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Scientific Name(s): Cynara cardunculus L., Cynara scolymus L.
Common Name(s): Alcachofra, Artichaut, Extractum Cynarae aq. Siccum, Garden artichoke, Globe artichoke

Medically reviewed by Last updated on Dec 22, 2022.

Clinical Overview


Artichoke has demonstrated antioxidant, antimicrobial, and anti-inflammatory activities and has been investigated for use in the treatment of cardiovascular disease risk factors (ie, cholesterol), diabetes, GI disease, and liver diseases. However, clinical data are lacking to support use of artichoke for any indication.


In clinical trials, dosages of 600 mg/day and 2,700 mg/day of artichoke leaf extract (in divided doses) for 2 months have been studied in patients with liver diseases.


Allergy to plants in the Asteraceae family (eg, daisy, chrysanthemum, marigold, Echinacea, ragweed); bile duct obstruction; gallstones.


Artichoke heads are generally recognized as safe (GRAS) when used as food. Information regarding safety and efficacy of artichoke leaf extract in pregnancy and lactation is lacking; caution is warranted.


Colchicine: Artichoke may increase the serum concentration of colchicine. Monitor therapy.

Adverse Reactions

Mild, transient, and infrequent adverse reactions, generally limited to GI complaints such as bloating and flatulence, have been reported. Allergic reactions including anaphylaxis, bronchial asthma, and irritant contact dermatitis, as well as a case of hepatotoxicity, have been reported.


No data.

Scientific Family

  • Asteraceae (daisy)


The artichoke, a member of the daisy family, is a perennial herb widely cultivated in Mediterranean regions and in adjoining parts of central Europe. Artichoke species include the following: globe artichoke (Cynara cardunculus var. scolymus L.), cardoon (Cynara cardunculus var. altilis DC), and wild cardoon (Cynara cardunculus L. var. sylvestris). The plant grows to a height of approximately 2 m, and has a strong, erect stem with large, thistle-like leaves that are lobed and gray-green. The edible flower bud, which blooms from July to August, is purple-green and enclosed by scales or bracts. The receptacle, also known as the "heart," is edible. The plant should not be confused with the Jerusalem artichoke (Helianthus tuberosus).Ben Salem 2015, Blumenthal 2000, Chevalier 1996, Leung 2003, Sonnante 2007


Artichoke was consumed as a food and used medicinally by ancient Egyptians and Greeks; artichoke images have been discovered on ancient Egyptian tablets and altars. Artichoke was first described in the fourth century BC by the Greek writer Theophrastus. In the Roman Empire, artichoke was used as a digestive aid and enjoyed as a delicacy. Artichoke seemed to fall out of use until the 16th century, when it was used medicinally for liver ailments, such as jaundice, and also consumed by the royal and rich and considered a "noble" vegetable. The botanical name is derived in part from the tradition of fertilizing the plant with ashes, and partly from the Greek word "skolymos" (meaning "thistle") to refer to the spines on the bracts that enclose the flower heads forming the edible portion of the plant. The French have used artichoke juice as a liver tonic. Artichoke has been used traditionally to treat a variety of conditions, including hepatic diseases, jaundice, dyspepsia, and chronic albuminuria. Artichoke leaves have been used as a diuretic and as a choleretic to stimulate bile flow from the liver and gallbladder.Ben Salem 2015, Blumenthal 2000, Chevalier 1996, Leung 2003, Sonnante 2007


Nutritionally, the artichoke head contains fat, carbohydrates, and protein. It also contains fiber (inulin), calcium, phosphorus, potassium, folic acid, vitamin C, niacin, thiamine, trace minerals, and carotenoids. Artichoke is a source of essential polyunsaturated fatty acids and contains stearic, palmitic, oleic, and linoleic (50%) acids. Artichoke seed oil composition has been described. Color and anthocyanin pigments in artichoke have also been evaluated, and the identity of numerous enzymes, including oxidases, peroxidases, cynarase, and ascorbinase, have been reported.

Bitter sesquiterpene principles, such as grosheimin, cynaratriol, and cynaropicrin, have been reported, as well as dehydrocynaropicrin, grosulfeimin and related guaianolides, and cynarolide. Flavonoids (0.1% to 1%), including flavone glycosides and rutin, are present in artichoke. The flavonoid glycosides apigenin, luteolin, cynaroside, scolimoside, cosmoside, quercetin, isorhamnetin, maritimein, and others have also been reported. Volatile oils of artichoke include beta-selinene and caryophyllene as major sesquiterpenes, eugenol, phenylacetaldehyde, and decanal.

Much of the pharmacologic activity of the leaves has been attributed to the presence of polyphenolic compounds such as caffeoylquinic acid derivatives; mono- and di-caffeoylquinic acids, including chlorogenic, neochlorogenic, and cryptochlorogenic acids; luteolin; and cynarin.

Analysis by high-performance liquid chromatography and other methods has been described. The relative proportion of the various compounds varies with the strain, age, and generation of the plant. For example, germinating seeds of the artichoke have higher cynarin content than the leaves, and cynaropicrin content is highest in young leaves, while the root and mature fruits and flowers are devoid of cynaropicrin.Abu-Reidah 2013, Azzini 2007, Ben Salem 2015, Farag 2013, Hassanein 2011, Leung 2003, Nassar 2013, Negro 2012, Pandino 2011, Schauenberg 1977, Wittemer 2005

Uses and Pharmacology

Alcohol hangover

Clinical data

A randomized trial (N=15) evaluating effects of artichoke on alcoholic hangover symptoms found no difference compared with placebo.Pittler 2005

Anti-inflammatory effects

Animal data

In a murine model of inflammation, an alcohol extract of C. scolymus leaves inhibited inflammation compared with the reference group (indomethacin).Ben Salem 2017

Antimicrobial activity

In vitro data

Probiotic-enriched artichoke heads antagonized Escherichia coli and Clostridium spp. in an experiment.Valerio 2011 An extract from the fruit of artichoke inhibited Campylobacter spp. in vitro, while the leaf extracts showed antifungal activity.Zhu 2005 Pills containing 500 mg of artichoke inhibited the growth of methicillin-resistant Staphylococcus aureus, with a minimum inhibitory concentration (MIC) of 1.9 mg/mL.Pereira 2016

Antioxidant activity

Animal and in vitro data

Antioxidant activity of artichoke leaf extract has been demonstrated in animal studies using oxidative stress biomarkers.Ben Salem 2017, Jacociunas 2013, Magielse 2014 Protective effects have also been demonstrated against carbon tetrachloride–, lead-, paracetamol-, and cadmium-induced toxicity.Colak 2016, El-Boshy 2017, El Morsy 2015, Heidarian 2013

Clinical data

A small clinical study conducted in athletes found that pretreatment with artichoke leaf extract over 5 weeks increased total antioxidant capacity compared with untreated participants following intensive exercise. Effects on performance were not reported.Skarpanska-Stejnborn 2008


The components rutin, gallic acid, and quercetin from artichoke have been suggested to induce apoptosis and to decrease cancer cell proliferation.Ben Salem 2015

Animal and in vitro data

Artichoke leaf extract protected hamster ovary cells against induced DNA lesions.Jacociunas 2013 Flavonoids, polyphenol fractions, and C. cardunculus var. altilis lipophilic extracts have demonstrated chemopreventive effects in mouse skin cancers as well as human breast cancer and hepatoma cell lines.Miccadei 2008, Mileo 2012, Ramos 2016, Yasukawa 2010 In an in vitro study, an aqueous extract of C. scolymus leaves induced genotoxic effects in human hepatocellular carcinoma cells.da Silva 2017 Total and lipophilic extracts of C. cardunculus inhibited cell viability of chronic myeloid leukemia cells (ie, K562 and K562 imatinib resistant). Specifically, cynaropicrin and deacyl cynaropicrin, components of the lipophilic fraction of C. cardunculus, inhibited cell viability of these cell lines.Russo 2017 In another study, artichoke extracts (ie, Cynara syriaca and C. cardunculus) exerted inhibitory effects on the proliferation of human colorectal cancer DLD1 cells and induced the apoptosis pathway in these cells.Simsek 2013 Both in vitro and animal data suggest that a freeze-dried extract of artichoke leaf extract exerts antitumor effects on mesothelioma cell lines. Specifically, the extract caused apoptosis, decreased cell proliferation, reduced colony formation, and restrained migration and invasion of mesothelioma cells.Pulito 2015

Cardiovascular effects

Animal and in vitro data

Artichoke has demonstrated cholesterol-lowering effects in rodent studies. Leaf extracts inhibited cholesterol biosynthesis. An increased excretion of fecal bile acids was also reported. The constituents cynaroside and aglycone luteolin were suggested to be mainly responsible for this effect, while chlorogenic and caffeic dicaffeoylquinic acids and cynarin demonstrated little or no inhibitory effects.Ben Salem 2015, Küçükgergin 2010, Küskü-Kiraz 2010, Qiang 2012 Additionally, in vitro and animal data suggest potential vasodilatory activity as well as cardioprotective effects via regulation of the endothelial nitric oxide synthase gene.Ben Salem 2015 In a study of cholesterol-fed rats, C. scolymus dosed at 150, 300, or 600 mg/kg/day for 30 days reduced total cholesterol and low-density lipoprotein (LDL) cholesterol compared to a control group. The effects were similar to those noted with rats treated with simvastatin 4 mg/kg/day. Additionally, in a study evaluating the hypolipidemic and antiatherogenic effects of C. scolymus in cholesterol-fed rats, C. scolymus was associated with an improvement in biomarkers of inflammation of atherosclerosis.Mocelin 2016 In another study, an ethanolic extract of C. scolymus leaves (200 to 400 mg/kg/day) administered for 28 days reduced total cholesterol, LDL cholesterol, and triglyceride levels in alloxan-induced diabetic rats.Ben Salem 2017

In one study of rats fed an atherogenic diet, artichoke leaf extract demonstrated beneficial effects to the arterial wall by decreasing oxidative stress and triglyceride levels.Bogavac-Stanojevic 2018

In a human coronary artery smooth muscle cell line, artichoke leaf extract inhibited inducible nitric oxide synthase (iNOS) in a concentration- and time-dependent manner. The extract also decreased iNOS promotor activation and protein expression. Specifically, 4 compounds tested (ie, cynarin, cyanidin, luteolin, cynaroside) reduced iNOS mRNA expression, with cynarin being the most potent.Xia 2014

An in vitro study found C. scolymus exhibits moderate angiotensin-converting enzyme inhibitory activity.Villiger 2015

Clinical data

Two published studies have reported reductions in total cholesterol, with one demonstrating improved measures of endothelial function and the other reporting increased high-density lipoprotein (HDL) and decreased LDL. Participant numbers in these studies were small: 18 in one and 92 in the other.Lupattelli 2004, Rondanelli 2013 In a small clinical study conducted in athletes and designed to measure antioxidant effects of C. scolymus, pretreatment with artichoke leaf extract over 5 weeks decreased total cholesterol but had no effect on HDL, LDL, or triglycerides.Skarpanska-Stejnborn 2008 Similarly, in a clinical study evaluating the hypotensive effects of artichoke leaf juice in patients with mild hypertension, no effects on lipid profile, despite reductions in systolic and diastolic pressure, were observed.Roghani-Dehkordi 2009

In a systematic review of the literature, 5 studies evaluating the effects of artichoke on HDL cholesterol were evaluated. The investigators concluded that artichoke leaf extract might be a viable option for raising HDL cholesterol in patients who do not have high basal total cholesterol or HDL cholesterol levels.Rondanelli 2016

In a clinical study of 50 women with metabolic syndrome, supplementation with artichoke leaf extract 1,800 mg/day for 12 weeks reduced triglyceride levels in carriers of A allele of FTO-rs9939609 polymorphism, which is a risk factor for obesity, type 2 diabetes, and metabolic syndrome.Rezazadeh 2018

Chemotherapy-induced toxicity

Animal data

In a study of rats exposed to doxorubicin, C. scolymus and coenzyme Q10 attenuated the increases in liver and renal function parameters caused by the chemotherapeutic agent.Mustafa 2015

Dermatological effects

Animal data

Cynaropicrin extracted from artichoke leaves suppressed nuclear factor kappa B and prevented skin photoaging processes in a mouse model.Tanaka 2013

Diabetes/Glucose-lowering effects

Animal data

Limited studies in rats show a moderate hypoglycemic effect of artichoke flowering head extract.Fantini 2011, Loi 2013, Zaru 2013 An ethanolic extract of C. scolymus leaves (200 to 400 mg/kg/day) administered for 28 days reduced glucose levels in rats with alloxan-induced diabetes.Ben Salem 2017

Clinical data

In limited clinical trials in overweight subjects, reductions in glycosylated hemoglobin and glycemia have been observed with artichoke extracts alone and in combination with Phaseolus vulgaris (common bean).Rondanelli 2011, Rondanelli 2014 In a small clinical study conducted in athletes and designed to measure antioxidant effects of C. scolymus, pretreatment with artichoke leaf extract over 5 weeks had no effect on serum glucose.Skarpanska-Stejnborn 2008

Differences in clinical trial results may be influenced by genetic differences; effects of artichoke extract on insulin resistance may differ based on genetic polymorphisms.Ebrahimi-Mameghani 2018

As a component of medical nutrition therapy for patients with type 2 diabetes, the American Diabetes Association Standards of Medical Care in Diabetes (2014) guidelines recommend higher-quality dietary fat intake, as an alternative to decreased fat intake, by replacing saturated and/or trans fats with mono- and polyunsaturated fatty acids in the diet. This Mediterranean-style approach to eating may improve glycemic control and cardiovascular disease risk factors (moderate-quality evidence).ADA 2014

GI effects

Animal and in vitro data

Experiments in rodents with induced gastric ulcers have shown dose-dependent increases in mucus production and reductions in gastric ulceration with both artichoke leaf and flower bud/head extract.Costabile 2010, Ishida 2010 Guinea pig and rat ileum have demonstrated both contractile and relaxing effects from hydrophilic and lipophilic leaf extracts.Emendörfer 2005, Verspohl 2008

Clinical data

Very–long-chain inulin derived from artichoke root given to healthy adults (N=32) increased fecal bacterial count, acting as a probiotic.Riezzo 2012 Probiotic-enriched artichokes have also been used as a fiber-rich vegetable to treat constipation and deliver probiotics.Marteau 2012, Valerio 2006, Valerio 2010 Post hoc analysis of an open-label study suggests that artichoke leaf extract provides symptomatic relief in irritable bowel syndrome.Bundy 2004 A combination of ginger and artichoke leaf extract taken for 4 months was associated with improvements in measures of functional dyspepsia.Giacosa 2015 The combination was also found to promote gastric emptying in a pilot study of healthy volunteers.Lazzini 2016


Animal and in vitro data

In vitro, an artichoke leaf extract exhibited xanthine oxidase inhibitory activity; however, uric acid–lowering effects were not demonstrated following oral administration in rats.Sarawek 2008

Liver disease

Animal and in vitro data

C. scolymus leaf extract improved liver function tests in rats with liver injury from tetrachloride exposure. It also reduced lipid peroxidation by decreasing malondialdehyde levels. Additionally, superoxide dismutase and catalase activity was increased in the rats receiving C. scolymus.Colak 2016

In an in vitro study, 2 compounds (cynaropicrin and a sesquiterpene lactone termed "grosheimol") isolated from water extracts of the leaves of wild Egyptian artichoke (C. cardunculus L. var. sylvestris) inhibited all genotypes of hepatitis C virus (HCV): 1a, 1b, 3a, 4a, 5a, 6a, and 7a. Specifically, these compounds blocked HCV entry into target cells and were active against cell-free infection and cell-to-cell transmission.Elsebai 2015 In human liver samples, water extracts from the wild Egyptian artichoke inhibited CYP2B6 and 2C19 with high affinity and demonstrated moderate inhibitory activity against CYP1A2, 2D6, 2E1, and 3A4.Elsebai 2016

In a murine model of alcohol-induced liver injury, an ethanolic extract of artichoke (dose range, 0.4 to 1.6 g/kg) prevented elevations in liver function tests and cholesterol. It was also associated with reductions in degeneration, inflammatory infiltration, and hepatocyte necrosis.Tang 2017

Clinical data

In a randomized, double-blind, placebo-controlled, parallel-group study, 100 patients with nonalcoholic fatty liver disease were randomized to receive artichoke leaf extract 600 mg daily (in divided doses) or placebo for 2 months. Artichoke demonstrated beneficial effects on various ultrasound liver parameters (ie, portal vein diameter, hepatic vein flow, liver size), liver function tests, and cholesterol levels.Panahi 2018 In a similar study, C. scolymus 2,700 mg/day (in divided doses) for 2 months was found to improve liver enzymes and cholesterol levels in patients with nonalcoholic steatohepatitis.Rangboo 2016

In an open-label study of 15 patients with HCV who received a water extract of wild Egyptian artichoke (C. cardunculus L. var. sylvestris) as a tea infusion 3 times daily for 3 months, the water extract decreased HCV viral load below the detectable level and normalized liver function tests in 12 of the patients.Elsebai 2016

Renal protection

Animal data

In a murine study of gentamicin-induced nephrotoxicity, simultaneous administration of an artichoke leaf extract during gentamicin therapy exerted nephroprotective effects, as evidenced by normalization of kidney parameters (ie, serum creatinine, urea nitrogen, uric acid).Khattab 2016


In clinical trials dosages of 600 mg/day and 2,700 mg/day of artichoke leaf extract (in divided doses) for 2 months have been studied in patients with liver diseases.Panahi 2018, Rangboo 2016

Pregnancy / Lactation

Artichoke heads are GRAS when used as food. Dosages above those found in food should be avoided because safety and efficacy are unproven. Information regarding safety and efficacy of artichoke leaf extracts in pregnancy and lactation is lacking; caution is warranted.Zan 2013


Colchicine: Artichoke may increase the serum concentration of colchicine. Monitor therapy.(Campos 2018, Elsebai 2016)

Adverse Reactions

Most clinical studies with artichoke leaf extract report mild, transient, and infrequent adverse reactions generally limited to GI complaints, including bloating and flatulence.Ben Salem 2015, Costabile 2010

Contact with artichoke and other plants of the Asteraceae family (daisy, chrysanthemum, marigold, Echinacea, and ragweed) has caused allergic reactions in sensitive individuals; cynaropicrin and other sesquiterpene lactones may be the responsible chemical constituents. Case reports of pruritus, lip swelling, rhinitis, and bronchial asthma have been documented with raw artichoke.Davila Fernández 2010, Miralles 2003 Anaphylaxis due to artichoke's inulin content has been reported,Franck 2005 as well as nonallergic irritant contact dermatitis.Pipili 2009

A case report of hepatotoxicity associated with consumption of a French commercial artichoke product has been published, and the manufacturers of the product also acknowledge 2 other cases.Riezzo 2012 The Expanded Commission E Monographs warn against the use of artichoke preparations in any bile duct pathology because of artichoke's choleretic properties.Blumenthal 2000


Specific toxicological studies are limited. No toxicity was observed in in vitro studies evaluating artichoke leaf extract in hamster ovary cells.Jacociunas 2012, Jacociunas 2013 In rats, median lethal doses of 265 mg/kg (intraperitoneal) and 2,000 mg/kg (oral) have been estimated based on caffeoylquinic acid content.Leung 2003 In vitro, some genotoxicity was demonstrated on bone marrow cells at the highest dose tested (2,000 mg/kg orally), possibly due to the flavonoid content of the leaf extract.Zan 2013 Similarly, in vitro and animal data suggest that high doses of artichoke leaf extract are associated with genotoxic effects, while low doses are associated with antigenotoxic effects.Jacociunas 2013



This information relates to an herbal, vitamin, mineral or other dietary supplement. This product has not been reviewed by the FDA to determine whether it is safe or effective and is not subject to the quality standards and safety information collection standards that are applicable to most prescription drugs. This information should not be used to decide whether or not to take this product. This information does not endorse this product as safe, effective, or approved for treating any patient or health condition. This is only a brief summary of general information about this product. It does NOT include all information about the possible uses, directions, warnings, precautions, interactions, adverse effects, or risks that may apply to this product. This information is not specific medical advice and does not replace information you receive from your health care provider. You should talk with your health care provider for complete information about the risks and benefits of using this product.

This product may adversely interact with certain health and medical conditions, other prescription and over-the-counter drugs, foods, or other dietary supplements. This product may be unsafe when used before surgery or other medical procedures. It is important to fully inform your doctor about the herbal, vitamins, mineral or any other supplements you are taking before any kind of surgery or medical procedure. With the exception of certain products that are generally recognized as safe in normal quantities, including use of folic acid and prenatal vitamins during pregnancy, this product has not been sufficiently studied to determine whether it is safe to use during pregnancy or nursing or by persons younger than 2 years of age.

Abu-Reidah IM, Arráez-Román D, Segura-Carretero A, Fernández-Gutiérrez A. Extensive characterisation of bioactive phenolic constituents from globe artichoke (Cynara scolymus L.) by HPLC-DAD-ESI-QTOF-MS. Food Chem. 2013;141(3):2269-2277.23870957
American Diabetes Association. Standards of medical care in diabetes--2014. Diabetes Care. 2014;37(suppl 1):S14-S80.24357209
Azzini E, Bugianesi R, Romano F, et al. Absorption and metabolism of bioactive molecules after oral consumption of cooked edible heads of Cynara scolymus L. (cultivar Violetto di Provenza) in human subjects: a pilot study. Br J Nutr. 2007;97(5):963-969.17408528
Ben Salem M, Affes H, Athmouni K, et al. Chemical compositions, antioxidant and anti-inflammatory activity of Cynara scolymus leaves extracts, and analysis of major bioactive polyphenols by HPLC. Evid Based Complement Alternat Med. 2017;2017:4951937.28539965
Ben Salem M, Affes H, Ksouda K, et al. Pharmacological studies of artichoke leaf extract and their health benefits. Plant Foods Hum Nutr. 2015;70(4):441-453.26310198
Ben Salem M, Ben Abdallah Kolsi R, Dhouibi R, et al. Protective effects of Cynara scolymus leaves extract on metabolic disorders and oxidative stress in alloxan-diabetic rats. BMC Complement Altern Med. 2017;17(1):328.28629341
Blumenthal M, Goldberg A, Brinckmann J, eds. Herbal Medicine: Expanded Commission E Monographs. Newton, MA: Integrative Medicine Communications; 2000.
Bogavac-Stanojevic N, Kotur Stevuljevic J, Cerne D, et al. The role of artichoke leaf tincture (Cynara scolymus) in the suppression of DNA damage and atherosclerosis in rats fed an atherogenic diet. Pharm Biol. 2018;56(1):138-144.29409377
Bundy R, Walker AF, Middleton RW, Marakis G, Booth JC. Artichoke leaf extract reduces symptoms of irritable bowel syndrome and improves quality of life in otherwise healthy volunteers suffering from concomitant dyspepsia: a subset analysis. J Altern Complement Med. 2004;10(4):667-669.15353023
Campos MG, Machado J, Costa ML, Lino S, Correia F, Maltez F. Case report: severe hematological, muscle and liver toxicity caused by drugs and artichoke infusion interaction in an elderly polymedicated patient. Curr Drug Saf. 2018;13(1):44-50.28901251
Chevalier A. The Encyclopedia of Medicinal Plants. New York, NY: DK Publishing; 1996:96-97.
Colak E, Ustuner MC, Tekin N, et al. The hepatocurative effects of Cynara scolymus L. leaf extract on carbon tetrachloride-induced oxidative stress and hepatic injury in rats. Springerplus. 2016;5:216.27026910
Costabile A, Kolida S, Klinder A, et al. A double-blind, placebo-controlled, cross-over study to establish the bifidogenic effect of a very-long-chain inulin extracted from globe artichoke (Cynara scolymus) in healthy human subjects. Br J Nutr. 2010;104(7):1007-1017.20591206
da Silva RP, Jacociunas LV, de Carli RF, et al. Genotoxic and chemopreventive assessment of Cynara scolymus L. aqueous extract in a human-derived liver cell line. Drug Chem Toxicol. 2017;40(4):484-488.28147701
Davila Fernández G, Zapatero L, Bartolomé B, Fuentes V, Alonso E. Cardoon allergy. Allergol Immunopathol (Madr). 2010:38(3):165-166.20031293
Ebrahimi-Mameghani M, Asghari-Jafarabadi M, Rezazadeh K. TCF7L2-rs7903146 polymorphism modulates the effect of artichoke leaf extract supplementation on insulin resistance in metabolic syndrome: a randomized, double-blind, placebo-controlled trial. J Integr Med. 2018;16(5):329-334.30177026
El-Boshy M, Ashshi A, Gaith M, et al. Studies on the protective effect of the artichoke (Cynara scolymus) leaf extract against cadmium toxicity-induced oxidative stress, hepatorenal damage, and immunosuppressive and hematological disorders in rats. Environ Sci Pollut Res Int. 2017;24(13):12372-12383.28357802
El Morsy EM, Kamel R. Protective effect of artichoke leaf extract against paracetamol-induced hepatotoxicity in rats. Pharm Biol. 2015;53(2):167-173.25243875
Elsebai MF, Abass K, Hakkola J, Atawia AR, Farag MA. The wild Egyptian artichoke as a promising functional food for the treatment of hepatitis C virus as revealed via UPLC-MS and clinical trials. Food Funct. 2016;7(7):3006-3016.27296047
Elsebai MF, Koutsoudakis G, Saludes V, et al. Pan-genotypic hepatitis C virus inhibition by natural products derived from the wild Egyptian artichoke. J Virol. 2015;90(4):1918-1930.26656684
Emendörfer F, Emendörfer F, Bellato F, et al. Antispasmodic activity of fractions and cynaropicrin from Cynara scolymus on guinea-pig ileum. Biol Pharm Bull. 2005;28(5):902-904.15863902
Fantini N, Colombo G, Giori A, et al. Evidence of glycemia-lowering effect by a Cynara scolymus L. extract in normal and obese rats. Phytother Res. 2011;25(3):463-466.20737658
Farag MA, El-Ahmady SH, Elian FS, Wessjohann LA. Metabolomics driven analysis of artichoke leaf and its commercial products via UHPLC-q-TOF-MS and chemometrics. Phytochemistry. 2013;95:177-187.23902683
Franck P, Moneret-Vautrin DA, Morisset M, Kanny G, Mégret-Gabeaux ML, Olivier JL. Anaphylactic reaction to inulin: first identification of specific IgEs to an inulin protein compound. Int Arch Allergy Immunol. 2005;136(2):155-158.15650313
Giacosa A, Guido D, Grassi M, et al. The effect of ginger (Zingiber officinalis) and artichoke (Cynara cardunculus) extract supplementation on functional dyspepsia: A randomised, double-blind, and placebo-controlled clinical trial. Evid Based Complement Alternat Med. 2015;2015:915087.25954317
M Hassanein MM, El-Shami SM, El-Mallah MH. Investigation of lipids profiles of Nigella, lupin and artichoke seed oils to be used as healthy oils. J Oleo Sci. 2011;60(3):99-107.21343657
Heidarian E, Rafieian-Kopaei M. Protective effect of artichoke (Cynara scolymus) leaf extract against lead toxicity in rat. Pharm Biol. 2013;51(9):1104-1109.23745593
Ishida K, Kojima R, Tsuboi M, Tsuda Y, Ito M. Effects of artichoke leaf extract on acute gastric mucosal injury in rats. Biol Pharm Bull. 2010;33(2):223-229.20118544
Jacociunas LV, de Andrade HH, Lehmann M, et al. Artichoke induces genetic toxicity and decreases ethyl methanesulfonate-related DNA damage in Chinese hamster ovary cells. J Med Food. 2012;15(10):873-878.22892059
Jacociunas LV, de Andrade HH, Lehmann M, et al. Protective activity of Cynara scolymus L. leaf extract against chemically induced complex genomic alterations in CHO cells. Phytomedicine. 2013;20(12):1131-1134.23830816
Khattab HA, Wazzan MA, Al-Ahdab MA. Nephroprotective potential of artichoke leaves extract against gentamicin in rats: antioxidant mechanisms. Pak J Pharm Sci. 2016;29(5)(suppl):1775-1782.28476701
Küçükgergin C, Aydin AF, Ozdemirler-Erata G, Mehmetçik G, Koçak-Toker N, Uysal M. Effect of artichoke leaf extract on hepatic and cardiac oxidative stress in rats fed on high cholesterol diet. Biol Trace Elem Res. 2010;135(1-3):264-274.19652921
Küskü-Kiraz Z, Mehmetçik G, Dogru-Abbasoglu S, Uysal M. Artichoke leaf extract reduces oxidative stress and lipoprotein dyshomeostasis in rats fed on high cholesterol diet. Phytother Res. 2010;24(4):565-570.19777605
Lazzini S, Polinelli W, Riva A, Morazzoni P, Bombardelli E. The effect of ginger (Zingiver officinalis) and artichoke (Cynara cardunculus) extract supplementation on gastric motility: A pilot randomized study in healthy volunteers. Eur Rev Med Pharmacol Sci. 2016;20(1):146-149.26813467
Leung AY, Foster S. Encyclopedia of Common Natural Ingredients Used in Food, Drugs, and Cosmetics. 2nd ed. Hoboken, NJ: Wiley-Interscience; 2003.
Loi B, Fantini N, Colombo G, et al. Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymus extracts on food intake and glycemia in rats. Phytother Res. 2013;27(2):258-263.22565861
Lupattelli G, Marchesi S, Lombardini R, et al. Artichoke juice improves endothelial function in hyperlipemia. Life Sci. 2004;76(7):775-782.15581909
Magielse J, Verlaet A, Breynaert A, et al. Investigation of the in vivo antioxidative activity of Cynara scolymus (artichoke) leaf extract in the streptozotocin-induced diabetic rat. Mol Nutr Food Res. 2014;58(1):211-215.24254201
Marteau P. Therapy: Probiotic-enriched artichokes for abdominal discomfort. Nat Rev Gastroenterol Hepatol. 2012;9(5):251-252.22429956
Miccadei S, Di Venere D, Cardinali A, et al. Antioxidative and apoptotic properties of polyphenolic extracts from edible part of artichoke (Cynara scolymus L.) on cultured rat hepatocytes and on human hepatoma cells. Nutr Cancer. 2008;60(2):276-283.18444161
Mileo AM, Di Venere D, Linsalata V, Fraioli R, Miccadei S. Artichoke polyphenols induce apoptosis and decrease the invasive potential of the human breast cancer cell line MDA-MB231. J Cell Physiol. 2012;227(9):3301-3309.22170094
Miralles JC, García-Sells J, Bartolomé B, Negro JM. Occupational rhinitis and bronchial asthma due to artichoke (Cynara scolymus). Ann Allergy Asthma Immunol. 2003;91(1):92-95.12877457
Mocelin R, Marcon M, Santo GD, et al. Hypolipidemic and antiatherogenic effects of Cynara scolymus in cholesterol-fed rats. Rev Bras Farmacogn. 2016;26:233-239.
Mustafa HN, El Awdan SA, Hegazy GA, Abdel Jaleel GA. Prophylactic role of coenzyme Q10 and Cynara scolymus L on doxorubicin-induced toxicity in rats: biochemical and immunohistochemical study. Indian J Pharmacol. 2015;47(6):649-656.26729958
Nassar MI, Mohamed TK, Elshamy AI, El-Toumy SA, Abdel Lateef AM, Farrag AR. Chemical constituents and anti-ulcerogenic potential of the scales of Cynara scolymus (artichoke) heads. J Sci Food Agric. 2013;93(10):2494-2501.23576039
Negro D, Montesano V, Grieco S, et al. Polyphenol compounds in artichoke plant tissues and varieties. J Food Sci. 2012;77(2):C244-C252.22251096
Panahi Y, Kianpour P, Mohtashami R, et al. Efficacy of artichoke leaf extract in non-alcoholic fatty liver disease: A pilot double-blind randomized controlled trial. Phytother Res. 2018;32(7):1382-1387.29520889
Pandino G, Lombardo S, Mauromicale G. Mineral profile in globe artichoke as affected by genotype, head part and environment. J Sci Food Agric. 2011;91(2):302-308.20954162
Pereira C, Barros L, José Alves M, Santos-Buelga C, Ferreira IC. Artichoke and milk thistle pills and syrups as sources of phenolic compounds with antimicrobial activity. Food Funct. 2016;7(7):3083-3090.27273551
Pipili C, Cholongitas E, Ioannidou D. Phytocontact dermatitis caused by artichoke: an exceptionally rare case. Clin Exp Dermatol. 2009;34(4):534-535.19236426
Pittler MH, Verster JC, Ernst E. Interventions for preventing or treating alcohol hangover: systematic review of randomised controlled trials. BMJ. 2005;331(7531):1515-1518.16373736
Pulito C, Mori F, Sacconi A, et al. Cynara scolymus affects malignant pleural mesothelioma by promoting apoptosis and restraining invasion. Oncotarget. 2015;6(20):18134-18150.26136339
Qiang Z, Lee SO, Ye Z, Wu X, Hendrich S. Artichoke extract lowered plasma cholesterol and increased fecal bile acids in Golden Syrian hamsters. Phytother Res. 2012;26(7):1048-1052.22183827
Ramos PA, Guerra ÂR, Guerreiro O, et al. Antiproliferative effects of Cynara cardunculus L. var. altilis (DC) lipophilic extracts. Int J Mol Sci. 2016;18(1).28036090
Rangboo V, Noroozi M, Zavoshy R, Rezadoost SA, Mohammadpoorasl A. The effect of artichoke leaf extract on alanine aminotransferase and aspartate aminotransferase in the patients with nonalcoholic steatohepatitis. Int J Hepatol. 2016;2016:4030476.27293900
Rezazadeh K, Rahmati-Yamchi M, Mohammadnejad L, Ebrahimi-Mameghani M, Delazar A. Effects of artichoke leaf extract supplementation on metabolic parameters in women with metabolic syndrome: influence of TCF7L2-rs7903146 and FTO-rs9939609 polymorphisms. Phytother Res. 2018;32(1):84-93.29193419
Riezzo G, Orlando A, D'Attoma B, et al. Randomised clinical trial: efficacy of Lactobacillus paracasei–enriched artichokes in the treatment of patients with functional constipation—a double-blind, controlled, crossover study. Aliment Pharmacol Ther. 2012;35(4):441-450.22225544
Roghani-Dehkordi F, Kamkhah AF. Artichoke leaf juice contains antihypertensive effect in patients with mild hypertension. J Diet Suppl. 2009;6(4):328-341.22435514
Rondanelli M, Giacosa A, Morazzoni P, et al. MediterrAsian diet products that could raise HDL-cholesterol: A systematic review. Biomed Res Int. 2016;2016:2025687.27882320
Rondanelli M, Giacosa A, Opizzi A, et al. Beneficial effects of artichoke leaf extract supplementation on increasing HDL-cholesterol in subjects with primary mild hypercholesterolaemia: a double-blind, randomized, placebo-controlled trial. Int J Food Sci Nutr. 2013;64(1):7-15.22746542
Rondanelli M, Giacosa A, Orsini F, Opizzi A, Villani S. Appetite control and glycaemia reduction in overweight subjects treated with a combination of two highly standardized extracts from Phaseolus vulgaris and Cynara scolymus. Phytother Res. 2011;25(9):1275-1282.21308825
Rondanelli M, Opizzi A, Faliva M, et al. Metabolic management in overweight subjects with naive impaired fasting glycaemia by means of a highly standardized extract from Cynara scolymus: a double-blind, placebo-controlled, randomized clinical trial. Phytother Res. 2014;28(1):33-41.23440660
Russo A, Perri M, Cione E, Di Gioia ML, Nardi M, Cristina Caroleo M. Biochemical and chemical characterization of Cynara cardunculus L. extract and its potential use as co-adjuvant therapy of chronic myeloid leukemia. J Ethnopharmacol. 2017;202:184-191.28323047
Sarawek S, Feistel B, Pischel I, Butterweck V. Flavonoids of Cynara scolymus possess potent xanthinoxidase inhibitory activity in vitro but are devoid of hypouricemic effects in rats after oral application. Planta Med. 2008;74(3):221-227.18300193
Schauenberg P, Paris F. Guide to Medicinal Plants. New Canaan, CT: Keats Publishing; 1977.
Simsek EN, Uysal T. In vitro investigation of cytotoxic and apoptotic effects of Cynara L. species in colorectal cancer cells. Asian Pac J Cancer Prev. 2013;14(11):6791-6795.24377607
Skarpanska-Stejnborn A, Pilaczynska-Szczesniak L, Basta P, Deskur-Smielcka E, Horoszkiewicz-Hassan M. The influence of supplementation with artichoke (Cynara scolymus L.) extract on selected redox parameters in rowers. Int J Sport Nutr Exerc Metab. 2008;18(3):313-327.18562776
Sonnante G, Pignone D, Hammer K. The domestication of artichoke and cardoon: from Roman times to the genomic age. Ann Bot. 2007;100(5):1095-1100.17611191
Tanaka YT, Tanaka K, Kojima H, et al. Cynaropicrin from Cynara scolymus L. suppresses photoaging of skin by inhibiting the transcription activity of nuclear factor-kappa B. Bioorg Med Chem Lett. 2013;23(2):518-523.23232059
Tang X, Wei R, Deng A, Lei T. Protective effects of ethanolic extracts from artichoke, an edible herbal medicine, against acute alcohol-induced liver injury in mice. Nutrients. 2017;9(9).28891983
Valerio F, De Bellis P, Lonigro SL, Morelli L, Visconti A, Lavermicocca P. In vitro and in vivo survival and transit tolerance of potentially probiotic strains carried by artichokes in the gastrointestinal tract. Appl Environ Microbiol. 2006;72(4):3042-3045.16598015
Valerio F, de Candia S, Lonigro SL, et al. Role of the probiotic strain Lactobacillus paracasei LMGP22043 carried by artichokes in influencing faecal bacteria and biochemical parameters in human subjects. J Appl Microbiol. 2011;111(1):155-164.21447019
Valerio F, Russo F, de Candia S, et al. Effects of probiotic Lactobacillus paracasei–enriched artichokes on constipated patients: a pilot study. J Clin Gastroenterol. 2010;44(suppl 1):S49-S53.20495470
Verspohl EJ, Ploch M, Windeck T, Klaes M, Schmidt T, Bauer K. Effect of two artichoke extracts (36_U and 36_EB) on rat ileum (with respect to bowel syndrome) and the peristaltic threshold. Phytomedicine. 2008;15(11):1002-1009.18424104
Villiger A, Sala F, Suter A, Butterweck V. In vitro inhibitory potential of Cynara scolymus, Silybum marianum, Taraxacum officinale, and Peumus bolus on key enzymes relevant to metabolic syndrome. Phytomedicine. 2015;22(1):138-144.25636882
Wittemer SM, Ploch M, Windeck T, et al. Bioavailability and pharmacokinetics of caffeoylquinic acids and flavonoids after oral administration of Artichoke leaf extracts in humans. Phytomedicine. 2005;12(1-2):28-38.15693705
Xia N, Pautz A, Wollscheid U, Reifenberg G, Forstermann U, Li H. Artichoke, cynarin and cyanidin downregulate the expression of inducible nitric oxide synthase in human coronary smooth muscle cells. Molecules. 2014;19(3):3654-3668.24662080
Yasukawa K, Matsubara H, Sano Y. Inhibitory effect of the flowers of artichoke (Cynara cardunculus) on TPA-induced inflammation and tumor promotion in two-stage carcinogenesis in mouse skin. J Nat Med. 2010;64(3):388-391.20225077
Zan MA, Ferraz AB, Richter MF, et al. In vivo genotoxicity evaluation of an artichoke (Cynara scolymus L.) aqueous extract. J Food Sci. 2013;78(2):T367-T371.23330610
Zaru A, Maccioni P, Riva A, et al. Reducing effect of a combination of Phaseolus vulgaris and Cynara scolymus extracts on operant self-administration of a chocolate-flavoured beverage in rats. Phytother Res. 2013;27(6):944-947.22899449
Zhu XF, Zhang HX, Lo R. Antifungal activity of Cynara scolymus L. extracts. Fitoterapia. 2005;76(1):108-111.15664472

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