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Thioguanine Pregnancy and Breastfeeding Warnings

Thioguanine is also known as: Tabloid

Medically reviewed on Aug 6, 2018

Thioguanine Pregnancy Warnings

Thioguanine has been assigned to pregnancy category D by the FDA. Animal studies have revealed evidence of teratogenicity. There are no controlled data in human pregnancy. Thioguanine should only be given during pregnancy when there are no alternatives and benefit outweighs risk.

Thioguanine may cause fetal harm when administered to pregnant women. Drugs such as thioguanine are potential mutagens and teratogens. If this drug is used during pregnancy, or if the patient becomes pregnant while receiving this drug, the patient should be apprised of the potential hazard to the fetus. Women of childbearing potential should be advised to avoid becoming pregnant during therapy.

In rats administered five times the human dose on the fourth and fifth days of gestation, 13% of surviving placentas did not contain fetuses and 19% of offspring were malformed or stunted. The malformations noted included generalized edema, cranial defects, and general skeletal hypoplasia, hydrocephalus, ventral hernia, situs inversus, and incomplete development of the limbs.

See references

Thioguanine Breastfeeding Warnings

There are no data on the excretion of thioguanine into human milk. Because many drugs are excreted in human milk, and because of the potential for tumorigenicity shown for thioguanine, a decision should be made whether to discontinue nursing or discontinue the drug, taking into account the importance of the drug to the mother.

See references

References for pregnancy information

  1. "Product Information. Tabloid (thioguanine)." Glaxo Wellcome, Research Triangle Park, NC.

References for breastfeeding information

  1. "Product Information. Tabloid (thioguanine)." Glaxo Wellcome, Research Triangle Park, NC.

Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.