Pyrazinamide Pregnancy and Breastfeeding Warnings

Medically reviewed by Drugs.com. Last updated on Jan 22, 2024.

Pyrazinamide Pregnancy Warnings

Use is not recommended unless clearly needed.

US FDA pregnancy category: C

Animal studies have not been reported. There are no controlled data in human pregnancy.

US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

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Pyrazinamide Breastfeeding Warnings

Caution is recommended; benefit to mother should outweigh risk to the infant.
-Some experts recommend: A decision should be made to discontinue breastfeeding or discontinue the drug, taking into account the importance of the drug to the mother.

Excreted into human milk: Yes

Comments:
-The WHO classifies this drug as compatible with breastfeeding; the breastfed infant should be monitored for jaundice.
-The US Centers for Disease Control and Prevention and other professional organizations state breastfeeding should not be discouraged in women taking this drug.
-Some experts recommend: Exclusively breastfed infants should be monitored for the signs/symptoms of toxicity (e.g., arthralgia, fever, hepatitis, jaundice, loss of appetite, nausea, rash, thrombocytopenia, vomiting).

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Further information

Always consult your healthcare provider to ensure the information displayed on this page applies to your personal circumstances.

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