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Somatrem Pregnancy and Breastfeeding Warnings

Somatrem is also known as: Protropin

Somatrem Pregnancy Warnings

Somatrem has been assigned to pregnancy category C by FDA. Animal studies have not been reported. There are no controlled data in human pregnancy. Somatrem is only recommended for use during pregnancy when benefit outweighs risk.

One study has suggested that human growth hormone does not cross the placenta in the direction from mother to fetus.

See references

Somatrem Breastfeeding Warnings

Recombinant human growth hormone has been studied as an agent to increase production of milk in mothers of premature infants. No adverse effects were seen in either the mothers or infants and no changes were noted in milk constituents.

There are no data on the excretion of somatrem into human milk. However, it is not expected that somatrem, a large, molecular-weight protein, would be able to pass in any significant amount into breast milk. The manufacturers recommend that caution be used when administering somatrem to nursing women.

See references

References for pregnancy information

  1. Gitlin D, Kumate J, Morales C "Metabolism and maternofetal transfer of human growth hormone in the pregnant woman at term." J Clin Endocrinol Metab 25 (1965): 1599-608
  2. "Product Information. Protropin (somatrem)." Genentech, South San Francisco, CA.

References for breastfeeding information

  1. Milsom SR, Breier BH, Gallaher BW, Cox VA, Gunn AJ, Gluckman PD "Growth hormone stimulates galactopoiesis in healthy lactating women." Acta Endocrinol (Copenh) 127 (1992): 337-43
  2. "Product Information. Protropin (somatrem)." Genentech, South San Francisco, CA.
  3. Gunn AJ, Gunn TR, Rabone DL, Breier BH, Blum WF, Gluckman PD "Growth hormone increases breast milk volumes in mothers of preterm infants." Pediatrics 98 (1996): 279-82

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