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Lucinactant Side Effects

In Summary

Commonly reported side effects of lucinactant include: sepsis, bradycardia, hypotension, and oxygen desaturation. Other side effects include: pneumothorax. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to lucinactant: intratracheal suspension

In addition to its needed effects, some unwanted effects may be caused by lucinactant. In the event that any of these side effects do occur, they may require medical attention.

If any of the following side effects occur while taking lucinactant, check with your doctor or nurse immediately:

More common:
  • Bluish lips or skin
  • cough
  • coughing up blood
  • fast heartbeat
  • fever or chills
  • pale skin
  • rapid, shallow breathing
  • shortness of breath
  • slow heartbeat
  • sneezing
  • troubled breathing
  • wheezing
Incidence not known:
  • Blue or white in color
  • heart may stop
  • no oxygen to lungs
  • patient unresponsive

Minor Side Effects

Some of the side effects that can occur with lucinactant may not need medical attention. As your body adjusts to the medicine during treatment these side effects may go away. Your health care professional may also be able to tell you about ways to reduce or prevent some of these side effects. If any of the following side effects continue, are bothersome or if you have any questions about them, check with your health care professional:

More common:
  • clay-colored stools
  • coma
  • convulsions
  • dark urine
  • decreased urine output
  • fruit-like breath odor
  • loss of appetite
  • rapid, deep breathing
  • rash
  • restlessness
  • sweating
  • swelling of the face, ankles, or hands
  • unusual bleeding or bruising
  • vomiting of blood
  • yellow eyes or skin

For Healthcare Professionals

Applies to lucinactant: intratracheal suspension


Very common (10% or more): Patent ductus arteriosus (up to 43%), hypotension (at least 10%), bradycardia (at least 10%)
Common (1% to 10%): Pallor (up to 10%)[Ref]


Very common (10% or more): Necrotizing enterocolitis (up to 17%)[Ref]


Very common (10% or more): Anemia (at least 10%)[Ref]


Very common (10% or more): Jaundice (at least 10%)


Very common (10% or more): Metabolic acidosis (at least 10%), hyperglycemia (at least 10%), hyponatremia (at least 10%)[Ref]

Nervous system

Very common (10% or more): Intraventricular hemorrhage (up to 52%)
Common (1% to 10%): Periventricular leukomalacia (up to 10%)[Ref]


Very common (10% or more): Retinopathy of prematurity (up to 32%)[Ref]


Very common (10% or more): Acquired sepsis (up to 45%)


Very common (10% or more): Apnea (up to 66%), endotracheal tube reflux (up to 27%), endotracheal tube obstruction (up to 16%), pulmonary air leak (up to 15%), oxygen desaturation (at least 10%), pneumonia (at least 10%)
Common (1% to 10%): Pulmonary hemorrhage (up to 10%), respiratory acidosis (up to 10%), pulmonary interstitial emphysema (up to 9%), pneumothorax (up to 4%)[Ref]


1. "Product Information. Surfaxin (lucinactant)." Discovery Laboratories Inc, Warrington, PA.

Not all side effects for lucinactant may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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