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Pentetate calcium trisodium Pregnancy and Breastfeeding Warnings

Pentetate calcium trisodium is also known as: AN-DTPA

Pentetate calcium trisodium Pregnancy Warnings

This drug should not be used during pregnancy unless the benefit outweighs the risk to the fetus. US FDA pregnancy category: C Comments: -Chelation in pregnant women should be done with pentetate zinc trisodium, if available, unless there is high internal radiocontamination. -This drug depletes zinc, which is essential for fetal development. -Because this product is more effective than pentetate zinc trisodium in the first 24 hours after internal contamination, a single dose - with zinc containing vitamin or mineral supplements - may be appropriate.

Animal studies showed embryotoxicity and teratogenicity; gross malformations and fetal mortality increased with dose, with higher susceptibility in early and mid gestation. There are no controlled data in human pregnancy. US FDA pregnancy category C: Animal reproduction studies have shown an adverse effect on the fetus and there are no adequate and well-controlled studies in humans, but potential benefits may warrant use of the drug in pregnant women despite potential risks.

See references

Pentetate calcium trisodium Breastfeeding Warnings

Safety has not been established. Excreted into human milk: Unknown Excreted into animal milk: Data not available Comments: -Radiocontaminants are excreted in breast milk. -Women with known or suspected radioactive contamination should not breast feed. -Precautions should be taken when discarding breast milk.

See references

References for pregnancy information

  1. "Product Information. Pentetate Calcium Trisodium (pentetate calcium trisodium)." Akorn Inc, Buffalo Grove, IL.

References for breastfeeding information

  1. "Product Information. Pentetate Calcium Trisodium (pentetate calcium trisodium)." Akorn Inc, Buffalo Grove, IL.

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