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Pelargonium

Scientific Name(s): Pelargonium graveolens, Pelargonium reniforme Curt., Pelargonium sidoides DC.
Common Name(s): African geranium, Kaloba, Kalwerbossie, Rabassamin, Umcka, Umckabo, Umckaloaba, Zucol

Medically reviewed by Drugs.com. Last updated on Dec 3, 2018.

Clinical Overview

Use

P. sidoides and P. reniforme are marketed as Umckaloaba or Zucol for bronchitis and pharyngitis. The plant species has also been investigated for use in treating gastritis. Despite a murky beginning in early 20th century herbal promotions, there appears to be some evidence for efficacy in treating bronchitis due to Pelargonium's direct antibiotic effect and host immune stimulation.

Dosing

Clinical trials have used doses of extract corresponding to 1.2 g of plant material daily without adverse reactions. Manufacturer dosage guidelines for Zucol suggest 3 lozenges every day for 6 days, even if symptoms are reduced.

Contraindications

Avoid use with hypersensitivity to any of the components in EPs 7630 or Pelargonium species. Avoid use in patients with serious kidney or liver diseases.

Pregnancy/Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking. One report recommends caution if used during pregnancy.

Interactions

None well documented.

Adverse Reactions

Clinical trials enrolling nearly 2,500 adults and children document mostly allergic reactions or GI complaints (eg, gastric pain, heartburn, nausea, diarrhea). In Germany, pharmacovigilance studies document allergic reactions associated with the use of Pelargonium extract. Case reports of fatalities linked to the use of a product containing the Pelargonium extract 1,3-dimethylamylamine (DMAA) have led to DMAA-containing products being banned by the US Department of Defense from military bases and resulted in a complete ban by the New Zealand Ministry of Health.

Toxicology

No animal toxicology studies have been reported.

Scientific Family

  • Geraniaceae

Botany

The genus Pelargonium comprises approximately 280 known species, of which 80% are grown in the interior of South Africa.1 Both of the title plant species are distinguished by the color of the flowers, the shape of the leaves, and the pollen color. P. sidoides is a small geranium-like plant that grows in a rosette from thick and very dark brown underground roots that grow up to 15 cm in length. Sparsely branched stems grow from the base and display deep red to black flowers, and the species is distinguished by the cordate or heart-shaped leaves. The pollen of the plant species is yellow. In contrast, P. reniforme has magenta red to black flowers, kidney-shaped leaves, and white to green pollen.2, 3 Both plant species may be found along the seacoast and interior portions of South Africa. Because of poor seed viability, a clonal method of propagation has been developed to reduce pressure on natural populations.4

History

The plant species indigenous to areas of South Africa are widely used by traditional healers of the Zulu, Basuto, Xhosa, and Mfengi tribes to treat dysentery, diarrhea, hepatic complaints, wounds, colds, fatigue, fevers, generalized weakness, and infections of the respiratory tract including tuberculosis.4, 5 Western use of the P. sidoides and P. reniforme species to treat tuberculosis is traced back to the Englishman Major Charles Stevens in 1897 when he was treated by a tribal healer with an extract from the roots of Pelargonium species.2

Originally, the plant source of the drug was identified as P. reniforme; however, further botanical investigations discovered the closely related species P. sidoides, which is now predominately used for therapeutic purposes.2

P. sidoides has been marketed under the brand name Umckaloaba and has been widely used in Europe since the 1980s. Economically, annual sales for the product in 2002 were $55 million or 4.1 million packages.6 The product is marketed as Zucol in the United States and is widely available. EPs 7630 is an ethanolic extract of the roots of P. sidoides, which is marketed by ISO-Arzneimittel under license from Schwabe. The DMAA extract from P. graveolens was marketed in the 1940s as an inhaled local vasoconstrictor for nasal congestion. It is an ingredient in a pre-exercise product currently marketed as Jack3d.

Chemistry

Chemical analyses have led to characterization of about 65 metabolites including phenolic and cinnamic acids, tannins, flavonoids, and coumarins in both plant species.5, 7, 8 Extracts of P. sidoides are composed of 6 main components that account for 70% to 80% of the total weight: substituted and unsubstituted oligomeric prodelphinidins, monomeric and oligomeric carbohydrates, minerals, peptides, purine derivatives, and highly substituted benzopyranones.9 Nearly 230 components have been detected in each of the plant species' essential oils, with sesquiterpenes the most abundant.10

Coumarin, 5,6-dimethoxy,7-hydroxy-coumarin, and several related ethers, glycosides, and sulfates have been isolated from both species of Pelargonium.11, 12, 13, 14 Many of these coumarins also are found in the roots of other South African Pelargonium species.12 A series of galloyl C-glycosidic flavones, along with related nongalloyl flavones, have been isolated from P. reniforme aerial parts.15P. sidoides contains similar flavonoids and phenolics.16 The high tannin content (about 9%) may justify the plant's use in GI complaints in cases of bacterial toxin-induced secretory diarrhea. The broad spectrum of activity against viruses and bacteria may be caused by the coumarins and phenolic acids.1, 2

An extract of P. graveolens, DMAA, is an aliphatic amine with sympathomimetic properties and is known by numerous other names including methylhexaneamine, 1,3-dimethylpentylamine, and Geranamine.40

Uses and Pharmacology

Numerous in vitro, animal, and clinical studies document the plant's antibacterial activity. Several fairly large clinical trials examine the plant's efficacy in treating acute bronchitis, common cold, and pharyngitis or sore throat.17

Antibacterial activity

In vitro data

The extracts of both Pelargonium species have modest direct antibacterial activity, with isolated coumarins and phenolics having minimum inhibitory concentration values from 200 to 1,000 mcg/mL in agar dilution assays versus common test bacteria.18 Unsaturated fatty acids from the roots, especially linoleic acid, had antimycobacterial activity at 2 mcg/mL in vitro.7

Immune stimulation of the host is a potential course for antimycobacterial activity. Immune stimulation by P. sidoides extracts, coumarins, and phenolics has been documented in a variety of functional assays19, 20 including enhancement of interferon-beta synthesis and activation of natural killer cell activity.21 Tannins from the plant induced nitric oxide synthase and cytokine gene expression in a macrophage-like cell line.8 The butanol root extract has antimycobacterial activity.22

Ciliary beat frequency increased in a model system after exposure to EPs 7630 extract.23 The effect was reversible and may be relevant in diverse lung and airway infections because cilia are important in removal of bacteria and foreign particulates.

Acute respiratory tract infections

Clinical data

A meta-analysis of 8 double-blind, randomized, placebo-controlled, manufacturer-funded trials (N = 746) of low to very low quality revealed effectiveness of P. sidoides (EPs 7630) alcoholic extract for relieving acute bronchitis symptoms in adults and children, and possibly sinusitis in adults as well. Very weak evidence supported effectiveness for symptom relief of acute rhinosinusitis and the common cold in adults. Formulations studied included tablets (10 to 30 mg 3 times daily X 7 days) and alcohol-extract liquid preparations (3 X 10 to 60 drops X 7 to 30 days). Adverse events were slightly higher with treatment versus placebo and none were serious (eg, GI, allergic skin reactions, urticarial).38

Bronchitis

A meta-analysis of 4 randomized clinical trials, including 1,647 patients, supported the plant's efficacy in reducing bronchitis symptoms. The mechanism of action is associated with EPs 7630 antagonism of bacterial adhesion to intact epithelia, leading to protection from bacteria colonization and infection in the upper respiratory tract.24

Clinical data

Clinical trials of EPs 7630 in acute bronchitis have been conducted in children and adults.25, 26, 27, 28, 29, 30, 31 The primary outcome or review of efficacy for most of the trials are changes in the Bronchitis Severity Score (ie, coughing, expectoration, chest pain, dyspnea, wheezing) from baseline versus the last observation (ie, final observation typically within 1 week). Inclusion criteria involved patients diagnosed with acute bronchitis within 48 hours who were not receiving antibiotic therapy, and who had no obvious contraindications to therapy. Dosage regimens included either EPs 7630 solution (30 to 90 drops per day) or tablets (10 to 30 mg per day), or placebo for 7 days. Results document the efficacy of EPs 7630 versus placebo in reducing severity of symptoms, improving quality of life, and shortening the duration of sick leave by nearly 2 days. The therapy was well tolerated, with no serious adverse reactions during the trials examined.

Chronic obstructive pulmonary disease

Clinical data

A randomized, double-blind, placebo-controlled trial enrolling 200 adults with a history of stable chronic bronchitis who experienced at least 3 exacerbations in the previous 12 months evaluated the efficacy of EPs 7630 for managing chronic obstructive pulmonary disease exacerbations. EPs 7630 (3 X 30 drops/day for 24 weeks) or placebo was added to standard inhalation therapy. Time to first exacerbation was significantly prolonged by a median of 14 days with EPs 7630 (P = 0.005), the number of moderate versus mild exacerbations was significantly lower (P < 0.0001), and fewer patients overall on the study treatment experienced exacerbations. Additionally, significantly fewer patients treated with add-on EPs 7630 required antibiotics during exacerbations compared with placebo (37.8% vs 73.3%, respectively, P < 0.0001). Health status, patient satisfaction, mean number of days off work during an exacerbation (2 vs 4 days), and total number of days off work during the 24-week study (3 vs 7 days) were all significantly better with EPs 7630 versus placebo (P < 0.01, P < 0.0001, P = 0.004, P < 0.001, respectively). More adverse events (eg, GI) were experienced in the treatment group, most of which were mild and none were serious.39

Pharyngitis

The mechanism of action may be associated with EPs 7630 antagonizing bacteria and virus adhesion to the tonsil surface or site of infection.32

Clinical data

In 2 multicenter, prospective, randomized clinical trials, EPs 7630 was more effective than placebo in the initial treatment of children (6 to 10 years of age) with acute nonstreptococcal tonsillo-pharyngitis. Patients treated with EPs 7630 had reduced severity of symptoms and shortened duration of illness by at least 2 days. The therapy also protected against complications. The treatment regimen consisted of 20 drops 3 times a day (3 mL per day), 30 minutes before or after meals for a maximum period of 6 days. No serious adverse reactions were reported.32, 33

Other pharmacological activity

Gastritis

EPs 7630 inhibited Helicobacter pylori growth and reduced bacterial adherence to gastric epithelial adrenogenital syndrome cells. EPs 7630 suppressed H. pylori growth in brain-heart infusion broth at a concentration of 100 mcg/mL and reduced H. pylori adherence at concentrations of 50 mcg/mL or more. The mechanism of action is primarily related to its antiadhesion activity.34, 35

Dosing

EPs 7630 is an 11% aqueous ethanolic extract in which 100 g of finished product corresponds to 8 g of extracted plant material. One clinical trial administered 4.5 mL 3 times daily for 7 days, corresponding to a total daily dose of plant material of approximately 1.2 g.25 A second trial used the same dosing schedule.26 Other dosage regimens used in clinical trials include the following17:

Other Dosage Regimens Used in Clinical Trials

Age

Dosage regimen

Children < 6 years of age

10 drops 3 times a day

Children 6 to 12 years of age

20 drops 3 times a day

> 12 years of age

30 drops 3 times a day

Manufacturer dosage guidelines for Zucol suggest 3 lozenges every day for 6 days, even if symptoms are reduced.

Pregnancy / Lactation

Information regarding safety and efficacy in pregnancy and lactation is lacking. One report recommends caution if used during pregnancy.36

Interactions

An interaction may be possible when patients are receiving anticoagulant medications (eg, warfarin) or antiplatelet drugs (eg, aspirin). However, a study in rats documented no pharmacokinetic or pharmacodynamic interactions between EPs 7630 and warfarin.36, 37

Adverse Reactions

Clinical trials enrolling nearly 2,500 adults and children document mostly allergic reactions or GI complaints (eg, gastric pain, heart burn, nausea, diarrhea). In Germany, pharmacovigilance studies found case reports of allergic reactions associated with the use of Pelargonium extract.36 Additional surveillance studies document similar results.28

Case studies linking the use of DMAA-containing products (ie, Jack3d) to fatal and nonfatal myocardial infarctions and cerebral hemorrhage have led to these products being banned by the New Zealand Ministry of Health and from being sold in stores on military bases by the US Department of defense. Additionally, the Medicines and Healthcare Products Regulatory Agency has extended warnings to several companies to stop selling DMAA-containing products in the UK.40

Toxicology

No reports on toxic effects of EPs 7630 are available. One investigation noted weak cytotoxic effects on coumarins in 2 human cell lines (lung carcinoma GLC4 and colorectal cancer cells COLO 320). Similar results were observed in a Salmonella reversion test. The toxic potential was classified as safe according to results from an assay on Artemia salina (brine shrimp) using extracts of EPs 7630.

References

1. Kolodziej H. Fascinating metabolic pools of Pelargonium sidoides and Pelargonium reniforme, traditional and phytomedicinal sources of the herbal medicine Umckaloabo. Phytomedicine. 2007;14(suppl 6):9-17.
2. Kolodziej H, Berlin OK. Pelargonium sidoides DC.: Latest findings towards understanding the phytotherapeutic preparation Umckaloabo. Z Phytother. 1998;19:141-151.
3. Bladt S, Wagner H. From the Zulu medicine to the European phytomedicine Umckaloabo. Phytomedicine. 2007;14(suppl 6):2-4.17239572
4. Lewu FB, Grierson DS, Afolayan AJ. Clonal propagation of Pelargonium sidoides: a threatened medicinal plant of South Africa. Afr J Biotechnol. 2006;5:123-125.
5. Kolodziej H. Traditionally used Pelargonium species: Chemistry and biological activity of umckaloabo extracts and their constituents. Curr Top Phytochem. 2000;3:77-93.
6. Patrick G, Hickner J. This obscure herb works for the common cold. J Fam Pract. 2008;57(3):157-161.18321451
7. Seidel V, Taylor PW. In vitro activity of extracts and constituents of Pelargonium against rapidly growing mycobacteria. Int J Antimicrob Agents. 2004;23(6):613-619.15194133
8. Kolodziej H, Burmeister A, Trun W, et al. Tannins and related compounds induce nitric oxide synthase and cytokines gene expressions in Leishmania major-infected macrophage-like RAW 264.7 cells. Bioorg Med Chem. 2005;13(23):6470-6476.16143535
9. Schoetz K, Erdelmeier C, Germer S, Hauer H. A detailed view on the constituents of EPs 7630. Planta Med. 2008;74(6):667-674.18449848
10. Kayser O, Latte K, Kolodziej H, Hammerschmidt F. Composition of the essential oils of Pelargonium sidoides DC and Pelargonium reniforme Curt. Flavour Fragrance J. 1998;13(3):209-212.
11. Wagner H, Bladt S. Neue cumarine aus Pelargonium reniforme Curt.-wurzel. Tetrahedron Lett. 1974;43:3807-3808.
12. Wagner H, Bladt S. Cumarine aus Südafrikanischen Pelargonium-arten. Phytochem. 1975;14:2061-2064.
13. Kayser O, Kolodziej H. Highly oxygenated coumarins from Pelargonium sidoides. Phytochemistry. 1995;39:1181-1185.
14. Kolodziej H, Kayser O, Tan N. Novel coumarin sulfates from Pelargonium sidoides: isolation, structure and synthetic approach. Proc Phytochem Soc Eur. 2002;47:59-64.11830160
15. Latté KP, Ferreira D, Venkatraman MS, Kolodziej H. O-galloyl-C-glycosylflavones from Pelargonium reniforme. Phytochemistry. 2002;59(4):419-424.11830160
16. Goedecke T, Kaloga M, Kolodziej H. A phenol glucoside, uncommon coumarins and flavonoids from Pelargonium sidoides DC. Z Naturforsch B. 2005;60:677-682.
17. Kolodziej H, Schutz V. Umchaloabo-from traditional application to modern phytodrug. Independent Pharm J Sci Prac. 2003;12:9.
18. Kayser O, Kolodziej H. Antibacterial activity of extracts and constituents of Pelargonium sidoides and Pelargonium reniforme. Planta Med. 1997;63(6):508-510.9434601
19. Kolodziej H, Kayser O, Radtke OA, Kiderlen AF, Koch E. Pharmacological profile of extracts of Pelargonium sidoides and their constituents. Phytomedicine. 2003;10(suppl 4):18-24.12807338
20. Kayser O, Kolodziej H, Kiderlen AF. Immunomodulatory principles of Pelargonium sidoides. Phytother Res. 2001;15(2):122-126.11268110
21. Koch E, Lanzendörfer-Goossens, Wohn C. Stimulation of interferon (IFN)-β-synthesis and natural killer (NK) cell activity by an aqueous-ethanolic extract from roots of Pelargonium sidoides (Umckaloabo). Naunyn-Schmiederberg's Arch Pharmacol. 2002;365(suppl 1):R75.
22. Mativanlela SP, Meyer JJ, Hussein AA, Lall N. Antitubercular activity of compounds isolated from Pelargonium sidoides. Pharm Biol. 2007;45(8):645-650.
23. Neugebauer P, Mickenhagen A, Siefer O, Walger M. A new approach to pharmacological effects on ciliary beat frequency in cell cultures—exemplary measurements under Pelargonium sidoides extract (EPs 7630). Phytomedicine. 2005;12(1-2):46-51.15693707
24. Agbabiaka TB, Guo R, Ernst E. Pelargonium sidoides for acute bronchitis: a systematic review and meta-analysis. Phytomedicine. 2008;15(5):378-385.18222667
25. Matthys H, Eisebitt R, Seith B, Heger M. Efficacy and safety of an extract of Pelargonium sidoides (EPs 7630) in adults with acute bronchitis. A randomised, double-blind, placebo-controlled trial. Phytomedicine. 2003;10(suppl 4):7-17.
26. Chuchalin AG, Berman B, Lehmacher W. Treatment of acute bronchitis in adults with a Pelargonium sidoides preparation (EPs 7630): a randomized, double-blind, placebo-controlled trial. Explore (NY). 2005;1(6):437-445.16781588
27. Haidvogl M, Graz R, Schuster M, Heger E. Acute bronchitis in childhood. Zeitschrift fur Phytotherapie. 1996;17(5):19.
28. Golovatiouk A, Chuchalin AG. Efficacy of an extract from Pelargonium sidoides (EPs 7630) compared to placebo in patients with acute bronchitis. Phytopharmaka VIII. 2002:3-12.
29. Matthys H, Heger M. EPs 7630-solution—an effective therapeutic option in acute and exacerbating bronchitis. Phytomedicine. 2007;14(suppl 6):65-68.17184984
30. Matthys H, Kamin W, Funk P, Heger M. Pelargonium sidoides preparation (EPs 7630) in the treatment of acute bronchitis in adults and children. Phytomedicine. 2007;14(suppl 6):69-73.17184981
31. Schulz V. Liquid herbal drug preparation from the root of Pelargonium sidoides is effective against acute bronchitis: results of a double-blind study with 124 patients. Phytomedicine. 2007;14(suppl 6):74-75.
32. Bereznoy VV, Riley DS, Wassmer G, Heger M. Efficacy of extract of Pelargonium sidoides in children with acute non-group A beta-hemolytic streptococcus tonsillopharyngitis: a randomized, double-blind, placebo-controlled trial. Altern Ther Health Med. 2003;9(5):68-79.14526713
33. Heger M, Bereznoy VV. Non-streptococcal tonsillo-pharyngitis in children: Efficacy of an extract from Pelargonium sidoides (EPs 7630) compared to placebo. Phytopharmaka VII Darmstadt: Steinkopff Verlag. 2002.
34. Beil W, Kilian P. EPs 7630, an extract from Pelargonium sidoides roots inhibits adherence of Helicobacter pylori to gastric epithelial cells. Phytomedicine. 2007;14(suppl 6):5-8.
35. Wittschier N, Faller G, Hensel A. An extract of Pelargonium sidoides (EPs 7630) inhibits in situ adhesion of Helicobacter pylori to human stomach. Phytomedicine. 2007;14(4):285-288.17350240
36. de Boer HJ, Hagemann U, Bate J, Meyboom RH. Allergic reactions to medicines derived from Pelargonium species. Drug Saf. 2007;30(8):677-680.17696580
37. Koch E, Biber A. Treatment of rats with the Pelargonium sidoides extract EPs 7630 has no effect on blood coagulation parameters or on the pharmacokinetics of warfarin. Phytomedicine. 2007;14(suppl 6):40-45.
38. Timmer A, Gunther J, Motschall E, Rucker G, Antes G, Kern WV. Pelargoinum sidoides extract for treating acute respiratory tract infections. Cochrane Database Syst Rev. 2013;(10):CD006323.24146345
39. Matthys H, Pliskevich DA, Bondarchuk OM, Malek FA, Tribanek M, Kieser M. Randomised, double-blind, placebo-controlled trial of EPs 7630 in adults with COPD. Respir Med. 2013;107(5):691-701.23448193
40. Smith TB, Staub BA, Natarajan GM, Lasorda DM, Poornima IG. Acute myocardial infarction associated with dietary supplements containing 1,3-dimethylamylamine and Citrus aurantium. Tex Heart Inst J. 2014;41(1):70-72.24587337

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