Sirturo Side Effects
Generic Name: bedaquiline
Note: This page contains side effects data for the generic drug bedaquiline. It is possible that some of the dosage forms included below may not apply to the brand name Sirturo.
Common side effects of Sirturo include: headache and nausea. Other side effects include: hepatic insufficiency, increased liver enzymes, increased serum alanine aminotransferase, increased serum aspartate aminotransferase, increased serum transaminases, and anorexia. See below for a comprehensive list of adverse effects.
For the Consumer
Applies to bedaquiline: oral tablet
As well as its needed effects, bedaquiline (the active ingredient contained in Sirturo) may cause unwanted side effects that require medical attention.
Major Side Effects
If any of the following side effects occur while taking bedaquiline, check with your doctor immediately:More common:
- Abdominal or stomach pain or tenderness
- chest pain
- coughing or spitting up blood
- dark-colored urine
- decreased appetite
- general feeling of tiredness or weakness
- light-colored stools
- loss of appetite
- nausea and vomiting
- skin rash
- swelling of the feet or lower legs
- unusual tiredness or weakness
- yellow eyes or skin
- irregular heartbeat recurrent
Minor Side Effects
Some bedaquiline side effects may not need any medical attention. As your body gets used to the medicine these side effects may disappear. Your health care professional may be able to help you prevent or reduce these side effects, but do check with them if any of the following side effects continue, or if you are concerned about them:More common:
- Difficulty with moving
- muscle pain or stiffness
- pain in the joints
For Healthcare Professionals
Applies to bedaquiline: oral tablet
Very common (10% or more): Increased mortality risk/death (up to 12.7%), chest pain (up to 11%)[Ref]
Common (1% to 10%): QT prolongation[Ref]
Very common (10% or more): Elevated aminotransferases at least 3 times ULN (up to 10.8%)
Common (1% to 10%): Hepatotoxicity (increased ALT, increase AST, increased hepatic enzyme, abnormal hepatic function)[Ref]
Very common (10% or more): Nausea (up to 38%), vomiting (up to 20.6%)
Common (1% to 10%): Diarrhea, increased blood amylase[Ref]
Very common (10% or more): Arthralgia (up to 33%)
Common (1% to 10%): Myalgia[Ref]
Very common (10% or more): Headache (up to 28%), dizziness (up to 12.7%)[Ref]
Very common (10% or more): Hemoptysis (up to 18%)[Ref]
Common (1% to 10%): Anorexia[Ref]
Common (1% to 10%): Rash[Ref]
1. "Product Information. Sirturo (bedaquiline)." Janssen Pharmaceuticals, Titusville, NJ.
It is possible that some side effects of Sirturo may not have been reported. These can be reported to the FDA here. Always consult a healthcare professional for medical advice.
More about Sirturo (bedaquiline)
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