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Guanadrel Pregnancy and Breastfeeding Warnings

Guanadrel is also known as: Hylorel

Guanadrel Pregnancy Warnings

Guanadrel has been assigned to pregnancy category B by the FDA. Animal studies have failed to reveal a statistically significant incidence of fetotoxicity or teratogenicity. Of note, however, a statistically insignificant incidence (5/80) of some congenital malformations (visceral, soft tissue, and skeletal abnormalities) and fetotoxicity were observed after doses of 30 to 100 mg/kg/day were given to rats and rabbits. There are no controlled data in human pregnancy. Guanadrel should only be given during pregnancy when benefit outweighs risk.

See references

Guanadrel Breastfeeding Warnings

There are no data on the excretion of guanadrel into human milk.

See references

References for pregnancy information

  1. Palmer JD, Nugent CA "Guanadrel sulfate: a postganglionic sympathetic inhibitor for the treatment of mild to moderate hypertension." Pharmacotherapy 3 (1983): 220-9
  2. "Product Information. Hylorel (guanadrel)." Rhone-Poulenc Rorer, Collegeville, PA.

References for breastfeeding information

  1. "Product Information. Hylorel (guanadrel)." Rhone-Poulenc Rorer, Collegeville, PA.

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