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Botulism antitoxin Pregnancy and Breastfeeding Warnings

Botulism antitoxin Pregnancy Warnings

Botulism antitoxin type A and B has not been formally assigned to a pregnancy category by the FDA. A previously available trivalent antitoxin (types A, B, E) had been assigned to pregnancy category C. It is unknown whether the antibodies cross the placenta; however, other immunoglobulins do cross the placenta. Case reports have described administration of the antitoxin to pregnant women with no apparent short-term adverse effects.

Five vials of bivalent antitoxin were administered to a woman with severe botulism poisoning who was in her fifth month of pregnancy. She recovered and was discharged after 3 months, and had a normal delivery 1 month later.

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Botulism antitoxin Breastfeeding Warnings

There are no data on the excretion of botulism antitoxin into human milk.

See references

References for pregnancy information

  1. Polo JM, Martin J, Berciano J "Botulism and pregnancy." Lancet 348 (1996): 195
  2. "Product Information. Botulism Antitoxin Bivalent (Equine) Types A and B (botulism antitoxin bivalent (Equine) A and B)." Aventis Pharmaceuticals, Swiftwater, PA.
  3. Arnon SS, Schechter R, Inglesby TV, et al. "Botulinum toxin as a biological weapon: medical and public health management." JAMA 285 (2001): 1059-70

References for breastfeeding information

  1. "Product Information. Botulism Antitoxin Bivalent (Equine) Types A and B (botulism antitoxin bivalent (Equine) A and B)." Aventis Pharmaceuticals, Swiftwater, PA.

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