Haemophilus B Conjugate (prp-t) Vaccine / Meningococcal Conjugate Vaccine Side Effects

Medically reviewed by Drugs.com. Last updated on Mar 19, 2025.

Applies to haemophilus b conjugate (prp-t) vaccine / meningococcal conjugate vaccine: intramuscular powder for injection.

Your child should not receive a booster vaccine if he or she had a life threatening allergic reaction after the first shot. Keep track of any and all side effects your child has after receiving this vaccine. When the child receives a booster dose, you will need to tell the doctor if the previous shot caused any side effects.

Becoming infected with haemophilus B or meningococcal disease is much more dangerous to your child's health than receiving this vaccine. However, like any medicine, this vaccine can cause side effects but the risk of serious side effects is extremely low.

Get emergency medical help if your child has signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Call your doctor at once if the child has a serious side effect such as:

• severe weakness, trouble breathing;

• extreme drowsiness, fainting;

• fussiness, irritability, crying for an hour or longer;

• seizure (convulsions); or

• high fever (within a few hours or a few days after the vaccine).

Common side effects may include:

• redness, pain, or swelling where the shot was given;

• low fever;

• mild fussiness or crying;

• loss of appetite; or

• drowsiness.

This is not a complete list of side effects and others may occur. Call your doctor for medical advice about side effects.

See also:

For healthcare professionals

Applies to haemophilus b conjugate (prp-t) vaccine/meningococcal conjugate vaccine: intramuscular powder for injection.

Nervous system adverse events

• Very common (10% or more): Drowsiness
• Postmarketing reports: Febrile seizures, hypotonia, headache, dizziness^[Ref]

Other

• Very common (10% or more): Fever (rectal 38C or higher)
• Uncommon (0.1% to 1%): Fever (rectal over 39.5C)
• Rare (less than 0.1%): Malaise^[Ref]

Local

• Very common (10% or more): Injection site reaction (swelling, pain, redness)
• Common (1% to 10%): Injection site reactions including induration and nodules^[Ref]

Metabolic

• Very common (10% or more): Decreased appetite^[Ref]

Psychiatric

• Very common (10% or more): Irritability
• Uncommon (0.1% to 1%): Crying
• Rare (less than 0.1%): Insomnia^[Ref]

Respiratory

• Postmarketing reports: Apnea in very premature infants (28 weeks gestation or less)^[Ref]

Gastrointestinal

• Uncommon (0.1% to 1%): Diarrhea, vomiting
• Rare (less than 0.1%): Abdominal pain^[Ref]

Dermatologic

• Uncommon (0.1% to 1%): Atopic dermatitis, rash^[Ref]

Hematologic

• Postmarketing reports: Lymphadenopathy^[Ref]

Hypersensitivity

• Postmarketing reports: Allergic reactions (including urticaria and anaphylactoid reactions)^[Ref]

Further information

Haemophilus b conjugate (prp-t) vaccine/meningococcal conjugate vaccine side effects can vary depending on the individual. Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Note: Medication side effects may be underreported. If you are experiencing side effects that are not listed, submit a report to the FDA by following this guide.

Medical Disclaimer