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Triprolidine Pregnancy and Breastfeeding Warnings

Triprolidine is also known as: Histex, Histex PD Drops, Histex Syrup, M-Hist PD, Tripohist, Vanaclear PD, Vanahist PD, Zymine, Zymine XR

Medically reviewed by Drugs.com. Last updated on Aug 1, 2019.

Triprolidine Pregnancy Warnings

Animal studies have not been reported. There are no controlled data in human pregnancy.

The manufacturer makes no recommendation regarding use during pregnancy.

US FDA pregnancy category: Not formally assigned to a pregnancy category.

Comments:
-Premature infants exposed to this drug near birth may be at higher risk of retrolental fibroplasia.
-Some experts recommend that patients who are pregnant should ask their healthcare provider prior to starting treatment.

See references

Triprolidine Breastfeeding Warnings

The manufacturer makes no recommendation regarding use during lactation.

Excreted into human milk: Yes

Comments:
-The American Academy of Pediatrics classifies this drug as compatible with breastfeeding.
-Some experts recommend the use of non-sedating antihistamines during lactation (e.g., desloratadine, fexofenadine, loratadine).

Use in larger doses and/or prolonged use, especially with sympathomimetics or before lactation, may result in a decreased milk supply and/or adverse effects in the breastfed infant. Antihistamines administered in relatively IV high doses to postpartum and nonlactating women have decreased basal serum prolactin; however, suckling-induced prolactin secretion was not affected by antihistamine pretreatment in postpartum patients.

See references

References for pregnancy information

  1. "Product Information. Histex PD Drops (triprolidine)." Allegis Pharmaceuticals, Canton, MS.
  2. Briggs GG, Freeman RK. "Drugs in Pregnancy and Lactation. 10th ed." Philadelphia, PA: Wolters Kluwer Health (2015):
  3. "Product Information. Histex Syrup (triprolidine)." Allegis Pharmaceuticals, Canton, MS.
  4. "Product Information. Vanaclear PD (triprolidine)." GM Pharmaceuticals, Arlington, TX.

References for breastfeeding information

  1. "Product Information. Histex Syrup (triprolidine)." Allegis Pharmaceuticals, Canton, MS.
  2. "Product Information. Histex PD Drops (triprolidine)." Allegis Pharmaceuticals, Canton, MS.
  3. Briggs GG, Freeman RK. "Drugs in Pregnancy and Lactation. 10th ed." Philadelphia, PA: Wolters Kluwer Health (2015):
  4. United States National Library of Medicine "Toxnet. Toxicology Data Network. Available from: URL: http://toxnet.nlm.nih.gov/cgi-bin/sis/htmlgen?LACT." ([cited 2013 -]):
  5. "Product Information. Vanaclear PD (triprolidine)." GM Pharmaceuticals, Arlington, TX.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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