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Methamphetamine Hydrochloride( Desoxyephedrine Hydrochloride )
Pronunciation: meth-am-FET-uh-meen HIGH-droe-KLOR-ide
- Tablets 5 mg
Activates noradrenergic neurons causing CNS and respiratory stimulation; stimulates the satiety center in the brain, causing appetite suppression.
Methamphetamine is rapidly absorbed from the GI tract.
Primary site for metabolism is the liver, by aromatic hydroxylation, N-dealkylation, and deamination. There are at least 7 metabolites.
Primary route for excretion is urine (dependent on pH) and the t ½ is 4 to 5 h.
Indications and Usage
Treatment of attention deficit disorder in children; short-term exogenous obesity adjunct.
Advanced arteriosclerosis; symptomatic CV disease; moderate to severe hypertension; hyperthyroidism; hypersensitivity to sympathomimetic amines; glaucoma; agitated states; history of drug abuse. Drug should not be used concomitantly with or within 14 days of MAOI use.
Dosage and AdministrationAttention Deficit Disorder
PO 5 mg 1 to 2 times/day; may be increased weekly by 5 mg to max of 20 to 25 mg/day in divided doses.Exogenous Obesity
Adults and Children (older than 12 yr of age)
PO 5 mg 1 to 3 times/day 30 min before meals. Not to be used beyond a few weeks.
Store in tightly closed container at room temperature (59° to 86°F).
Amphetamines may decrease effectiveness.MAOIs, furazolidone
Hypertensive crisis and intracranial hemorrhage may occur.Tricyclic Antidepressants
Decreased amphetamine effect.Urinary acidifiers
Decreased amphetamine levels.Urinary alkalinizers
Increased amphetamine levels.
Laboratory Test Interactions
Plasma and urinary steroid levels may be altered.
Palpitations; tachycardia; hypertension; arrhythmias.
Hyperactivity; dizziness; insomnia; euphoria; restlessness; tremors; headache.
Dry mouth; unpleasant taste; diarrhea; constipation; anorexia.
High abuse/diversion potential. Drug dependence may develop with chronic use. Avoid long periods of use. Prescribe and dispense sparingly because of high diversion potential.
Category C .
Excreted in breast milk.
Not recommended as anorectic agent in children less than 12 yr of age.
Some products contain tartrazine, which may cause allergic reactions in susceptible individuals.
Tolerance may occur; do not exceed recommended dose.
Restlessness, tremor, hyperreflexia, rapid respiration, confusion, assaultiveness, hallucinations, panic attack, hyperpyrexia.
- Instruct patient to take medication exactly as prescribed and not to increase dosage unless advised by health care provider.
- Advise patient to take sips of water frequently, suck on ice chips or sugarless hard candy, or chew sugarless gum if dry mouth occurs.
- Instruct patient to report excessive dryness of mouth, constipation, or prolonged insomnia as dosage may need to be adjusted.
- Tell patient to avoid caffeine, which increases drug effect.
- Advise patient that drug may cause dizziness and to use caution while driving or performing other tasks requiring mental alertness or coordination.
- Tell parents to report decreased appetite to pediatrician.
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