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Risdiplam Side Effects

Medically reviewed by Philip Thornton, DipPharm. Last updated on Feb 2, 2023.

Applies to risdiplam: oral powder for solution.

Serious side effects of Risdiplam

Along with its needed effects, risdiplam may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor immediately if any of the following side effects occur while taking risdiplam:

More common

  • Body aches or pain
  • chest pain or tightness
  • chills
  • cough
  • ear congestion
  • fever
  • headache
  • loss of voice
  • runny or stuffy nose
  • sneezing
  • sore throat
  • trouble breathing
  • unusual tiredness or weakness

Less common

  • Bladder pain
  • bloody or cloudy urine
  • difficult, burning, or painful urination
  • frequent urge to urinate
  • lower back or side pain

Other side effects of Risdiplam

Some side effects of risdiplam may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.

Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More common

Less common

  • Difficulty in moving
  • joint pain
  • muscle pain or stiffness

For Healthcare Professionals

Applies to risdiplam: oral powder for reconstitution.

General

The most reported adverse events have included fever, diarrhea, and rash; additionally, among patients with infantile-onset spinal muscular atrophy, upper respiratory tract infection, pneumonia, constipation, and vomiting were reported.[Ref]

Gastrointestinal

Very common (10% or more): Diarrhea (17%), constipation, vomiting

Common (1% to 10%): Mouth and aphthous ulcers

Other

Very common (10% or more): Fever (22%)

Dermatologic

Very common (10% or more): Rash (17%)

Rash includes reports of rash, erythema, rash maculo-papular, rash erythematous, rash popular, dermatitis allergic, and folliculitis.

Respiratory

Respiratory tract infection includes reports of nasopharyngitis, rhinitis, and respiratory tract infection.

Very common (10% or more): Upper respiratory tract infection, pneumonia

Musculoskeletal

Common (1% to 10%): Arthralgia

Genitourinary

Common (1% to 10%): Urinary tract infection

References

1. "Product Information. Evrysdi (risdiplam)." Genentech (2020):

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

Medical Disclaimer