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Golodirsen Side Effects

Medically reviewed by Last updated on July 1, 2020.

For the Consumer

Applies to golodirsen: intravenous solution

What are some side effects that I need to call my doctor about right away?

WARNING/CAUTION: Even though it may be rare, some people may have very bad and sometimes deadly side effects when taking a drug. Tell your doctor or get medical help right away if you have any of the following signs or symptoms that may be related to a very bad side effect:

  • Signs of an allergic reaction, like rash; hives; itching; red, swollen, blistered, or peeling skin with or without fever; wheezing; tightness in the chest or throat; trouble breathing, swallowing, or talking; unusual hoarseness; or swelling of the mouth, face, lips, tongue, or throat.
  • Signs of kidney problems like unable to pass urine, change in how much urine is passed, blood in the urine, or a big weight gain.
  • Falls.
  • A fast heartbeat.
  • Ear pain.
  • Bone pain.

What are some other side effects of this drug?

All drugs may cause side effects. However, many people have no side effects or only have minor side effects. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away:

These are not all of the side effects that may occur. If you have questions about side effects, call your doctor. Call your doctor for medical advice about side effects.

You may report side effects to the FDA at 1-800-332-1088. You may also report side effects at

For Healthcare Professionals

Applies to golodirsen: intravenous solution


The most commonly reported adverse reactions have included headache, pyrexia, falls, abdominal pain, nasopharyngitis, cough, vomiting, and nausea.[Ref]


Frequency not reported: Hypersensitivity reactions

Nervous system

Very common (10% or more): Headache (41%)

Common (1% to 10%): Dizziness


Very common (10% or more): Abdominal pain (27%), vomiting (27%), nausea (20%)

Common (1% to 10%): Diarrhea, oropharyngeal pain, constipation


Common (1% to 10%): Administration site pain, catheter site related reaction


Common (1% to 10%): Influenza, seasonal allergy


Common (1% to 10%): Back pain, ligament strain, fracture


Very common (10% or more): Nasopharyngitis (27%)

Common (1% to 10%): Rhinitis


Very common (10% or more): Pyrexia (41%), fall (29%)

Common (1% to 10%): Pain, ear infection


Common (1% to 10%): Tachycardia


Common (1% to 10%): Contusion, skin abrasion


1. "Product Information. Vyondys 53 (golodirsen)." Sarepta Therapeutics, Cambridge, MA.

Frequently asked questions

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

Some side effects may not be reported. You may report them to the FDA.