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Sodium nitrite Pregnancy and Breastfeeding Warnings

Sodium nitrite Pregnancy Warnings

Sodium nitrite has been formally assigned to pregnancy category C by the FDA. Sodium nitrite has caused fetal death in humans as well as animals. There are no controlled data in human pregnancy. Sodium nitrite is only recommended for use during pregnancy when there are no alternatives and only if the potential benefit justifies the potential risk to the fetus.

Sodium nitrite produces methemoglobin. Fetal hemoglobin is oxidized to methemoglobin more readily than adult hemoglobin. In addition, the fetus has lower levels of methemoglobin reductase than adults. Collectively, this suggests that the human fetus would show greater sensitivity to methemoglobin which could result in nitrite induced prenatal hypoxia. This hypoxia could, in turn, lead to retarded development of certain neurotransmitter systems in the brain and long lasting dysfunction.

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Sodium nitrite Breastfeeding Warnings

There are no data on the excretion of sodium nitrite into human milk. Because sodium nitrite may be administered in life-threatening situations, breast feeding is not a contraindication to its use. The manufacturer recommends that caution is used when administering sodium nitrite to nursing women.

See references

References for pregnancy information

  1. "Product Information. Sodium Nitrite (sodium nitrite)." Hope Pharmaceuticals, Scottsdale, AZ.

References for breastfeeding information

  1. "Product Information. Sodium Nitrite (sodium nitrite)." Hope Pharmaceuticals, Scottsdale, AZ.

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