Study Quantifies Risk for Gastric, Breast Cancer for Germline CDH1 P/LP Variants
By Elana Gotkine HealthDay Reporter
FRIDAY, June 21, 2024 -- The cumulative risk for advanced gastric cancer varies from 6.5 to 10.3 percent for carriers of germline CDH1 pathogenic/likely pathogenic (P/LP) variants, according to a study published online June 14 in the Journal of the American Medical Association to coincide with presentation at the International Gastric Cancer Linkage Consortium, held from June 13 to 15 in Porto, Portugal.
Carrie E. Ryan, M.D., from the National Institutes of Health in Bethesda, Maryland, and colleagues describe gastric and breast cancer risk estimates for individuals with CDH1 variants in a multicenter retrospective cohort and modeling study. Data were included from 213 families from North America with a germline CDH1 P/LP variant; 883 of the 7,323 individuals had a CDH1 P/LP variant.
The researchers found that the prevalence of gastric cancer was 13.9 percent among those with a CDH1 P/LP variant, and the prevalence of breast cancer was 26.3 percent among female carriers. The estimated hazard ratio for advanced gastric cancer was 33.5 and 3.5 at ages 30 and 70 years, respectively. In male and female carriers, the lifetime cumulative risk for advanced gastric cancer was 10.3 and 6.5 percent, respectively. A carrier with three affected first-degree relatives had a penetrance of about 38 percent in gastric cancer risk estimates based on family history. The hazard ratio for breast cancer among female carriers was 5.7 and 3.9 at ages 30 and 70 years, respectively; the lifetime cumulative risk for breast cancer was 36.8 percent among female carriers.
"These findings inform current management of individuals with germline CDH1 variants," the authors write.
Two authors disclosed ties to the biopharmaceutical industry.
Disclaimer: Statistical data in medical articles provide general trends and do not pertain to individuals. Individual factors can vary greatly. Always seek personalized medical advice for individual healthcare decisions.
© 2025 HealthDay. All rights reserved.
Posted June 2024
Read this next
Some Triple Negative Breast Cancers Might Be Avoided by Longer Breastfeeding
THURSDAY, May 15, 2025 -- Shorter breastfeeding duration and younger age at first birth are known risk factors for triple negative breast cancer (TNBC) and vary by race, according...
Bilateral Salpingo-Oophorectomy Beneficial in BRCA1/2 Carriers With Personal History of Breast Cancer
TUESDAY, May 13, 2025 -- For carriers of pathogenic variants in BRCA1 and BRCA2 with a personal history of breast cancer, bilateral salpingo-oophorectomy (BSO) is beneficial...
Weight Gain, Late First Pregnancy Combo Increases Breast Cancer Risk
MONDAY, May 12, 2025 -- Weight gain combined with late first pregnancy (FP) or nulliparity is associated with an increased risk for breast cancer (BC), according to a study...
More news resources
- FDA Medwatch Drug Alerts
- Daily MedNews
- News for Health Professionals
- New Drug Approvals
- New Drug Applications
- Drug Shortages
- Clinical Trial Results
- Generic Drug Approvals
Subscribe to our newsletter
Whatever your topic of interest, subscribe to our newsletters to get the best of Drugs.com in your inbox.