Doxercalciferol Side Effects
Medically reviewed by Drugs.com. Last updated on Oct 6, 2023.
For Healthcare Professionals
Applies to doxercalciferol: intravenous solution, oral capsule.
Metabolic
Very common (10% or more): Edema (34.4%)
Common (1% to 10%): Anorexia, weight increase, dehydration
Frequency not reported: Hypercalcemia, hyperphosphatemia, hypercalciuria[Ref]
Early signs and symptoms of hypercalcemia have included weakness, headache, somnolence, nausea, vomiting, dry mouth, constipation, muscle pain, bone pain, metallic taste, and anorexia.
Prolonged hypercalcemia may result in polyuria, polydipsia, anorexia, weight loss, nocturia conjunctivitis (calcific), pancreatitis, photophobia, rhinorrhea, pruritus, hyperthermia, decreased libido, elevated blood urea nitrogen (BUN), albuminuria, hypercholesterolemia, elevated serum aspartate transaminase (AST) and alanine transaminase (ALT), ectopic calcification, hypertension, cardiac arrhythmias, sensory disturbances, dehydration, apathy, arrested growth, urinary tract infections, and, rarely, overt psychosis.
Hyperphosphatemia may exacerbate hyperparathyroidism.
Hypercalciuria may accelerate the onset of renal failure.[Ref]
Endocrine
Frequency not reported: Oversuppression of parathyroid hormone[Ref]
Oversuppression of iPTH may result in adynamic bone syndrome.[Ref]
Cardiovascular
Common (1% to 10%): Bradycardia, chest pain[Ref]
Gastrointestinal
Very common (10% or more): Nausea/vomiting (21.3%)
Common (1% to 10%): Dyspepsia, constipation[Ref]
Musculoskeletal
Common (1% to 10%): Arthralgia[Ref]
Nervous system
Very common (10% or more): Headache (27.9%), dizziness (11.5%)
Common (1% to 10%): Hypertonia, paresthesia[Ref]
Dermatologic
Common (1% to 10%): Pruritus[Ref]
Respiratory
Very common (10% or more): Dyspnea (11.5%)
Common (1% to 10%): Cough increased, rhinitis[Ref]
Other
Very common (10% or more): Malaise (27.9%)
Common (1% to 10%): Abscess[Ref]
Psychiatric
Common (1% to 10%): Sleep disorder, depression
Uncommon (0.1% to 1%): Insomnia[Ref]
Immunologic
Common (1% to 10%): Infection
Hypersensitivity
Postmarketing reports: Hypersensitivity reactions (including fatal outcome)
Hypersensitivity reactions include anaphylaxis with symptoms of angioedema (involving face, lips, tongue, and airway), hypotension, unresponsiveness, chest discomfort, shortness of breath, cardiopulmonary arrest, pruritus, and skin burning sensation. These reactions may occur separately or together.
Hematologic
Common (1% to 10%): Anemia[Ref]
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References
1. Product Information. Hectorol (doxercalciferol). Genzyme Corporation. 2001;PROD.
Further information
Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.
Some side effects may not be reported. You may report them to the FDA.