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Kovia Side Effects

Generic Name: papain / urea topical

Note: This page contains information about the side effects of papain / urea topical. Some of the dosage forms included on this document may not apply to the brand name Kovia.

For the Consumer

Applies to papain / urea topical: foam, spray, spray emulsion

Other dosage forms:

Check with your doctor if any of these most COMMON side effects persist or become bothersome:

Mild skin irritation; temporary burning sensation.

Seek medical attention right away if any of these SEVERE side effects occur while taking papain / urea topical:

Severe allergic reactions (rash; hives; itching; difficulty breathing; tightness in the chest; swelling of the mouth, face, lips, or tongue); severe or persistent skin irritation.

For Healthcare Professionals

Applies to papain / urea topical: topical foam, topical ointment, topical spray


Skin irritation is rarely caused by the exudate resulting from the enzymatic digestion. More frequent dressing changes may alleviate this discomfort until the exudate decreases.[Ref]

Local side effects have rarely included a transient burning sensation and skin irritation.[Ref]


1. "Product Information. Ethezyme (papain-urea topical)." Ethex Corporation, Saint Louis, MO.

2. "Product Information. Accuzyme (papain-urea topical)." Healthpoint, Fort Worth, TX.

Not all side effects for Kovia may be reported. You should always consult a doctor or healthcare professional for medical advice. Side effects can be reported to the FDA here.

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