Class: Ophthalmic agent, direct-acting miotic
- Powder for solution, intraocular 20 mg
Decreases IOP by constricting pupil and stimulating ciliary muscles to open trabecular meshwork spaces and facilitate outflow of aqueous humor.
Special PopulationsRenal Function Impairment
No data available.Hepatic Function Impairment
No data available.
Indications and Usage
To obtain miosis of the iris in seconds after delivery of the lens in cataract surgery, in penetrating keratoplasty, iridectomy, and other anterior segment surgery where rapid miosis may be required.
Dosage and AdministrationMiosis
Intraocular Instill 0.5 to 2 mL into the anterior chamber before or after securing 1 or more sutures. In cataract surgery, use only after delivery of the lens.
- Follow manufacturer's instructions for reconstitution of powder with supplied diluent.
- Prepare solution immediately before use.
- Do not use solution that is not clear and colorless.
- Do not aspirate and inject through the same filter.
- Instillation should be gentle and parallel to the iris face and tangential to pupil border.
- Any anatomical hindrance to miosis must be released to permit the desired effect.
- Note: The syringe filter supplied has a priming volume of approximately 0.6 mL.
Store at 39° to 77°F. Discard any unused solution. Do not reuse the syringe filter and discard appropriately after use. Do not gas sterilize. If blister or peelable backing is damaged or broken, sterility of the enclosed vial and ampoule cannot be assured. Open under aseptic conditions only.
Drug InteractionsTopical NSAIDs
There have been reports that acetylcholine has been ineffective during coadministration.
Laboratory Test Interactions
None well documented.
Bradycardia, flushing, hypotension (rare).
Corneal edema, clouding, and decompensation (infrequent).
Breathing difficulties, sweating (rare).
Category C .
Safety and efficacy not established.
Cardiovascular or bronchoconstrictor responses.
- Advise patient, family, or caregiver that medication will be prepared and administered by a health care provider in a health care setting.
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