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Esterified estrogens Pregnancy and Breastfeeding Warnings

Esterified estrogens is also known as: Estratab, Menest

Esterified estrogens Pregnancy Warnings

Esterified estrogens have been assigned to pregnancy category X by the FDA. There are no controlled data in human pregnancy. Esterified estrogens are contraindicated during pregnancy.

Estrogenic agents have been associated with urogenital abnormalities in offspring that manifest later in life. Vaginal adenosis, squamous cell dysplasia of the uterine cervix, and vaginal cancer have developed later in life in female offspring. In the male offspring, the risks of urogenital abnormalities and testicular cancer later in life are increased.

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Esterified estrogens Breastfeeding Warnings

Limited data are available on the excretion of esterified estrogens into human milk. The American Academy of Pediatrics considers estradiol to be usually compatible with breast-feeding despite reports of "withdrawal" and "vaginal bleeding". Estradiol has been shown to decrease to quantity and quality of the milk. Estrogens are not indicated for the prevention of postpartum breast engorgement. The manufacturer recommends that caution be used when administering esterified estrogens to nursing women.

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References for pregnancy information

  1. Heinonen O, Slone D, Shapiro S; Kaufman DW ed. "Birth Defects and Drugs in Pregnancy." Littleton, MA: Publishing Sciences Group, Inc. (1977): 297
  2. "Product Information. Estratab (esterified estrogens)" Solvay Pharmaceuticals Inc, Marietta, GA.

References for breastfeeding information

  1. "Product Information. Estratab (esterified estrogens)" Solvay Pharmaceuticals Inc, Marietta, GA.
  2. Committee on Drugs, 1992 to 1993 "The transfer of drugs and other chemicals into human milk." Pediatrics 93 (1994): 137-50
  3. American Academy of Pediatrics Work Group on Breastfeeding. "Breastfeeding and the use of human milk." Pediatrics 100 (1997): 1035-9

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