma using Targretin (LGD1069), a topical retinoid gel." Int Conf AIDS 11 (1996): 98(

2. "Product Information. Targretin (bexarotene topical)" Stiefel Laboratories Inc, Coral Gables, FL.

Some side effects of Targretin Gel may not be reported. Always consult your doctor or healthcare specialist for medical advice. You may also report side effects to the FDA.

Disclaimer: Every effort has been made to ensure that the information provided is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate safety, effectiveness, or appropriateness for any given patient. does not assume any responsibility for any aspect of healthcare administered with the aid of materials provided. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the substances you are taking, check with your doctor, nurse, or pharmacist.