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Lucinactant Side Effects

In Summary

Commonly reported side effects of lucinactant include: sepsis, bradycardia, hypotension, and oxygen desaturation. Other side effects include: pneumothorax. See below for a comprehensive list of adverse effects.

For the Consumer

Applies to lucinactant: intratracheal suspension

Along with its needed effects, lucinactant may cause some unwanted effects. Although not all of these side effects may occur, if they do occur they may need medical attention.

Check with your doctor or nurse immediately if any of the following side effects occur while taking lucinactant:

More Common

Incidence Not Known

  • Blue or white in color
  • heart may stop
  • no oxygen to lungs
  • patient unresponsive

Some side effects of lucinactant may occur that usually do not need medical attention. These side effects may go away during treatment as your body adjusts to the medicine. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about them:

More Common

  • clay-colored stools
  • coma
  • convulsions
  • dark urine
  • decreased urine output
  • fruit-like breath odor
  • loss of appetite
  • rapid, deep breathing
  • rash
  • restlessness
  • sweating
  • swelling of the face, ankles, or hands
  • unusual bleeding or bruising
  • vomiting of blood
  • yellow eyes or skin

For Healthcare Professionals

Applies to lucinactant: intratracheal suspension

Cardiovascular

Very common (10% or more): Patent ductus arteriosus (up to 43%), hypotension (at least 10%), bradycardia (at least 10%)

Common (1% to 10%): Pallor (up to 10%)[Ref]

Gastrointestinal

Very common (10% or more): Necrotizing enterocolitis (up to 17%)[Ref]

Hematologic

Very common (10% or more): Anemia (at least 10%)[Ref]

Hepatic

Very common (10% or more): Jaundice (at least 10%)

Metabolic

Very common (10% or more): Metabolic acidosis (at least 10%), hyperglycemia (at least 10%), hyponatremia (at least 10%)[Ref]

Nervous system

Very common (10% or more): Intraventricular hemorrhage (up to 52%)

Common (1% to 10%): Periventricular leukomalacia (up to 10%)[Ref]

Ocular

Very common (10% or more): Retinopathy of prematurity (up to 32%)[Ref]

Other

Very common (10% or more): Acquired sepsis (up to 45%)

Respiratory

Very common (10% or more): Apnea (up to 66%), endotracheal tube reflux (up to 27%), endotracheal tube obstruction (up to 16%), pulmonary air leak (up to 15%), oxygen desaturation (at least 10%), pneumonia (at least 10%)

Common (1% to 10%): Pulmonary hemorrhage (up to 10%), respiratory acidosis (up to 10%), pulmonary interstitial emphysema (up to 9%), pneumothorax (up to 4%)[Ref]

References

1. "Product Information. Surfaxin (lucinactant)." Discovery Laboratories Inc, Warrington, PA.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.

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