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Botulism antitoxin Pregnancy and Breastfeeding Warnings

Botulism antitoxin Pregnancy Warnings

Botulism antitoxin type A and B has not been formally assigned to a pregnancy category by the FDA. A previously available trivalent antitoxin (types A, B, E) had been assigned to pregnancy category C. It is unknown whether the antibodies cross the placenta; however, other immunoglobulins do cross the placenta. Case reports have described administration of the antitoxin to pregnant women with no apparent short-term adverse effects.

Five vials of bivalent antitoxin were administered to a woman with severe botulism poisoning who was in her fifth month of pregnancy. She recovered and was discharged after 3 months, and had a normal delivery 1 month later.

See references

Botulism antitoxin Breastfeeding Warnings

There are no data on the excretion of botulism antitoxin into human milk.

See references

References for pregnancy information

  1. Polo JM, Martin J, Berciano J "Botulism and pregnancy." Lancet 348 (1996): 195
  2. "Product Information. Botulism Antitoxin Bivalent (Equine) Types A and B (botulism antitoxin bivalent (Equine) A and B)." Aventis Pharmaceuticals, Swiftwater, PA.
  3. Arnon SS, Schechter R, Inglesby TV, et al. "Botulinum toxin as a biological weapon: medical and public health management." JAMA 285 (2001): 1059-70

References for breastfeeding information

  1. "Product Information. Botulism Antitoxin Bivalent (Equine) Types A and B (botulism antitoxin bivalent (Equine) A and B)." Aventis Pharmaceuticals, Swiftwater, PA.

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