Skip to Content

Metaproterenol Pregnancy and Breastfeeding Warnings

Metaproterenol is also known as: Alupent, Metaprel

Metaproterenol Pregnancy Warnings

Metaproterenol has been assigned to pregnancy category C by the FDA. Reproductive studies in mice and rabbits have demonstrated teratogenic and embryotoxic effects at doses at least 30 times the normal human oral dose. There are no controlled data in human pregnancy, although it has been used systemically to inhibit preterm labor. No fetal abnormalities have been reported with such use, however, the fetus may experience the general adverse effects reported in the mother. Use of metaproterenol in pregnant women for the relief of bronchospasm may interfere with uterine contractility. Metaproterenol is only recommended for use during pregnancy when benefit outweighs risk.

See references

Metaproterenol Breastfeeding Warnings

There are no data on the excretion of metaproterenol into human milk. The manufacturer recommends that caution be used when administering metaproterenol to nursing women.

See references

References for pregnancy information

  1. "Product Information. Alupent (metaproterenol)." Boehringer-Ingelheim, Ridgefield, CT.
  2. Baillie P, Meehan FP, Tyack AJ "Treatment of premature labour with orciprenaline." Br Med J 4 (1970): 154-5
  3. Zilianti M, Aller J "Action of orciprenaline on uterine contractility during labor, maternal cardiovascular system, fetal heart rate, and acid-base balance." Am J Obstet Gynecol 109 (1971): 1073-9

References for breastfeeding information

  1. "Product Information. Alupent (metaproterenol)." Boehringer-Ingelheim, Ridgefield, CT.

Disclaimer: Every effort has been made to ensure that the information provided by Cerner Multum, Wolters Kluwer Health and is accurate, up-to-date and complete, but no guarantee is made to that effect. In addition, the drug information contained herein may be time sensitive and should not be utilized as a reference resource beyond the date hereof. This material does not endorse drugs, diagnose patients, or recommend therapy. This drug information is a reference resource designed as supplement to, and not a substitute for, the expertise, skill , knowledge, and judgement of healthcare practitioners in patient care. The absence of a warning for a given drug or combination thereof in no way should be construed to indicate that the drug or combination is safe, effective, or appropriate for any given patient. Multum Information Services, Inc. does not assume any responsibility for any aspect of healthcare administered with the aid of information Multum provides. Copyright 2000-2008 Multum Information Services, Inc. The information contained herein is not intended to cover all possible uses, directions, precautions, warnings, drug interactions, allergic reactions, or adverse effects. If you have questions about the drugs you are taking, check with your doctor, nurse, or pharmacist.